Navigation Links
Good diets fight bad Alzheimer's genes
Date:2/15/2011

Scientists today agree that there are five molecules that are known to affect or cause Alzheimer's disease, which plagues an estimated five million Americans. The potency of these molecules is linked to environmental factors such as diet and lifestyle.

Prof. Daniel Michaelson of Tel Aviv University's Department of Neurobiology at the George S. Wise Faculty of Life Sciences has illuminating news about one of these five molecules APOE, created by the apolipoprotein E. gene found in all of our bodies.

Prof. Michaelson says APOE comes in two forms, a "good" APOE gene and a "bad" APOE gene, called APOE4. He has developed animal models to investigate the effects of diet and environment on carriers of APOE4, the presence of which is a known risk factor for Alzheimer's. It appears in 50% of all Alzheimer's patients, and in 15% of the general population which due to APOE4 is the population which is at risk of getting the disease.

The good news? In preliminary results, the researchers are exhilarated to find that a diet high in Omega 3 oils and low in cholesterol appears to significantly reduce the negative effects of the APOE4 gene in mouse models.

Exercise is not enough and may be worse

In differentiating between the good and bad variants of the APOE gene, Prof. Michaelson and his team studied many variables. They determined that while a rich and stimulating environment is good for carriers of "good" APOE, the same environment has a negative effect on those at risk for Alzheimer's because they carry the APOE4 gene. While this environment stimulated the formation of new neuronal connections in the "good APOE" mice, it caused the death of brain neurons in the "bad APOE" mice. The stimulating environment included running wheels and tubes for hiding and sliding, as well as ropes and other toys for the mice to play on, replaced and updated with new toys weekly. Those in a non-stimulating environment had access to no toys at all.

"Conditions that are generally considered good can be harmful if the mouse is a carrier of the APOE4 gene. Extrapolating this to the human population, individuals with the bad APOE4 gene are more susceptible to stress caused by an environment that stimulates their brain," says Prof. Michaelson.

Recently he expanded his original findings, first published in the Journal of Neuroscience in 2008, with a new element: diet.

APOE is a lipoprotein and known to be influenced by the good oil found in fish. Prof. Michaelson and his European colleagues, under a joint European Commission grant called LIPIDIDIET, constructed an experiment. In a standardized environment, they introduced three different kinds of diet: a normal diet, a "bad" diet high in cholesterol, and a "good" diet high in fish oil.

When it's good, it's good

"The main take-away message here is that good diets can alleviate the effects of bad genes. Of course nutritionists have had this general idea for a while, but it's nice to be able to show that this approach can be applied to specifically counteract the negative effects of Alzheimer's disease-related genes," says Prof. Michaelson.

The results with more details will be presented at an international conference in Barcelona, Spain this March.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related biology news :

1. Mothers diets have biggest influence on children eating healthy
2. Personalized diets for elderly after hospitalization decreases mortality rates
3. New sleep cycle discovery explains why fatty diets during pregnancy make kids obese
4. Why fad diets work well for some, but not others
5. TV food advertisements promote imbalanced diets
6. Studies on nutrients, gene expression could lead to tailored diets for disease prevention
7. New study shows teens who drink 100 percent fruit juice have more nutritious diets overall
8. Happy holidays from the groaning board; Western diets turn on fat genes
9. Do high-fat diets make us stupid and lazy?
10. ADA releases updated position paper on vegetarian diets
11. People of higher socioeconomic status choose better diets -- but pay more per calorie
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Good diets fight bad Alzheimer's genes
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... 2017 /PRNewswire/ -  GeneNews Limited (TSX:GEN) ("GeneNews" or the ... new risk stratification test for breast cancer, via its ... ("IDL"). BreastSentry incorporates a blood-based biomarker test with a sophisticated ... developing breast cancer.   ... BreastSentry measures the fasting plasma levels of ...
(Date:3/28/2017)... ... March 28, 2017 , ... NetDimensions announced ... processes and enhance training plan management for consistent implementation of standards and regulatory ... the SHL Group to help improve and streamline their training and employee development ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... II Small Business Innovation Research (SBIR) grant from the National Science Foundation (NSF). ... two years to develop a suite of BioGelâ„¢ biopolymer materials for hygiene applications, ...
(Date:3/28/2017)... 28, 2017 Volition America, Inc., a wholly-owned U.S. ... engagement of Deborah Vollmer Dahlke , DrPH, CEO and ... Vollmer Dahlke,s role will be to assist the ... State of Texas and elsewhere in ... has significant experience over the past six years, helping ...
Breaking Biology Technology: