Navigation Links
Good bacteria armed with antibiotic resistance protect gut microbiome
Date:6/12/2014

Researchers from Case Western Reserve University in Cleveland have discovered that populating the gastrointestinal (GI) tracts of mice with Bacteroides species producing a specific enzyme helps protect the good commensal bacteria from the harmful effects of antibiotics. Their research is published ahead of print in Antimicrobial Agents and Chemotherapy.

Antibiotics are powerful weapons against pathogens, but most are relatively indiscriminate, killing the good bacteria, along with the bad. Thus, they may render patients vulnerable to invasion, particularly by virulent, antibiotic-resistant pathogens that frequently populate hospitals.

The novel aspect of the research is that the enzyme produced by these bacteria, beta-lactamase, is a major cause of antibiotic resistance, says first author, Usha Stiefel. Interestingly, the enzyme is not only protecting the bacteria that produce it but also the rest of the bacteria making up the intestinal microbiome.

In the study, the investigators established populations of beta-lactamase producing Bacteroides in some mice, but not others. They then gave all the mice ceftriaxone, a beta-lactam antibiotic, for three days and then oral doses of vancomycin-resistant enterococcus, or Clostridium difficile, both of which are virulent GI pathogens.

The mice that had been populated with Bacteroides maintained their diverse species of commensal gut bacteria, free of pathogens, while the control mice saw their commensals decimated by antibiotics, enabling establishment of the pathogens.

"When patients in the hospital or nursing home setting receive antibiotics, it is doubly dangerous when they lose their native colonic bacteria, because healthcare settings are full of resistant or particularly virulent bacteria, and so patients are especially vulnerable to acquiring these bacteria within their intestinal tracts," says Stiefel.

Since the Bact
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... Md. , April 2, 2015 At ... Salt Lake City , the American College ... of five new directors to its Board.  Members of ... the ACMG and for forming and advancing its policies ... medical genetics profession. "It,s an eventful time ...
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... not affect how long you will live. Instead it is how ... reveals research from the University of Gothenburg recently published in the ... that people with parents who lived to be very old are ... that,s just not true our study shows that hereditary factors ...
... be a problem of towns and cities but new research published ... shows that binge drinking in rural areas is more of ... Psychiatric University Clinic Erlangen, looked at the drinking patterns of over ... more than 93% of the young people from the countryside and ...
... Kyoto, Japan -- In a complex feat of ... the University of Oxford have succeeded in creating a ... be observed in real time. The results, appearing in ... the door to the development of advanced drug delivery ...
Cached Biology News:Lifestyle affects life expectancy more than genetics 2
(Date:4/20/2015)... , April 20, 2015 PointCross Life ... Ltd. to provide an integrated Big Data and globally ... biomarkers collected in the context of clinical trials and ... precise or multi-targeted drug candidates, stratified patient selection and ... progression free survival. Highlighting the timing ...
(Date:4/20/2015)... ANGELES , April 20, 2015  "Everybody is ... we do to patients is frankly brutal. We,ve got ... in a cancer ward, or witnessed a loved one ... you,ve witnessed firsthand the devastation chemotherapy and other treatments ... most people want to give up and succumb to ...
(Date:4/20/2015)... 2015 /CNW/ - Portage Biotech Inc. ("Portage" or "the ... pleased to announce that its wholly owned subsidiary, Portage ... that showed one of its proprietary human-derived CPP sequences ... through inhibition of NFkB signalling even if administered when ... of the blood brain barrier (BBB) in mice was ...
(Date:4/20/2015)... 20, 2015   Meditope Biosciences, Inc ., a ... technology, today announced presentation of data demonstrating the use ... antibody-drug conjugates (ADCs). The data were presented in an abstract ... 18-22 in Philadelphia . ... point to the many commercial applications that may be ...
Breaking Biology Technology:PointCross Life Sciences and InterpretOmics partner for Clinical and Genomic Biomarker Management for Drug Development 2Is Dr. Craig Dionne the Steve Jobs of Cancer Research? 2Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 2Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 3Meditope Biosciences Presents Data At The American Association Of Cancer Research (AACR) Annual Meeting Validating Its SnAP Technology Platform 2
... IL - SecurePipe , a provider of ... an agreement to acquire the assets of Mycom's ... management technologies from Cincinnati-based Mycom Group, Inc. , ,SecurePipe ... sectors such as manufacturing, education, health care and financial ...
... Madison, Wis. - R&D Magazine has ... a 2005 R&D 100 Award, which recognizes the most ... past year. , ,The VANTEC-2000 system is an advanced ... science, materials science and nanotechnology research fields. It enables ...
... been utilized by thousands of U.S. companies since the ... fact, lawmakers in more than 35 states have introduced ... as an effective cost-cutting tool has begun to soar. ... offshore outsourcing, it was often viewed as ...
Cached Biology Technology:Consider the legal issues before outsourcing offshore 2Consider the legal issues before outsourcing offshore 3Consider the legal issues before outsourcing offshore 4Consider the legal issues before outsourcing offshore 5
... amber to slightly cloudy liquid. Yellow, ... per set, each containing 10 ml ... the following proportions by weight: 85% ... monooleate emulsifier), and 0.1% Mycobacterium ...
... been many modifications to the original formulas in ... still play an important role in tissue,culture. A ... and osmotic balance in the medium and to ... ions, is as valuable today as when it ...
Request Info...
... ion trap mass spectrometer enables high-throughput solutions ... LXQ linear ion trap mass spectrometer is ... delivering the fast cycle time and increased ... at an attractive price. The combination ...
Biology Products: