Navigation Links
Gold nanorods shed light on new approach to fighting cancer
Date:10/16/2007

WEST LAFAYETTE, Ind. - Researchers have shown how tiny "nanorods" of gold can be triggered by a laser beam to blast holes in the membranes of tumor cells, setting in motion a complex biochemical mechanism that leads to a tumor cell's self-destruction.

Tumor cell membranes often have an abnormally high number of receptor sites to capture molecules of folic acid, or folate, a form of vitamin B that many tumor cells crave. The Purdue researchers attached folate to the gold nanorods, enabling them to target the receptors and attach to the tumor cell membranes.

"The cells are then illuminated with light in the near-infrared range," said Ji-Xin Cheng (pronounced Gee-Shin), an assistant professor in Purdue's Weldon School of Biomedical Engineering. "This light can easily pass through tissue but is absorbed by the nanorods and converted rapidly into heat, leading to miniature explosions on the cell surface."

Scientists have recently determined that gold nanorods and other nanostructures can be used to target and destroy tumor cells, but it was generally assumed that cell death was due to the high heat produced by the light-absorbing nanoparticles. The Purdue team discovered, however, that a more complex biochemical scenario is responsible for killing the cells.

"We have found that rather than cooking the cells to death, the nanorods first punch holes in the membrane, and cell death is then chemically induced, in this case by an influx of calcium," said Alexander Wei, an associate professor of chemistry at Purdue.

Findings are detailed in a research paper appearing Oct. 19 in the journal Advanced Materials. The paper, which appeared online last week, was written by doctoral students Ling Tong, Yan Zhao, Terry B. Huff and Matthew N. Hansen, along with Wei and Cheng.

The gold rods are less than 15 nanometers wide and 50 nanometers long, or roughly 200 times smaller than a red blood cell. Their small size is crit
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Purdues gold nanorods brighten future for medical imaging
2. Researchers discover way to make cells in the eye sensitive to light
3. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
4. Bacteria collection sheds light on urinary tract infections
5. Sea skate experiment sheds light on human cell transport
6. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
7. McGill researchers shed light on formation of carcinogen in food
8. Scientists discover how plants disarm the toxic effects of excessive sunlight
9. Light therapy may combat fungal infections, new evidence suggests
10. Medical molecules designed to respond to visible light that can penetrate tissue
11. Genetic defects give the immune system the green light to attack the pancreas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 9, 2014  Acuity Market Intelligence today released forecasts from ... indicating that the global market for National Electronic ID (eID) ... 2018. During this time, the number of National eID cards ... Asia , with its vast population, will ... cards issued, while Europe trails a ...
(Date:7/10/2014)... Axinaea belongs to the large, mainly tropical flowering plant ... species in the family rely on bees for their pollination. ... insects or vertebrates. The flowers of Axinaea appear ... the petals of the different species are pink, yellow, orange ... on the contrasting colours of their bulbous appendages. The pollination ...
(Date:7/10/2014)... German . An ... a central step of photosynthesis in action for the first ... State University used the world,s most powerful X-ray flashlight at ... of a molecular complex called photosystem II as it splits ... oxygen in earth,s atmosphere. The researchers report their results in ...
Breaking Biology News(10 mins):National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2Novel type of bird pollination mechanism discovered in South America 2Scientists watch photosynthesis in action 2Scientists watch photosynthesis in action 3
... a land owner and animals such as coyotes or wild pigs ... way to control their numbers in a humane way in ... at Texas A&M Universitys College of Veterinary Medicine & Biomedical Sciences. ... baited food, researchers say. Researchers are testing oral contraceptives ...
... at the center of some of the nation,s most ... global climate change. To provide a critical overview of ... summit of leading energy experts from the government, research ... an Academies study under way called "America,s Energy Future: ...
... syndrome (FXS) is the most common hereditary form of ... attention deficit and/or hyperactivity disorder (ADHD), which complicates social ... such as Ritalin is often successfully used to treat ... is effective in children with mental retardation, it also ...
Cached Biology News:Texas A&M testing oral contraceptives for animals 2NAS to hold 2-day summit on energy issues 2Effective ADHD treatment found for children with fragile X syndrome 2
(Date:7/10/2014)... 10, 2014 Terascala, the industry leader ... Alan Swahn, a former vice president of product management ... vice president of marketing. Terascala’s software when combined with ... create the highest performance and most reliable solutions for ... guide Terascala’s channel expansion and broaden its product portfolio. ...
(Date:7/10/2014)... 10, 2014 Senior supply chain management ... associations, addressed the challenges of “Reducing Cost, Lead Time, ... through strategic sourcing. Describing the partnership of the Bio ... Chain Management Institute ( SCMI) of the University ... 24 at the Kroc Institute of Peace and Justice ...
(Date:7/10/2014)... 10, 2014 Research and Markets ( ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid ... report to their offering. ... of photonic integration traces its roots in the ... of photonic integration went unexplored and unfulfilled for ...
(Date:7/10/2014)... study published today in the journal PNAS (Proceedings ... that time of day and sleep deprivation have a ... crucial when looking at the best time of day ... disease, and for administering medicines effectively. , Researchers from ... Research, London, investigated the links between sleep deprivation, body ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2
... trails national averages in venture capital availability, but the ... detailed in a new report, NorthStar Guide to ... Inc. The report is subtitled, A sourcebook to growth ... Technology Network received an advance copy of the 60-page ...
... An Inquiry Into the Nature and Causes of The Wealth ... was the 18th century equivalent of todays (sanitized) bumper sticker: ... annual revenue of the society as great as he can, ... promote the public interest, nor knows how much he is ...
... joined Green Bays Nsight Telservices (www.nsighttel.com) in 2001 as ... action-packed stint as Chief Technical Officer (CTO) of Chicago ... Local Nsight, NET Cable, and NetNet and heads up ... Services (LMDS) deployment. , , WTN: How did ...
Cached Biology Technology:Growing Venture Capital in Wisconsin 2Growing Venture Capital in Wisconsin 3Wisconsin Economic Summits have given a hand to states progress 2Wisconsin Economic Summits have given a hand to states progress 3Interview: WTN Gets Real with Appletons Brad Hansen - Dot-Com Experience helps Executive to Spot Trends 2Interview: WTN Gets Real with Appletons Brad Hansen - Dot-Com Experience helps Executive to Spot Trends 3
... is an automated instrument with a thin ... real-time using light or fluorescence microscopy. Biaxial ... and fibroblast cells can be simulated by ... and Y axis of our strain chamber. ...
... regulate cell stretching or compression of a ... Computer controlled so you can precisely regulate ... to produce 64 unique strain parameters. ST-160 ... ST-150. Both models are compatible with Nikon, ...
... Glycosylation is a post-translational modification ... biological functions, including immune regulation, inflammation, ... Biotechnology has developed two lectin based ... and Wheat Germ Agglutinin (WGA), that ...
... activated carrier proteins to simplify the ... Activated Carrier Proteins are commonly used ... a heterobifunctional cross-linker (Sulfo-SMCC). This activation ... protein. Thus allowing the maleimide-activated ...
Biology Products: