Navigation Links
Gold nanoparticles help to develop a new method for tracking viruses
Date:1/15/2014

he mechanistic understanding of virus opening and the release of the viral genome in cellular structures for starting new virus production is still largely lacking. Furthermore, the knowledge of infectious processes in tissues is hampered by the lack of reliable tools for detecting virus infection.

The newly developed method involves a chemical modification of a known thiol-stabilized gold nanoparticle, the so-called Au102 cluster that was first synthesized and structurally solved by the group of Roger D Kornberg in 2007 (4) and later characterized at NSC by the groups of prof. Hannu Hkkinen and prof. Mika Pettersson in collaboration with Kornberg. (5) The organic thiol surface of the Au102 particles is modified by attaching linker molecules that make a chemical bond to sulfur-containing cysteine residues that are part of the surface structure of the virus. Several tens of gold particles can bind to a single virus, and the binding pattern shows up as dark tags reflecting the overall shape and structure of the virus (see the figure). The gold particles allow for studies on the structural changes of the viruses during their lifespan.

The study showed also that the infectivity of the viruses is not compromised by the attached gold particles which indicates that the labeling method does not interfere with the normal biological functions of viruses inside cells. This facilitates new investigations on the virus structures from samples taken from inside cells during the various phases of the virus infection, and gives possibilities to obtain new information on the mechanisms of virus uncoating (opening and release of the genome). The new method allows also for tracking studies of virus pathways in tissues. This is important for further understanding of acute and chronic symptoms caused by viruses. Finally, the method is expected to be useful for developing of new antiviral vaccines that are based on virus-like particles.

The method was develo
'/>"/>

Contact: Docent Varpu Marjomäki
varpu.s.marjomaki@jyu.fi
358-405-634-422
Academy of Finland
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Are silver nanoparticles harmful?
2. Hybrid copper-gold nanoparticles convert CO2
3. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
4. From pomegranate peel to nanoparticles
5. Palladium-gold nanoparticles clean TCE a billion times faster than iron filings
6. Paints and coatings containing bactericidal agent nanoparticles combat marine fouling
7. Oh, my stars and hexagons! DNA code shapes gold nanoparticles
8. Nanoparticles added to platelets double internal injury survival rate
9. Nanoparticles reboot blood flow in brain
10. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
11. Synthetic and biological nanoparticles combined to produce new metamaterials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gold nanoparticles help to develop a new method for tracking viruses
(Date:9/16/2014)... Proteins are responsible for practically all vital functions ... reactions, forward signals, transport particular substances and control ... that proteins do not function independently of each ... you examine the protein networks, you find many ... Falter-Braun from TUM,s Chair of Plant Systems Biology. ...
(Date:9/16/2014)... , Sept. 16, 2014  Cross Match ... management solutions, announced today the launch of its ... authenticate the identity of an individual using their ... Verifier Sentry rapidly reads credential documents with embedded ... by matching the biometric to a live scan ...
(Date:9/16/2014)... season of bounty. Fungi of dizzying variety erupt from ... search of elusive but delectable wild mushrooms. Part of ... hunt, and their mysterious not-quite-meat, not-quite-vegetable qualities that belie ... you are eating known to science? , The Fungi ... some estimates range up to 10 million species, only ...
Breaking Biology News(10 mins):Good networkers make prime targets 2Cross Match Launches New Identity Management Handheld Solution 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 3
... Slugs are every gardener,s enemy: They can destroy overnight, ... don,t like all plants in the same way they ... posed by the botanist and founder of Chemical Ecology, Ernst ... More than a hundred years later chemists from Friedrich-Schiller-University Jena ...
... hands and arms through innovative robotic and virtual reality-based video ... Sergei Adamovich, a biomedical engineer. Thanks to a ... Adamovich is developing better ways to rehabilitate people who have ... Preliminary laboratory results appear promising: ...
... 2010) Acidity is increasing in some regions of the ... ocean, where it is now recognized that increased levels of ... more acidic. These more acidic conditions in key parts of ... to new research published in the journal Estuaries and ...
Cached Biology News:Self-defense strategies of moss 2NJIT engineer helps stroke patients regain motor functions in hands, arms 2Changing Chesapeake Bay acidity impacting oyster shell growth 2Changing Chesapeake Bay acidity impacting oyster shell growth 3
(Date:9/16/2014)... --The emerging field of molecular electronics could take ... enabling the construction of tiny circuits from molecular ... would take on the roles currently played by ... of researchers from five Japanese and Taiwanese universities ... small-scale electronics: a molecule called picene. In a ...
(Date:9/16/2014)... Sept. 16, 2014 Cardioxyl Pharmaceuticals, Inc. ... has been shown to be effective in animal models ... alternative to intravenous infusions that could pave the way ... were presented yesterday at the Heart Failure Society of ... Las Vegas . The ...
(Date:9/16/2014)... Md. , Sept. 16, 2014   ... biotechnology company developing novel anti-infective biologic and drug ... and diseases, announced today the completion of the Company,s ... which highlighted its irritable bowel syndrome (IBS) ... constipation-predominant IBS (C-IBS). In the keynote ...
(Date:9/16/2014)... , Sept. 16, 2014 /PRNewswire-iReach/ -- Researchers found ... test identifies patients with bone fragility fracture when ... million people worldwide are at risk of fracture ... standard bone strength test, the DEXA bone density ... Society for Bone and Mineral Research Annual Conference ...
Breaking Biology Technology:The future face of molecular electronics 2Cardioxyl Presents Oral Heart Failure Treatment Data For Its Experimental HNO Prodrug At HFSA 18th Annual Scientific Meeting 2Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 2Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 3ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 3
... KNSY ) is scheduled to participate in a ... at the 2007 RBC Capital Markets,Healthcare Conference., Douglas ... panel,discussion on Thursday, December 13th at 8:00 a.m. ET ... York. The conference is by invitation only,however individuals can ...
... Promoting Advanced Technology,Industries Careers, HARRISBURG, Pa., ... from the Harrisburg area will continue learning ... special collaboration,between several local schools and the ... by the Harrisburg University of Science and,Technology, ...
... Dendreon Corporation (Nasdaq:,DNDN) today announced that the Company ... senior vice president of clinical affairs and chief ... a decade of oncology,drug development and patient treatment ... to the filing of the company,s Biologics License,Application ...
Cached Biology Technology:Capital Area Biotechnology Partnership Receives $160,000 State Investment 2Dendreon Promotes Dr. Mark Frohlich to Senior Vice President of Clinical Affairs and Chief Medical Officer 2Dendreon Promotes Dr. Mark Frohlich to Senior Vice President of Clinical Affairs and Chief Medical Officer 3
... a new technology for sensitive detection ... amounts of DNA (5). This process ... modify the DNA, followed by PCR ... distinguish methylated from unmethylated DNA. The ...
... m7G(5')ppp(5')G (Cap Analog) is used for the ... in vitro transcription reactions. Substitution of cap ... GTP in an in vitro transcription reaction ... structure into a large fraction of the ...
... The iEMS Incubator/Shaker HT ... Thus, the iEMS Incubator/Shaker HT ... as DNA hybridization and primer ... is available as a one-cabinet ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Biology Products: