Navigation Links
Gold nanoparticles help to develop a new method for tracking viruses
Date:1/15/2014

he mechanistic understanding of virus opening and the release of the viral genome in cellular structures for starting new virus production is still largely lacking. Furthermore, the knowledge of infectious processes in tissues is hampered by the lack of reliable tools for detecting virus infection.

The newly developed method involves a chemical modification of a known thiol-stabilized gold nanoparticle, the so-called Au102 cluster that was first synthesized and structurally solved by the group of Roger D Kornberg in 2007 (4) and later characterized at NSC by the groups of prof. Hannu Hkkinen and prof. Mika Pettersson in collaboration with Kornberg. (5) The organic thiol surface of the Au102 particles is modified by attaching linker molecules that make a chemical bond to sulfur-containing cysteine residues that are part of the surface structure of the virus. Several tens of gold particles can bind to a single virus, and the binding pattern shows up as dark tags reflecting the overall shape and structure of the virus (see the figure). The gold particles allow for studies on the structural changes of the viruses during their lifespan.

The study showed also that the infectivity of the viruses is not compromised by the attached gold particles which indicates that the labeling method does not interfere with the normal biological functions of viruses inside cells. This facilitates new investigations on the virus structures from samples taken from inside cells during the various phases of the virus infection, and gives possibilities to obtain new information on the mechanisms of virus uncoating (opening and release of the genome). The new method allows also for tracking studies of virus pathways in tissues. This is important for further understanding of acute and chronic symptoms caused by viruses. Finally, the method is expected to be useful for developing of new antiviral vaccines that are based on virus-like particles.

The method was develo
'/>"/>

Contact: Docent Varpu Marjomäki
varpu.s.marjomaki@jyu.fi
358-405-634-422
Academy of Finland
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Are silver nanoparticles harmful?
2. Hybrid copper-gold nanoparticles convert CO2
3. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
4. From pomegranate peel to nanoparticles
5. Palladium-gold nanoparticles clean TCE a billion times faster than iron filings
6. Paints and coatings containing bactericidal agent nanoparticles combat marine fouling
7. Oh, my stars and hexagons! DNA code shapes gold nanoparticles
8. Nanoparticles added to platelets double internal injury survival rate
9. Nanoparticles reboot blood flow in brain
10. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
11. Synthetic and biological nanoparticles combined to produce new metamaterials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gold nanoparticles help to develop a new method for tracking viruses
(Date:10/17/2014)... critical and pertinent for practicing physicians and clinicians given ... The Journal, Disaster Medicine and Public Health Preparedness ... Public Health, to surround the public, medical professionals and ... , On October 17, the journal published ... was prepared by Dr. Eric Toner, internist and emergency ...
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... new synthesis of recent research findings to inform their ... two states. , The Ecology and Management of ... Synthesis of the Relevant Biophysical Science and Implications for ... the U.S. Forest Service,s Pacific Northwest Research Station, is ... a synthesis of the large body of scientific information ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3New report synthesizes best available science on management of moist mixed-conifer forests 2
... cells can grow new extensions when the amount of three ... , The research examined three related receptor proteins, called ... of rats. , When researchers increased the amount ... up to three times longer than those on nerve cells ...
... the detrimental loss of sea ice sheets in ... the scientific community have been saying for years. Now ... of Earth and Environmental Science are turning their attention to ... having similar effects in the frigid Antarctic region. ...
... tumor cells implanted in mice have shown that the ... breast cancer to the lungs. The new studies by ... genes work together to promote the growth of primary ... cancerous cells to escape into the bloodstream and penetrate ...
Cached Biology News:3 proteins may play important role in nerve-cell repair 2UTSA researchers examine effects of global warming on Antarctic 2A genetic 'gang of 4' drives spread of breast cancer 2A genetic 'gang of 4' drives spread of breast cancer 3A genetic 'gang of 4' drives spread of breast cancer 4
(Date:10/22/2014)... According to new market research ... (Consulting, Integration, Deployment & Support), by Service Model ... Private, Others (Hybrid & Community)) - Global Forecast ... the Cloud Professional Services Market into various sub-segments ... It also identifies the drivers and restraints for ...
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
(Date:10/20/2014)... October 20, 2014 Convey Computer ... a team from Iowa State University won first place ... Using a Convey HC-2ex, the team’s solution achieved the ... faster than the second place finisher. , Experts from ... upon the month long challenge, using a variety of ...
(Date:10/20/2014)... GAITHERSBURG, Md. , Oct. 20, 2014  GenVec, Inc. ... Zola P. Horovitz , Ph.D., from its board of ... GenVec board in August 2003, and served as its chairman ... also served on the Nominating and Corporate Governance and Audit ... Zola for more than a decade of dedicated service to ...
Breaking Biology Technology:Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2
... Fla., Oct. 7 GeneWize Life Sciences ... Bulletin Board: GNLK) announced before a full house of ... targeting the teen market, adding to their current flagship ... The new nutrition and skin-clearing products, aimed ...
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Executive Officer of BioMarin, will host a ... 28, at 5:00 p.m. ET to discuss ... Dial-in Number:  866.202.3048International Dial-in Number:  617.213.8843Participant Code: ...
... JOSEPH, Mich., Oct. 7 GeneGo, Inc., a leading ... and chemistry, announced today that they have integrated GenomeQuest,s ... MetaDrug. Using GenomeQuest,s interactive analysis, scientists who ... of interest (hundreds of millions of reads, to thousands ...
Cached Biology Technology:GeneWize Announces New Skin Clearing Product and Teen Nutrition at Annual Convention 2BioMarin to Host Third Quarter 2010 Financial Results Conference Call and Webcast on Thursday, October 28 at 5:00 p.m. ET 2GeneGo Announces Integration With GenomeQuest for Pathway Analysis of Next Generation Sequencing Data 2
... The product contains 5 ... coated with the monoclonal BerEP4 ... EpCAM (epithelial cell adhesion molecule). ... samples of 2 x 10e7 ...
MOUSE ANTI HUMAN FACTOR I...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic use....
GFX PCR DNA,Gel Band Purif,100, 1 EA. Category: Nucleotide Sample Handling....
Biology Products: