Navigation Links
Gold nanoantennas detect proteins
Date:3/14/2012

Scientists at Johannes Gutenberg University Mainz (JGU) in Germany have developed a new method of observing individual proteins. Detailed knowledge of the dynamics of proteins is necessary in order to understand the related biological processes that occur on the molecular level. To date, this information has been obtained by means of labeling proteins with fluorescent substances, but unfortunately this changes the proteins under investigation and thus influences the biological processes that are to be observed. "Our method allows live tracking of individual proteins without having to label them first," explains Professor Dr. Carsten Snnichsen of the Institute of Physical Chemistry at JGU. "We are now gaining entirely new insights into molecular processes and can see, for example, how things are constantly in motion even on the very smallest scale."

The method developed by the group of Mainz chemists led by Carsten Snnichsen is based on the use of gold nanoparticles. These serve as glistening nanoantennas that, when they detect individual unlabeled proteins, slightly change their frequency or, in other words, their color. These tiny color changes can be observed using the technique developed in Mainz. "This is an enormous leap forward technologically: We have managed to achieve a very high time resolution for the observation of individual molecules," says Snnichsen. It is thus now possible to precisely observe the dynamics of a protein molecule down to the millisecond.

The opportunity to detect individual protein molecules also opens up completely new horizons. It has thus become practicable to track the fluctuation of protein population densities and observe protein adsorption processes in real time, among other things. "We can see how molecules move, how they dock at particular locations, and how they fold this has given us a window into the molecular world," explains Dr. Irene Ament, a member of Snnichsen's group. This new technology may prove to be useful not only in chemistry but also in medicine and biology.

The work is an important element in research into non-equilibrium phenomena at the molecular level and thus provides a solid foundation for the planned Cluster of Excellence Molecularly Controlled Non-Equilibrium (MCNE), which has been selected to enter the final round of the Excellence Initiative by the German federal and state governments to promote top-level research at German universities. Among other sources, the project received financial support in the form of an ERC Starting Grant for the project "Single metal nanoparticles as molecular sensors" (SINGLESENS).


'/>"/>

Contact: Carsten Soennichsen
carsten.soennichsen@uni-mainz.de
49-613-139-24313
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

Related biology news :

1. Optical nanoantennas enable efficient multipurpose particle manipulation
2. Photonic crystal biosensors detect protein-DNA interactions
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. Saliva proteins could help detection of oral cancer
5. Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
6. Sensitive nanowire disease detectors made by Yale scientists
7. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
8. Paradigm Tactical Products to be Largest Distributor of Metal/Radiation Detection Wands in United States
9. Men are better at detecting infidelities
10. Detecting tiny twists with a nanomachine
11. Nanoparticles in the home: More and smaller than previously detected
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... 2016 Research and Markets has announced the ... report to their offering. The ... to grow at a CAGR of 12.28% during the period ... an in-depth market analysis with inputs from industry experts. The report ... years. The report also includes a discussion of the key vendors ...
(Date:6/20/2016)... Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring announced that after ... secured the final acceptance by all three (3) ... Systems (MAS) installed. Furthermore, Securus will have contracts ... by October, 2016. MAS distinguishes between legitimate wireless ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:12/4/2016)... DIEGO , Dec. 3, 2016  In five ... of Hematology (ASH) Annual Meeting and Exposition in ... biomedical engineering methods to improve the delivery of life-saving ... These new methods are designed to carry therapies directly ... needed most, which could provide a substantial advantage over ...
(Date:12/2/2016)... THOUSAND OAKS, Calif. , Dec. 2, 2016 ... AGN ) today announced the submission of a ... for ABP 215, a biosimilar candidate to Avastin ® ... biosimilar application submitted to the EMA. "The ... milestone as Amgen seeks to expand our oncology portfolio," said ...
(Date:12/2/2016)... ... , ... Aerocom Healthcare ( http://www.aerocomhealthcare.com ), representing the global ... solution for tracking and securing medications at booth 676 at the ASHP Midyear ... has a proven solution for tracking medications via its system from pharmacy to ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... of pharmaceutical and biotechnology companies dedicated to collaboratively developing improved chemistry, manufacturing ... supplying a vendor-supported, portable online UHPLC, with robust, probe-based sampling. , ...
Breaking Biology Technology: