Navigation Links
Going to the dogs: University's newest patent for improving canine health
Date:11/29/2011

giving certain species certain resistances. For example, the immune system in dogs may be able to kill certain pathogens extremely well while the immune system in humans is not.

The team discovered different antimicrobial peptides in the dog but was most interested in canine cathelicidin, commonly abbreviated as K9CATH. Cathelicidins are peptides that play a central role in the early innate immunity against infections.

While animals like domestic cattle and buffalo have several different cathelicidins to help fight infections, dogs have only one type of cathelicidin peptide. This led the team to speculate that the sole cathelicidin in canines is extremely strong.

"Although a dog may be stronger immunologically speaking than a human and many other animals, it's not the strongest animal on Earth," Melgarejo said. "When I worked in the clinical sciences I regularly treated dogs for diarrhea, coughing, ear infections, dermatitis, conjunctivitis and other diseases. So it's evidently not as sturdy of an animal as it could be."

Because dogs are considered man's best friend, the researchers wanted to be dogs' best friend, too. Using the canine genome -- the genetic blueprint of the domestic dog -- the team applied the canine cathelicidin as a temple to develop a synthetic antimicrobial with enhanced biological activity.

Melgarejo and Blecha, along with Annika Linde, research associate, and Kate Osei-Boadi, a doctoral candidate in human nutrition, Ghana, are continuing to develop the synthesized cathelicidin as well as explore new avenues to strengthen it. This currently includes studying hyenas, which are one of the most resilient animals in nature.

Researchers are also in the process of establishing a partnership with the Kansas Bioscience Authority to test the synthesized peptide against canine leishmaniasis, which is a tropical disease that is on the rise. The disease is zoonotic, meaning that it spreads from dogs to
'/>"/>

Contact: Tonatiuh Melgarejo
tmelgare@k-state.edu
785-532-2730
Kansas State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Contract awarded for equipment to support on-going fish studies in the West
2. Is estrogen going to your head?
3. Going with the flow
4. Ongoing global biodiversity loss unstoppable with protected areas alone: Study
5. Going off the grid helps some bacteria hide from antibiotics
6. Food safety study of beef trim leads to ongoing research collaboration
7. Russian boreal forests undergoing vegetation change, study shows
8. Going green: New program provides vital support for plant scientists
9. Going out on a (redwood tree) limb
10. Keystone Symposia awarded $1.37 million, 5-year NIH grant to fund ongoing diversity efforts
11. Ongoing human evolution could explain recent rise in certain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... awarded the Oklahoma Medical Research Foundation a five-year, $14.5 ... the bacteria,s effects on humans. , For 10 ... have studied the human immune response to anthrax bacteria ... The original funding came soon after anthrax-laced letters killed ... terrorist attacks of Sept. 11, 2001. , The ...
(Date:8/20/2014)... the past few years, Virginia Tech,s Wu Feng has ... grant from the "Computing in the Cloud" program, and ... $6 million award from the Air Force on "big ... NSF and the National Institutes of Health on "big ... together the "parallel computing" aspects from each grant, he ...
(Date:8/20/2014)... for electronically manipulating the flight muscles of moths and ... those muscles. The work opens the door to the ... emergency response. , "In the big picture, we want ... moths for use in applications such as search and ... of electrical and computer engineering at NC State and ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4Research paves way for development of cyborg moth 'biobots' 2
... for creating chemical reactions between single molecules, scientists ... (NIST) have employed microfluidicsthe manipulation of fluids at ... molecules of interest. By combining this new microfluidic ... multiple droplets and cause their molecular contents to ...
... Researchers at the National Institute of Standards and ... other government agencies, have produced a new reference ... used as a hardener in high-performance alloys and ... fatal illness. The new reference material is expected ...
... that dust from a nearby construction zone will harm your ... confirm your suspicions or better yet, set your mind at ... Sandra Chudnovsky, of TAU,s Department of Geography have developed a ... ― to help families and authorities monitor the quality ...
Cached Biology News:New nanochemistry technique encases single molecules in microdroplets 2New beryllium reference material for occupational safety monitoring 2Tel Aviv University invention busts dust 2Tel Aviv University invention busts dust 3
(Date:8/21/2014)... VIEW, Calif. , Aug. 21, 2014 /PRNewswire/ ... properties and behaviors based on external stimuli such ... poised to have a disruptive effect in multiple ... revolutionize the business landscape by printing objects ranging ... aerospace and automotive sectors. Logo - ...
(Date:8/21/2014)... 21, 2014 Gallus BioPharmaceuticals ... development and manufacturing organization (CMO) announced today that ... an oncology company focused on the development of ... manufacture the anti-prostate specific membrane antigen (PSMA) monoclonal ... Under the agreement the antibody will be ...
(Date:8/20/2014)... Aug. 20, 2014 Clintrax Global, Inc., ... in Raleigh, NC , recently ... as Vice President of Administration. ... all corporate processes, including their alignment with company ... Brad worked as an HR executive, specializing in ...
(Date:8/20/2014)... time, chemists have succeeded in measuring vibrational motion of ... study reveals how vibration of a single molecule differs ... The study was performed at the University of California, ... of Jyvskyl works as a visiting fellow under professor ... The second team was lead by Professor Eric O. ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Clintrax Global, Inc. Announces Addition to Executive Team 2Seeing a molecule breathe 2
... Kingdom and GAITHERSBURG, Md., Oct. 29 /PRNewswire/,-- ... name to MedImmune to,reflect AstraZeneca,s vision for ... will unite the resources and expertise from ... activities within the AstraZeneca,Group, under the "MedImmune" ...
... the Innovator in,Ultrasound for more than 50 years, announced ... for advanced cardiac and,vascular imaging, the ProSound Alpha 10 ... American Heart Association, at the Orange County,Convention Center in ... 7 and the Alpha 10 incorporate all of the ...
... WaferGen Biosystems,Inc. (OTC Bulletin Board: WGBS), a ... and stem cell research systems,today announced that Mr. ... a corporate presentation at the Acumen BioFin Rodman,& ... be held,November 5 - 7, 2007, at the ...
Cached Biology Technology:AstraZeneca Bolsters Its Worldwide Biologics Division Through Integration of Cambridge Antibody Technology Into MedImmune 2ALOKA to Introduce New 'ProSound' Diagnostic Ultrasound Systems at the Scientific Session 2007 of American Heart Association, 4th to 7th of November 2007 in Orlando, Florida 2ALOKA to Introduce New 'ProSound' Diagnostic Ultrasound Systems at the Scientific Session 2007 of American Heart Association, 4th to 7th of November 2007 in Orlando, Florida 3WaferGen to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 2
Anti-GOSR2 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunocytochemistry, Immunoprecipitation, Western Blot...
... Synthetic peptide corresponding ... Antigen Family: ... Antigen Subfamily: not ... Recommended Storage: Long ...
Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: 4C...
... PROTEAN II xi 2-D system runs both gel dimensions ... tube gels can be separated in a single run ... cooling core in much the same manner as the ... the second-dimension slab gels may be cast in the ...
Biology Products: