Navigation Links
Going to the dogs: University's newest patent for improving canine health
Date:11/29/2011

giving certain species certain resistances. For example, the immune system in dogs may be able to kill certain pathogens extremely well while the immune system in humans is not.

The team discovered different antimicrobial peptides in the dog but was most interested in canine cathelicidin, commonly abbreviated as K9CATH. Cathelicidins are peptides that play a central role in the early innate immunity against infections.

While animals like domestic cattle and buffalo have several different cathelicidins to help fight infections, dogs have only one type of cathelicidin peptide. This led the team to speculate that the sole cathelicidin in canines is extremely strong.

"Although a dog may be stronger immunologically speaking than a human and many other animals, it's not the strongest animal on Earth," Melgarejo said. "When I worked in the clinical sciences I regularly treated dogs for diarrhea, coughing, ear infections, dermatitis, conjunctivitis and other diseases. So it's evidently not as sturdy of an animal as it could be."

Because dogs are considered man's best friend, the researchers wanted to be dogs' best friend, too. Using the canine genome -- the genetic blueprint of the domestic dog -- the team applied the canine cathelicidin as a temple to develop a synthetic antimicrobial with enhanced biological activity.

Melgarejo and Blecha, along with Annika Linde, research associate, and Kate Osei-Boadi, a doctoral candidate in human nutrition, Ghana, are continuing to develop the synthesized cathelicidin as well as explore new avenues to strengthen it. This currently includes studying hyenas, which are one of the most resilient animals in nature.

Researchers are also in the process of establishing a partnership with the Kansas Bioscience Authority to test the synthesized peptide against canine leishmaniasis, which is a tropical disease that is on the rise. The disease is zoonotic, meaning that it spreads from dogs to
'/>"/>

Contact: Tonatiuh Melgarejo
tmelgare@k-state.edu
785-532-2730
Kansas State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Contract awarded for equipment to support on-going fish studies in the West
2. Is estrogen going to your head?
3. Going with the flow
4. Ongoing global biodiversity loss unstoppable with protected areas alone: Study
5. Going off the grid helps some bacteria hide from antibiotics
6. Food safety study of beef trim leads to ongoing research collaboration
7. Russian boreal forests undergoing vegetation change, study shows
8. Going green: New program provides vital support for plant scientists
9. Going out on a (redwood tree) limb
10. Keystone Symposia awarded $1.37 million, 5-year NIH grant to fund ongoing diversity efforts
11. Ongoing human evolution could explain recent rise in certain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
(Date:4/27/2015)... OXFORD, Conn. , Apr. 27, 2015 ... "Company"), a biometric authentication company focused on the growing ... will commence shipping to pre-order customers the first week ... pre-orders through the month of May. ... is a significant milestone for the company as Wocket® ...
(Date:4/27/2015)... 27, 2015 Profile Solutions, Inc. (OTC: PSIQ), ... systems is pleased to announce that Dr Gerry ... and member of its scientific advisory board. ... a thought leader in technology-enhanced learning models. He was ... has published studies and books focused on online student ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... of how plants "breathe" may help us breed and select ... of Toronto study. , The paper, which offers the first ... surface pores, appears in the July 12 issue of Current ... and senior author Malcolm Campbell. "This is a gene that ...
... intense selective logging stopped in the region now ... guenon (Cercophithecus ascanius) is a primate still in ... new study, changed the ecological balance for these ... door for multiple parasitic infections. , The researchers ...
... sneak past the blood brain barrier, which protects the brain ... particularly invasive brain cancer, according to a new Saint Louis ... Academy of Sciences Online Early Edition the week of Aug. ... drugs into the brain, you can cure brain cancer," says ...
Cached Biology News:Genetic discovery could lead to drought-resistant plants 2Logging changed ecological balance for monkeys, damaged health 2Logging changed ecological balance for monkeys, damaged health 3Slipping past the blood brain barrier: Research shows potential treatment for brain cancer 2
(Date:4/30/2015)... (PRWEB) April 30, 2015 Available ... at http://www.lespausa.com , Fleur’s ... product combining the benefits of makeup, skin care ... subtly tinted cream is designed with specific complexion-correcting ... an even complexion and a healthy glow. Far ...
(Date:4/30/2015)... Cordova, CA (PRWEB) April 30, 2015 ... announced that Julie I. Morris has joined SureClinical’s executive ... is an experienced biotech and technology executive with over ... large Fortune 500 companies. , Ms. Morris joins ... ag biotech company. She was CFO of MBI from ...
(Date:4/30/2015)... 2015 Sterlitech is proud to ... PX, PY, and PZ Polyacrylonotrile (PAN) membranes ... Designed to be ideal for oil removal ... fill critical process requirements where the presence of ... “New regulations on industrial wastewater discharge and quality ...
(Date:4/29/2015)... BELLINGHAM, Washington, and BALTIMORE, Maryland, USA (PRWEB) April 29, ... premier event for photonics, optical sensing, and imaging on ... a place for government program managers, researchers, applications developers, ... and technology of sensing and imaging for multiple applications. ... -- defense and security, and commercial and scientific sensing ...
Breaking Biology Technology:Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3Julie I. Morris Joins SureClinical as Chief Financial Officer 2Sterlitech Offers New Ultrafiltration Membranes 2SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4
... able to charge their cell phones and other personal ... made by UC San Diego engineers could lead to ... In recent research, published in Applied Physics ... Department of Mechanical and Aerospace Engineering, along with graduate ...
... NeoStem, Inc. (NYSE Amex: NBS ), announced ... its shareholders, discussing the Company,s acquisition, on October 30, ... bio-pharmaceutical company based in the People,s Republic of China. ... Suzhou Eyre Pharmaceutical Co. Ltd., CHBP,s primary operating subsidiary ...
... ... and recognized refractive and cataract surgery experts listed at Trusted LASIK ... in vision correction surgery, cataract surgery, and ophthalmology in general at ... San Francisco, California. Dr. Richard Lindstrom, Dr. Shachar Tauber, Dr. David ...
Cached Biology Technology:Nanotube defects equal better energy and storage systems 2NeoStem Outlines to Shareholders Near-term and Long-term Business Strategies Following Acquisition of Chinese Pharmaceutical Company 2NeoStem Outlines to Shareholders Near-term and Long-term Business Strategies Following Acquisition of Chinese Pharmaceutical Company 3Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 2Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 3Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 4Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 5Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 6Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 7Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 8Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 9
Request Info...
... are cytopathic effect inhibition assays, also known as ... tissue culture supernatents; serum from PK studies and ... is defined as the quantity of interferon required ... viral infection by 50%. All standards ...
supplied with 10x reaction buffer...
... bioassays for interferons are cytopathic effect inhibition assays, ... Sample types include; tissue culture supernatents; serum from ... assays, one unit is defined as the quantity ... cytopathic effect of viral infection by 50%. ...
Biology Products: