Navigation Links
'Going off the grid' helps some bacteria hide from antibiotics
Date:4/25/2011

COLLEGE STATION, Texas, April 25, 2011 - Call them the Jason Bournes of the bacteria world.

Going "off the grid," like rogue secret agents, some bacteria avoid antibiotic treatments by essentially shutting down and hiding until it's safe to come out again, says Thomas Wood, professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University.

This surreptitious and elaborate survival mechanism is explained in the online April edition of Nature Chemical Biology, which details the research of Wood and his post doctoral student Xiaoxue Wang along with colleagues Breann Brown, Wolfgang Peti and Rebecca Page of Brown University.

"Through our research, we're understanding that some bacteria go to 'sleep,' and that antibiotics only work on bacteria that are metabolically active," Wood explains. "You need actively growing bacteria to be susceptible to antibiotics. If the bacterium goes to sleep, the antibiotics, no matter what they do, are not effective because the bacterium is no longer doing the thing that the antibiotic is trying to shut down."

It's an alternative method for survival, Wood says, that starkly contrasts the widely studied genetically based approaches utilized by bacteria through which bacteria gain resistance to antibiotics as the result of mutations experienced throughout time. This mutation-free response, however, demonstrates that some bacteria need not mutate to survive external stressors, Wood says.

Instead, when triggered by an external stressor such as an antibiotic, a bacterial cell can render itself dormant by triggering an internal reaction that degrades the effectiveness of its own internal antitoxins, Wood explains. With its antitoxins damaged, the toxins present within the bacterial cell are left unchecked and damage the cell's metabolic processes so that it essentially shuts down, he adds.

It's self-inflicted damage but with a purpose.

"The cell n
'/>"/>

Contact: Ryan Garcia
ryan.garcia99@tamu.edu
979-845-9237
Texas A&M University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Food safety study of beef trim leads to ongoing research collaboration
2. Russian boreal forests undergoing vegetation change, study shows
3. Going green: New program provides vital support for plant scientists
4. Going out on a (redwood tree) limb
5. Keystone Symposia awarded $1.37 million, 5-year NIH grant to fund ongoing diversity efforts
6. Ongoing human evolution could explain recent rise in certain disorders
7. Going green on hold: Man-made activities can affect blue haze, worlds weather
8. WPI receives $1.3 million in federal awards for ongoing research in the life sciences
9. A heart healthy diet and ongoing, moderate physical activity may protect against cognitive decline
10. Going bananas for sustainable research -- scientists create fuel from African crop waste
11. Lobster traps going high tech
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Ill. (September 30, 2014) People who suffer from ... do to control their asthma besides properly taking medications ... new article in the Annals of Allergy, Asthma ... College of Allergy, Asthma and Immunology (ACAAI), asthma sufferers ... their lifestyle. The woman described in the Annals article ...
(Date:9/29/2014)... 29: Between 1970 and 2010 populations of mammals, ... dropped 52 percent, says the 2014 Living Planet ... This biodiversity loss occurs disproportionately in low-income countriesand ... countries. , In addition to the precipitous decline ... other warning signs about the overall health of ...
(Date:9/29/2014)... to support the world,s needs to make cheaper ... new and more efficient catalytic materials and processes ... several from Wayne State University, is tackling this ... from the National Science Foundation. , The nearly ... Materials for Electrocatalytic Cascade Reactions," was to Eranda ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Half of global wildlife lost, says new WWF report 2Wayne State research aims to develop new, more efficient catalytic materials 2
... scientists are playing a major role in a NASA mission, ... layers beneath the surface of a comet. , NASA's Deep ... on 4th July, when a metre-long projectile will crash into ... crater and a plume of gas and dust. , UK ...
... to happen - you being in a car wreck or being ... greater killers win a free trip to the beach. It's really ... being in a wreck are far greater than being a shark's ... who has studied sharks for years. , Worldwide, about one million ...
... in a car wreck or being bitten by a shark? , ... trip to the beach. It's really no contest, says a Texas ... far greater than being a shark's lunch, says John McEachran, a ... years. , Worldwide, about one million people a year are killed ...
Cached Biology News:NASA probe could reveal comet life, scientists claim 2Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research 2Shark attack worries? Driving to the beach is more deadly 2
(Date:9/30/2014)... San Jose, California (PRWEB) September 30, 2014 ... generally measure the level of each type of cholesterol ... essential since the presence of excessive cholesterol levels in ... is a precursor condition to heart attack and other ... of fatality worldwide, therefore testing for cholesterol levels on ...
(Date:9/30/2014)... Basel, Switzerland (PRWEB) September 30, 2014 ... advanced software solutions for drug discovery and ... the FUNGITECT consortium has chosen Genedata Selector ... next-generation sequencing (NGS) data. FUNGITECT is a ... of invasive fungal diseases via individualized anti-fungal ...
(Date:9/30/2014)... FemCap Inc., www.femcap.com  an innovator in ... a patent No: US, 8,795,248 B2 dated Aug. 5, ... clearance in the U.S., 510(K) K121857, medical device licensure ... is related to its menstrual cup with a unique ... releasing FemmyCycle Teen, a third menstrual cup to complement ...
(Date:9/30/2014)... 2014 Lyme Research Alliance ... disease research at universities, today announced the awarding of ... identification, treatment and cure for Lyme and other tick-borne ... most applications in its history—over 20 grant proposals—a 100 ... were pleased to receive so many solid applications from ...
Breaking Biology Technology:Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3The FemmyCycle 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4
... Welcome to the event. Here extreme manufacturing meets extreme consumption. ... surplus raw materials. The remaining nations pray and hope that ... love. The trade imbalances are way out of synch; envy ... the two odd nations. , ,Somewhere out there is ...
... be encouraged by the numerous positive signs that biotech is ... few: , ,& bull; The coming of the Olympics of ... continued acquisition of Midwest biotech companies by Big Pharma ... products and technology, the flip side of this is that ...
... University of Wisconsin-Madison faculty have created a new dual-degree ... students how to apply such knowledge to problems in ... and aggression," says Clark Miller, a professor of science ... the new program. "Or what about brain mechanisms that ...
Cached Biology Technology:The world's largest factory 2The world's largest factory 3The world's largest factory 4Midwest biotech on a roll 2Midwest biotech on a roll 3Midwest biotech on a roll 4UW offers new program in neuroscience and public policy 2