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Going live with click chemistry
Date:10/30/2007

ent, a substituted cyclooctyne, possesses ring strain and electron-withdrawing fluorine substituents that together promote the cycloaddition with azides installed metabolically into biomolecules, said Bertozzi.

This copper-free click reaction of azides and DIFO combines the biocompatibility of the Staudinger ligation [a highly successful labeling reaction previously developed in Bertozzis lab] with the fast reaction kinetics of click chemistry.

Bertozzi says their copper-free click chemistry technique can be used to probe any biomolecule that can be labeled with an azide, including glycans, proteins and lipids. She and her group are now using this technique to study glycan trafficking how glycans and their associated scaffolds move around inside cells and on cell surfaces. They have made their DIFO reagents available to other research groups and are in discussions with potential commercial suppliers to make the reagents widely available to the bio research community.

Direct imaging of glycan trafficking under conditions of cell stimulation or pharmacological intervention can be performed in cells, tissues, or even whole organisms, said Bertozzi. More broadly, other metabolites, post-translational modifications, enzyme activities, and site-specific labeled proteins can be monitored in real time and in living systems with our copper-free click chemistry.


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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory  
Source:Eurekalert

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