Navigation Links
Go figure: Math model may help researchers with stem cell, cancer therapies
Date:1/20/2011

The difficult task of sorting and counting prized stem cells and their cancer-causing cousins has long frustrated scientists looking for new ways to help people who have progressive diseases.

But in a development likely to delight math teachers, University of Florida researchers have devised a series of mathematical steps that accomplishes what the most powerful microscopes, high-throughput screening systems and protein assays have failed to do assess how rapidly stem cells and their malignant, stemlike alter egos increase their numbers.

The method, published in the online journal PLoS ONE in January, may rev up efforts to develop stem cell therapies for Alzheimer's, Parkinson's and other diseases. It may also help get to the root of the cancer-stem cell theory, which puts forth the idea that a tiny percentage of loner cancer cells gives rise to tumors.

"Math is going to be the new microscope of the 21st century because it is going to allow us to see things in biology that we cannot see any other way," said Brent Reynolds, Ph.D., an associate professor of neurosurgery at UF's McKnight Brain Institute and a member of the UF Shands Cancer Center. "Stem cells and the cells that drive cancer may be as infrequent as one in 10,000 or one in 100,000 cells. The problem is how do you understand the biology of something whose frequency is so low?"

Inspired by a 2004 essay by Joel E. Cohen, Ph.D., of The Rockefeller University and Columbia University that described the explosive synergy between mathematics and biology, Reynolds and postdoctoral associate Loic P. Deleyrolle set out to build an algorithm that could determine the rate stem cells and cancer stem cells divide.

High hopes to treat or prevent diseases have been pinned on these indistinguishable cells, which are often adrift in populations of millions of other cells. Scientists know stem cells exist mainly because their handiwork is everywhere tissues heal and regenerate because of stem cells, and somehow cancer may reappear years after it was thought to be completely eliminated.

With Geoffrey Ericksson, Ph.D., a computational neuroscientist at the Queensland Brain Institute, and other scientists in Australia, the team proposed a mathematical interpretation of neurospheres tiny collections of brain cells that include stem cells and their progeny at different stages of development.

They tested the mathematical approach by using brain tumor and breast tumor cells in cultures and in mice, correlating the estimates generated by the mathematical model with the aggressiveness of the cells they were studying.

"The unique thing about our study is we were able to do the biology," Deleyrolle said. "We took our simulation to the real world with real cells."

By offering a method to evaluate the effects of diseases and treatments on stem cell activity in the brain, as well as allowing the assessment of malignant stemlike cells, researchers believe they can better evaluate potential therapies for diseases.

"Estimating the numbers of stem cells one has in a particular tissue or culture has important implications in the development of therapeutics, including those for brain tumors," said Harley Kornblum, M.D., Ph.D., professor in residence at the Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles, who was not involved with the study. "This method provides a mathematical model that will enable researchers to do just that. Certainly, it will help my own research in these areas a great deal."


'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Related biology news :

1. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
2. Models of eel cells suggest electrifying possibilities
3. Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
4. Swamping bad cells with good in ALS animal models helps sustain breathing
5. Moderate use averts failure of type 2 diabetes drugs in animal model
6. Multiple sclerosis research charges ahead with new mouse model of disease
7. A model to measure soil health in the era of bioenergy
8. New model predicts hot spots for mercury in fish
9. New movement models tested at the Smithsonian in Panama
10. Cytori reports benefit of adipose-derived regenerative cells in spinal disc model
11. Lifecycles of tropical cyclones predicted in global computer model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market is ... next decade to reach approximately $14.21 billion by 2025. ... all the given segments on global as well as regional levels ...
(Date:3/20/2017)... 20, 2017 PMD Healthcare announces the release ... Wellness Management System (WMS), a remote, real-time lung health ... PMD Healthcare is a Medical Device, Digital Health, and ... to creating innovative solutions that empower people to improve ... focus, PMD developed the first ever personal spirometer, Spiro ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... WonderWorks, Myrtle ... to showcase the future of deep space exploration and inspire space enthusiasts. The ... spacecraft and includes a guest appearance by former Shuttle Astronaut Don Thomas. , ...
(Date:4/26/2017)... Hong Kong (PRWEB) , ... April 26, 2017 ... ... be hosted in EMEA and North America this May ... from May 16-18 , Donald H. Taylor, Chairman of the Learning and Performance ...
(Date:4/25/2017)... ... 2017 , ... Franz Inc ., an early innovator ... market leader for Semantic Graph Database technology, today announced Allegro ... effective system for developing and deploying applications to solve the challenges developers face ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... Metrology Partners.     , Covalent’s Analytical Services unit provides high-quality data to ... measured within 24 hours of receipt. There are no price premiums, and customers ...
Breaking Biology Technology: