Navigation Links
Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
Date:5/2/2012

Collaborative research by groups headed by scientists Joan J. Guinovart and Marco Miln at the Institute for Research in Biomedicine (IRB Barcelona) has revealed conclusive evidence about the harmful effects of the accumulation of glucose chains (glycogen) in fly and mouse neurons. These two animal models will allow scientists to address the genes involved in this harmful process and to find pharmacological solutions that allow disintegration of the accumulations or limitation of glycogen production. Advances in this direction would make a significant contribution to investigation into Lafora progressive myoclonic epilepsy and other neurodegenerative diseases characterized by glycogen accumulation in neurons. The journal EMBO Molecular Medicine publishes the results of the study this week.

"Our data clearly indicate that glycogen accumulation alone kills neurons and thus dramatically reduces lifespan", explains Guinovart, an expert in glycogen metabolism, group leader at IRB Barcelona, and senior professor at the University of Barcelona, "because the only thing we have manipulated in the neurons is their capacity to produce glycogen".

The inclusion of the Drosophila fly in the study provides in vivo confirmation of the theory in another animal model as these flies also show the same symptoms of degeneration as mice when glycogen accumulates in neurons. However, in addition the use of Drosophila will speed up obtaining genetic data and the screening of therapeutic molecules. "In a short time we will be able to perform a massive search for genes involved in the pathological process and to understand it better at the molecular level", emphasizes Marco Miln, ICREA researcher at IRB Barcelona and a specialist in Drosophila. "But the flies will also be useful to identify pharmacological molecules that can cure", he explains.

The IRB Barcelona teams are designing several experiments to identify the possible therapeutic targets that may be useful to prevent glycogen accumulation in neurons. In addition to the direct relation to Lafora epilepsy, a progressive degenerative disease that affects adolescents and has no cure, glycogen accumulation could be the main cause of other neurodegenerative illnesses such as Adult polyglucosan body disease and Andersen's disease.


'/>"/>

Contact: Sonia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
2. Resveratrol prevents fat accumulation in livers of alcoholic mice
3. Tracking poultry litter phosphorus: Threat of accumulation?
4. A balanced protein diet can reduce accumulation of nitrogen on dairy cattle farms by up to 35 percent
5. Mountain pine beetle activity may impact snow accumulation and melt, says CU-Boulder study
6. Stabilizing force for good communication between neurons and muscle cells found
7. Mediator in communication between neurons and muscle cells found
8. Protecting neurons could halt Alzheimers, Parkinsons diseases
9. How mirror neurons allow us to learn and socialize by going through the motions in the head
10. Researchers generate functional neurons from somatic cells
11. UCLA stem cells scientists make electrically active motor neurons from iPS cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
Breaking Biology News(10 mins):
(Date:5/18/2016)... -- The Biotech industry continues to face a ... are no opportunities ahead. Today, ActiveWallSt.com has on its list ... ), Seattle Genetics Inc. (NASDAQ: SGEN ), Chiasma ... OPHT ). Sign up now to receive our ... Threshold Pharmaceuticals Inc.,s shares gained 0.68%, closing ...
(Date:5/18/2016)... Muncie, IN (PRWEB) , ... May 18, 2016 , ... ... 1970, and is now celebrating its dream of reaching a total of $1 million ... in scholarships awarded to 10 high school graduates from across the nation has helped ...
(Date:5/17/2016)... ... May 17, 2016 , ... DryLet, ... reduction applications, announced today it will be showcasing ManureMagic™ at booth V1061 at ... featured in the Wall Street Journal last year and more recently made news ...
(Date:5/17/2016)... ... May 17, 2016 , ... The Children’s Tumor Foundation is enthusiastic to announce ... will show their support in the fight against neurofibromatosis (NF) by lighting up blue ... disorder that causes tumors to grow on nerves throughout the body. It affects 1 ...
Breaking Biology Technology: