Navigation Links
Glue inside the cell
Date:10/19/2007

The acquired immune response is triggered after specific engagement of foreign peptides (antigens) by receptor molecules on white blood cell (lymphocytes). Cellular signaling pathways are responsible for the activation of lymphocytes. Krappmann and co-workers present evidence, that in T cells, which constitute a subgroup of lymphocytes, ubiquitin is attached to the Malt1 protein in response to antigen stimulation. Malt1 is part of the CBM (Carma1-Bcl10-Malt1) complex that constitutes a crucial switch for the activation of the immune defense. Using biochemical, molecular and genetic techniques the scientists could prove that this novel Malt1 ubiquitination is an essential step in the regulation of T cell activation.

Mechanistically, ubiquitin is virtually acting as all-purpose glue that links different protein components inside the cell, Krappmann explains. However, ubiquitination provides an important advantage compared to conventional adhesives: It is reversible, meaning that the associations can be resolved.

This process of de-ubiquitination is constantly happening in cells and it could contribute to prevent an over-shooting activation of T cells. Unopposed lymphocyte activity is responsible for many chronic diseases, autoimmunity or even lymphoma development. Future work must address the status of Malt1 ubiquitination under pathological conditions, for instance in Malt1 dependent lymphomas. By this the scientists hope to demonstrate the potential of targeting the ubiquitin system for the development of novel therapeutic approaches.


'/>"/>

Contact: Heinz Joerg Haury
oea@gsf.de
49-893-187-2460
GSF - National Research Center for Environment and Health
Source:Eurekalert

Page: 1

Related biology news :

1. Nano-Probes Allow an Inside Look at Cell Nuclei
2. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
3. Scientists reveal how disease bacterium survives inside immune system cell
4. The molecular post office inside the cell
5. Sleeping sickness parasite shows how cells divide their insides
6. Cellular scale drug delivery from the inside out
7. Common bacteria pirate natural mechanism to get inside cells
8. Clues to breast cancer hidden inside stem cells
9. Inside rocks, implications for finding life on Mars
10. Tiny shock absorbers help bacteria stick around inside the body
11. Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... June 20, 2017 , ... Biologist Dawn Maslar MS has found ... latest book, Men Chase, Women Choose: The Neuroscience of Meeting, Dating, Losing Your Mind, ... effect on men. ”The logical next step, in my estimation, was to scientifically track ...
(Date:6/20/2017)... ... June 20, 2017 , ... GigaGen Inc ... millions-diverse immune repertoires, announces launch of its new Surge(TM) Discovery service ... CEO of GigaGen, will present on Surge at the conference. , Surge is ...
(Date:6/16/2017)... , ... June 16, 2017 , ... ... compliance and commercialization, has just announced two more sessions of its “From the ... will focus on the world of online templates for design control exercises. Led ...
(Date:6/15/2017)... ... June 15, 2017 , ... The ... an artist’s journey through creative experimentation and interdisciplinary collaboration. Feature Creep, a solo ... 22nd. An opening reception will be held at EKG, located at 3600 Market ...
Breaking Biology Technology: