Navigation Links
Glue inside the cell
Date:10/19/2007

The acquired immune response is triggered after specific engagement of foreign peptides (antigens) by receptor molecules on white blood cell (lymphocytes). Cellular signaling pathways are responsible for the activation of lymphocytes. Krappmann and co-workers present evidence, that in T cells, which constitute a subgroup of lymphocytes, ubiquitin is attached to the Malt1 protein in response to antigen stimulation. Malt1 is part of the CBM (Carma1-Bcl10-Malt1) complex that constitutes a crucial switch for the activation of the immune defense. Using biochemical, molecular and genetic techniques the scientists could prove that this novel Malt1 ubiquitination is an essential step in the regulation of T cell activation.

Mechanistically, ubiquitin is virtually acting as all-purpose glue that links different protein components inside the cell, Krappmann explains. However, ubiquitination provides an important advantage compared to conventional adhesives: It is reversible, meaning that the associations can be resolved.

This process of de-ubiquitination is constantly happening in cells and it could contribute to prevent an over-shooting activation of T cells. Unopposed lymphocyte activity is responsible for many chronic diseases, autoimmunity or even lymphoma development. Future work must address the status of Malt1 ubiquitination under pathological conditions, for instance in Malt1 dependent lymphomas. By this the scientists hope to demonstrate the potential of targeting the ubiquitin system for the development of novel therapeutic approaches.


'/>"/>

Contact: Heinz Joerg Haury
oea@gsf.de
49-893-187-2460
GSF - National Research Center for Environment and Health
Source:Eurekalert

Page: 1

Related biology news :

1. Nano-Probes Allow an Inside Look at Cell Nuclei
2. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
3. Scientists reveal how disease bacterium survives inside immune system cell
4. The molecular post office inside the cell
5. Sleeping sickness parasite shows how cells divide their insides
6. Cellular scale drug delivery from the inside out
7. Common bacteria pirate natural mechanism to get inside cells
8. Clues to breast cancer hidden inside stem cells
9. Inside rocks, implications for finding life on Mars
10. Tiny shock absorbers help bacteria stick around inside the body
11. Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
(Date:1/28/2016)... Synaptics (NASDAQ: SYNA ), a leading developer of human interface ... 31, 2015. --> --> ... percent compared to the comparable quarter last year to $470.5 million. ... million, or $0.93 per diluted share. --> ... of fiscal 2016 grew 9 percent over the prior year period ...
(Date:1/22/2016)... , January 22, 2016 /PRNewswire/ ... announced the addition of the  "Global ... their offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... Texas (PRWEB) , ... February 10, 2016 , ... ... centers across three states, announced today the promotion of two long-standing principal investigators ... Chief of Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, a ...
(Date:2/10/2016)... ... ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their new high-speed ... Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS Expo on ... diode standard packages feature a TO-46 metal can with active areas of 1.0mm and ...
(Date:2/10/2016)... ... 10, 2016 , ... PatientCrossroads announces that the ... online PatientCrossroads platform, has exceeded both its one-year and overall recruitment goals since ... which seeks to advance understanding of the hereditary risks for certain kinds of ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... has announced a new agreement with Singapore-based Global Stem Cells Network (GSCN) and ... Philippines, Thailand and Singapore in the latest adipose and bone marrow therapies. ...
Breaking Biology Technology: