Navigation Links
Glucose: Potential new target for combating annual seasonal influenza
Date:12/15/2013

by the cell's vacuolar-type H+ ATPase (V-ATPase) proton pump. The researchers found that this dependence could be used to manipulate the infection's success.

Dr. Adamson and Kohio boosted glucose concentrations in the laboratory cell cultures, and influenza infection rate concomitantly increased. Treating the viral cells with a chemical that inhibits glucose metabolism significantly decreased viral replication in the lab cultures. The researchers also demonstrated that the infection could be restored to high levels simply by adding ATP, the major source of energy for cellular reactions, bypassing the need for glucose.

Looking closer, they discovered that higher levels of glucose promoted the assembly of the V-ATPase proton pump that drives the release of the influenza A genome into the cytoplasm, the internal watery environment of the cell.

When Dr. Adamson and Kohio added the glucose inhibitor to the cell cultures, the assembly of the molecular pump was suppressed. Viral infection, they concluded, was closely tied to the assembly of the V-ATPase pump, and this dependence could be used to manipulate infection success.

Specifically, they were able to suppress viral infection of cells by dismantling the V-ATPase through the lowering of glucose levels. In addition, they inhibited infection by treating cells with chemical inhibitors of glycolysis, the initial pathway of glucose catabolism. Conversely, influenza viral infection of cells could be increased by giving cells more glucose than normal, the researchers report in the journal Virology, http://www.ncbi.nlm.nih.gov/pubmed/23876457.

The ease with which the researchers could dial viral infection down by controlling glucose levels and thus V-ATPase activity suggested a new strategy for throttling influenza viral infection.

"Taken together, we propose that altering glucose metabol
'/>"/>

Contact: Cathy Yarbrough
cyarbrough@ascb.org
858-243-1814

John Fleischman
jfleischman@ascb.org

American Society for Cell Biology
Source:Eurekalert


Page: 1 2 3

Related biology news :

1. Wayne State discovers potential treatment for skin and corneal wound healing in diabetics
2. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
3. Morphing material has mighty potential
4. Study examines potential evolutionary role of sexual regret in human survival and reproduction
5. Biometric-Mobile Wallet Technology Takes Aims at a Target Market Of Nearly $1Billion Potential
6. New research finds potential risk for millions in Africa believed resistant to vivax malaria
7. Potential drug target in sight for rare genetic disease
8. Researcher finds potential new use for old drugs
9. Bold new partnership launches to harness potential of data scientists and big data
10. Research reveals new understanding, warning signs, and potential treatments for multiple sclerosis
11. Research points to potential window for treating CMV and preventing mother-to-child transmission
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Biometrics Technology Market - Industry Analysis Size Share Growth ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... has created a need for high level security in ... personnel authentication such as username and passwords, tokens etc. ...
(Date:7/11/2014)... de Janeiro, Brazil- In the brains of all ... that allows an electric or chemical signal to ... Chemical synapses, which are the most abundant type ... Synapse formation is crucial for learning, memory, perception ... inhibitory synapses critical for brain function. For ...
(Date:7/10/2014)... 27, 2014  The American Academy of Forensic ... Standards and Technology (NIST) and the Department of ... and forensic science expert members to the Forensic ... element of the NIST,s Organization of Scientific Area ... first appointments made to the new FSSB that ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... plants to build new organs throughout their whole life. ... factors work together to prevent plants from having growth ... from the Max Planck Institute for Developmental Biology have ... and a regulatory protein, which controls the number of ...
... flu did you get? TIGR scientists survey five New York ... season, scientists at The Institute for Genomic Research (TIGR) have ... this week's journal Nature , the researchers report the ... offers a unique snapshot of the rapidly evolving flu virus ...
... infected with HIV in the UK have one of the ... the world, prompting fears of a second wave epidemic of ... , The study authors are concerned that the large reductions ... were given combinations of drugs (combination antiretroviral therapy) may be ...
Cached Biology News:Max Planck researchers make a breakthrough in plant stem cell research 2Max Planck researchers make a breakthrough in plant stem cell research 3First big influenza genome study reveals flu evolution 2First big influenza genome study reveals flu evolution 3First big influenza genome study reveals flu evolution 4HIV drug resistance increasing in UK and among highest in the world 2
(Date:7/11/2014)... July 11, 2014 Cayenne Medical, ... specializing in the soft tissue reconstruction segment, announced ... System for surgeries involving the shoulder and extremities. ... a novel, inserter-controlled deployment method. The unique delivery ... deployment, anchor pull-out, or anchor displacement (also commonly ...
(Date:7/10/2014)... Toronto, Canada (PRWEB) July 10, 2014 ... often present in very low abundance and are ... quite challenging and time-consuming. , Join presenters Dr. ... Laboratories, and Dr. John Anders, Head of Quality ... mass spectrometer-based approach that can speed detection and ...
(Date:7/10/2014)... Understanding the need for better quality and higher ... that currently exists in this area, ChanTest has recently ... validated ion channel and GPCR cell lines. ChanTest’s ... channels control many critical physiological functions throughout the body. ... to treat a variety of human diseases. , ...
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... Madison, Wis. - On Sand Hill Road in Menlo ... Street, the talk these days is of a "boomlet" in ... lucky to get a meeting with a venture capitalist are ... Times reported last week that one company, XenSource, had seven ...
... common practice for programmers to find readily available source code ... the software they are developing. Using open source software (OSS) ... many misconceptions about OSS, and the legal ramifications that can ... know that OSS is not "free" software in the usual ...
... growing at its present rate employees may not even need ... channel manager for Cisco Systems. , ,The manager, ... program, saying the surging interest in wireless communications could be ... With costs falling and enhancements increasing, mobility has become the ...
Cached Biology Technology:Wisconsin early-stage companies must position themselves to get capital 2Wisconsin early-stage companies must position themselves to get capital 3Open source software -- Managing the legal risks 2Open source software -- Managing the legal risks 3Cisco manager touts wireless advantages 2
... any of UVP's Doc-It systems. When further ... Analysis software onto your existing computer. ... and enhancement tools. Doc-It 1D Analysis Software ... for quick and accurate electrophoresis analysis., ...
CQCS kit for first KR 4i , (first unit)....
... Multidrop Combi is a new generation dispenser ... dispensing with the proven performance of the existing ... cover large volume area starting from 500 nl ... the range. ,It is optimized for ...
Multidrop Micro high speed 1 l bulk reagent dispenser rapidly, precisely and accurately dispenses microvolumes of 1-50 l into 384- and 96-well microplates....
Biology Products: