Navigation Links
Glucocorticoid treatment may prevent long-term damage to joints
Date:9/2/2011

Joint injury can result in irreversible damage of cartilage which, despite treatment and surgery, often eventually leads to osteoarthritis (OA) in later life. New research published in BioMed Central's open access journal Arthritis Research & Therapy demonstrates that short term treatment of damaged cartilage with glucocorticoids can reduce long term degenerative changes and may provide hope for prevention of OA after injury.

A normal joint is covered by a layer of cartilage containing proteoglycans such as aggrecan and lubricating fluid containing glycosaminoglycans (GAG) such as hyaluronic acid. In a double whammy, after injury proteoglycans and other molecules in cartilage begin to break down and the synthesis of these proteoglycans within cartilage is reduced. Additionally proinflammatory cytokines such as TNFα, IL-1β, and IL-6 are released into the synovial fluid after injury and further increase GAG loss from cartilage.

Using a 'worst-case scenario' system in which cartilage was subjected to mechanical injury and bombarded with immune system-stimulating bio-molecules (TNFα and IL-6) the glucocorticoid dexamethasone (DEX) was able to reduce GAG loss and restore proteoglycan synthesis levels to normal.

Prof Alan Grodzinsky from the MIT Center for Biomedical Engineering said, "Glucocorticoid injections are sometimes used to relieve the pain of established osteoarthritis, but there are concerns about long-term use. Our results suggest that short-term glucocorticoid treatment after joint injury may help restore components of cartilage to preinjury levels and consequently may prevent the long term changes which lead to osteoarthritis."


'/>"/>

Contact: Guy Melzack
guy.melzack@biomedcentral.com
020-319-22363
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment
2. International pharmacogenomics conference to focus on better drug treatment based on genetics
3. UH researchers explore treatments for breast and colon cancers
4. Joslin researchers identify new target for treatment of type 2 diabetes and prediabetes
5. Researchers on the trail of a treatment for cancer of the immune system
6. Researchers find new hope for treatment of chronic leukemia
7. Popular herbal supplements may adversely affect chemotherapy treatment
8. NYU Langone researchers identify a signaling pathway as possible target for cancer treatment
9. BUSM professor awarded $13.3 million to study potential treatments to prevent STDs
10. Wayne State researcher discovers antibiotic useful for localized treatment of bone wear
11. No treatment is the best treatment -- diarrhea in young foals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... data from over 18,000 patients, scientists have identified ... in Parkinson,s disease, including six that had not ... Nature Genetics , was partially funded by the ... scientists working in NIH laboratories. , "Unraveling the ... the multiple mechanisms involved in this complex disease, ...
(Date:7/25/2014)... colonial era, 100,000s of people lived on the land ... fire to control the availability of plants they used ... to use fire to maintain desired habitat and natural ... Forest Service,s Pacific Southwest Station, will lead a ... Refuge during the Ecological Society of America,s 99th Annual ...
(Date:7/25/2014)... raging this summer and some of the smoke from those ... image collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... smoke has descended over the Great Lakes region of the ... image from July 23, 2014 (first image feature highlighted below) ... off southeastward. In the image, it is over Manitoba ...
Breaking Biology News(10 mins):NIH scientists find 6 new genetic risk factors for Parkinson's 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... never reach the tumors they,re intended to treat, ... the blood vessels feeding the tumors are abnormal"leaky ... Judah Folkman, MD, founder of the Vascular Biology ... researchers have discovered an explanation for these abnormalities ...
... 75% of fertilizers and fertilizer technology used around the ... to 1970s by scientists and engineers at the Tennessee ... Shields, a former TVA official. Shields is now Interim ... and Agricultural Development, based in Muscle Shoals, Alabama. ...
... A group of Yale undergraduates have discovered dozens of ... the Amazon rain forest, including several so genetically distinct ... taxonomical genera. The analysis of 135 endophytes - ... of plants - by members of the Rain Forest ...
Cached Biology News:Normalizing tumor vessels to improve cancer therapy 2Normalizing tumor vessels to improve cancer therapy 3TVA fertilizer technology used worldwide -- but few new products since 1970s 2TVA fertilizer technology used worldwide -- but few new products since 1970s 3TVA fertilizer technology used worldwide -- but few new products since 1970s 4Yale undergrads' Amazon trip yields a treasure trove of diversity 2
(Date:7/28/2014)... (PRWEB) July 28, 2014 The National ... in Muncie IN, is pleased to announce that it ... National Museum of the United States Air Force. , ... year-long process that concluded this spring with an on-site ... Dayton, OH museum. , The National Museum of ...
(Date:7/25/2014)... July 26, 2014 "Ischemic Stroke ... 2014" provides data on the Ischemic Stroke and ... elemental information and data relating to the clinical ... View full global Ischemic Stroke Research Report 2014 ... overview of the trial numbers and their recruitment ...
(Date:7/25/2014)... live in each person,s digestive tract. Scientists believe that ... off harmful infections, but their role in human health ... on the role of these bacteria, a team of ... tracked fluctuations in the bacterial populations of two research ... the July 25 issue of the journal Genome ...
(Date:7/25/2014)... , July 25, 2014 ... the "Global Metabolomics Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics is ... Metabolomics has become a new experimental technique that ... the environmental sciences. Metabolites are small molecules that ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... Supports Program to Recognize Exemplary Work, BRIDGEWATER, ... of oncology nurses, Ortho Biotech Products, L. P.,today ... Healer,Award for Oncology Nursing, which honors one of ... their unwavering,dedication, compassion and helpfulness. Last year, more ...
... Exclusive Rights to Oncology Biomarkers, FREMONT, ... VRML ), a high-value molecular diagnostics company, ... with Johns Hopkins University,on the development of ... disease,detection, classification and monitoring of prevalent cancers, ...
... Pharmaceuticals,Inc. (NYSE: BRL ) today announced that its ... Merck & Co., Inc.,s Fosamax(R),(Alendronate Sodium) Tablets, 70 mg ... Administration (FDA)., The FDA approved the Company,s application ... associated with the,earliest to expire of the patents listed ...
Cached Biology Technology:Call for Entries - 2008 CURE Extraordinary Healer Award for Oncology Nursing 2Vermillion and Johns Hopkins Sign Collaborative Research and License Agreements to Develop Molecular Diagnostic Tests 2Barr Launches Generic Fosamax(R) Tablets, 70 mg 2Barr Launches Generic Fosamax(R) Tablets, 70 mg 3Barr Launches Generic Fosamax(R) Tablets, 70 mg 4
Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
fli-1...
Vesicle Associated Membrane Protein (VAMP 1/2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Biology Products: