Navigation Links
Gladstone scientists uncover mechanism for the major genetic risk factor of Alzheimer's disease
Date:10/13/2010

SAN FRANCISCO, CAOCT. 13, 2010 -- Alzheimer's disease (AD) is an extremely complicated disease. Several proteins seem to be involved in its cause and progression. For example, the lipid-transport protein apolipoprotein E4 (apoE4) is the major genetic risk factor for AD, and apoE4 carriers account for 65󈞼% of all Alzheimer's cases, but exactly how apoE4 contributes to the disease is unclear.

Scientists at the Gladstone Institutes of Neurological Disease (GIND) have provided new insights into how apoE4 might be involved. In a study published today online in the Journal of Neuroscience, researchers led by led by Yadong Huang, MD, PhD, reported that apoE4-dependent learning and memory deficits are caused by loss of a specific type of neuron in the learning and memory center of the brain.

"We found that mice that had been genetically engineered to produce human apoE4 lost a specific kind of cells and that loss of these cells correlated with the extent of learning and memory deficits," said Yaisa Andrews-Zwilling, PhD, postdoctoral fellow and lead author of the study.

Those key cells are called GABAergic interneurons in the hilus of the hippocampus, an area of the brain involved in learning and memory and affected by AD. GABA is an important neurotransmitter released from GABAergic interneurons. As one component of a delicately balanced system for regulating brain activity, GABA functions to inhibit brain activity. AD brains seem to have low levels of GABA.

"Importantly, apoE4 causes GABAergic interneuron loss and learning and memory deficits in the absence of Ab peptide accumulation, a widely suspected toxin in Alzheimer's disease," said Dr. Huang, senior author of the study. "This demonstrates clearly that apoE4 plays Ab-independent roles in Alzheimer's disease."

To try to overcome the decrease of GABAergic interneuron function, the Gladstone team treated the apoE4 mice with daily injections of pent
'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
2. Gladstone scientists reveal key enzyme in fat absorption
3. Gladstone scientists identify key factors in heart cell creation
4. Gladstones Shinya Yamanaka wins Lasker Award
5. Gladstone and Institute for Systems Biology collaborate on Huntingtons disease
6. Gladstones Shinya Yamanaka wins Kyoto prize
7. Gladstone scientists link hepatitis C virus infection to fat enzyme in liver cells
8. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
9. Scientists identify novel inhibitor of human microRNA
10. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
11. MU scientists go green with gold, distribute environmentally friendly nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... New York College, and one of the most prolific ... signals that are transmitted from Smartphones to third party ... Smartphones and has one of the earliest known patents ... its usage in the military, child care, elder care ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... microcontroller (MCU) and touch technology solutions, today launched the ... with the widest V cc range from ... accuracy and faster I 2 C bus communication speeds, ... EEPROM memory making them ideal for consumer, industrial, computer, ...
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that ... and at least seven more will participate in the upcoming ... Hotel in Washington D.C. , Dec. 2-4. ... support from the regulatory agencies in the United ... our effort to help advance the use of metrics in ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... As 17 countries and 30 organizations launch ... major environmental groups World Wildlife Fund, The ... governments, businesses, scientists, non-governmental organizations and individuals around ... coral reefs. The International Year of the Reef ...
... Stowers Institutes Proteomics Center has published a novel method ... of affinity purifications analyzed by mass spectrometry (APMS) to ... to associate with one another. The ... not only to the interactions within well-defined protein assemblies, ...
... as many scientists had given up the search, researchers ... cells with the capacity to generate new insulin-producing beta ... for humans, the newfound progenitor cells will represent an ... diabetes, the researchers report in the Jan. 25 issue ...
Cached Biology News:Environmental groups call for increased protection of coral reefs 2Stowers Proteomics Center devises method for assigning probabilities to human protein interactions 2Elusive pancreatic stem cells found in adult mice 2
(Date:12/24/2014)... Texas (PRWEB) December 23, 2014 ... methyl mercaptan such as its definition, classification, ... presents product specification, manufacturing process, and product ... technology and applications. The analysis also covers ... marketing channels, industry development trend and proposals. ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
(Date:12/22/2014)... MISSION VIEJO, Calif. , Dec. 22, 2014 /PRNewswire/ ... announce that CoPatient, an online medical bill review and ... newest offering in the FREE WellCard Savings discount health ... a medical bill that was more than they expected ... help members reduce health care costs, WellCard Savings is ...
Breaking Biology Technology:Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2
... Truman Medical Centers (TMC),became one of the first hospitals ... AS 128 slice CT scanner this week. The 128-slice,CT ... with minimal radiation exposure to the patient., "To ... country to have this,truly, first of its kind, state-of-the-art ...
... - Enerkem Inc., a leading second,generation biofuels ... new Vice-Presidents to its executive team: Mr. ... Marie-Helene Labrie,Vice-President, Government Affairs and Communications., ... executives to our management,team," said Mr. Vincent ...
... Aug. 28 deCODE genetics,(Nasdaq: DCGN ) today ... deCODE,CSO Jeffrey Gulcher,s presentation at Thomas Weisel Partners Healthcare,Conference ... PM ET / 5:30 PM GMT / 6:30,PM British ... Seasons Hotel,Boston, MA. The webcast can be accessed through ...
Cached Biology Technology:Truman Medical Centers Becomes One of the First Hospitals in the U.S. To Install the World's First Adaptive 128-slice CT Scanner 2Enerkem Expands Executive Management Team 2deCODE genetics to Webcast Presentation at Thomas Weisel Partners Healthcare Conference 2008 2