Navigation Links
Gladstone scientists reveal key enzyme in fat absorption

Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that a key enzyme involved in absorbing fat may also be a key to reducing it. The enzyme, acyl CoA: monoacylglycerol acyltransferase 2 or Mgat2 is found in the intestines and plays an important part in the uptake of dietary fat by catalyzing a critical step in making triglyceride, a kind of fat. Triglyceride accounts for nearly one-third of the fat eaten by people in developed countries.

Researchers in the laboratory of Robert V. Farese, Jr. MD, found that mice that were genetically modified to lack Mgat2 remain normal on a low-fat diet. However, when fed a high-fat diet that is similar to that eaten by many Americans, the mice do not get fat and do not develop other symptoms of obesity, such as glucose intolerance, hypercholesterolemia, and fatty livers. The mice eat the same number of calories as other mice, and the calories are fully absorbed. Results of their study were published in the current issue of the journal Nature Medicine.

"Because mice that lack this enzyme do not gain weight on a high-fat diet, it is an intriguing target for future interventions to prevent weight gain and the problems associated with that extra weight," said Dr. Farese.

The mechanism of action, the researchers identified was that the lack of Mgat2 may reduce the uptake of fat in the small intestine and delay its entry into the blood. This process may dissociate fat from carbohydrate absorption and insulin secretion and ultimately lower the amount of fat stored and used. How this happens is not clear. One possibility is that the absorbed fat is partitioned more to tissues where it is burned up.

"Differences in Mgat2 expression may contribute to the propensity of some people to gain weight from diets rich in fat," said Eric Yen, PhD, lead author of the study. "Our findings suggest that inhibiting this enzyme in the small intestine might be an effective way to treating metabolic diseases that result from excessive fat intake."


Contact: Valerie Tucker
Gladstone Institutes

Related biology news :

1. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
2. Gladstone scientists create Wikipathways to foster research collaboration
3. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
4. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
5. Geoscientists discuss sea level rise, extreme storm events and more
6. Scientists gather to protect global food security from return of devastating wheat fungus
7. Antibody key to treating variant CJD, scientists find
8. Undesirable evolution can be reversed in fish, Stony Brook University scientists show
9. Lincoln Park Zoo scientists awarded National Institutes of Health grant
10. JCVI program trains USDA scientists on eukaryotic genome analysis
11. Monash scientists debug superbug
Post Your Comments:
(Date:11/17/2015)... Paris from 17 th until 19 th ... from 17 th until 19 th November 2015.   ... the first combined scanner in the world which scans both ... two different scanners were required: one for passports and one ... same surface. This innovation is an ideal solution for electronic ...
(Date:11/16/2015)... Nov 16, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced expansion of its TDDI product ... touch controller and display driver integration (TDDI) solutions ... These new TDDI products add to the previously-announced ... TD4302 (WQHD resolution), and TD4322 (FHD resolution) solutions. ...
(Date:11/11/2015)... MINNETONKA, Minn. , Nov. 11, 2015   MedNet ... the entire spectrum of clinical research, is pleased to announce ... Partnerships in Clinical Trials (PCT) event, to be held ... will be able to view live demonstrations of ... platform, and learn how iMedNet has been able ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015  The Minnesota High Tech ... the 2015 Tekne Award in the Small and Growing ... the Minneapolis Convention Center, the ... a significant role in developing new technologies that positively ... the world. Clostridium difficile infection ( ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... provider, announces that its best selling system laboratory animal colony management software solution, ... today, without investing in on-site IT resources., , Many ...
(Date:12/1/2015)... SAN DIEGO , December 1, 2015 Dr. Harry Lander ... serving as Chief Science Officer and recruits ... Dr. Harry Lander , President of Regen, expands his role ... and recruits five distinguished scientists to ... of Regen, expands his role to include ...
(Date:11/30/2015)... ... November 30, 2015 , ... Global Stem Cells ... aesthetics professionals from Central America and abroad for the first Iberoamerican Convention on ... Feb. 17-19, 2016. Testart will present and discuss new trends in anti-aging stem ...
Breaking Biology Technology: