Navigation Links
Gladstone scientists link hepatitis C virus infection to fat enzyme in liver cells
Date:10/10/2010

SAN FRANCISCO, CAOctober 10, 2010Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have found that an enzyme associated with the storage of fat in the liver is required for the infectious activity of the hepatitis C virus (HCV). This discovery may offer a new strategy for treating the infection.

More than 160 million people are infected throughout the world, and no vaccine is available to prevent further spread of the disease. Current treatments are not effective against the most common strains in the US and Europe. The study, published in the journal Nature Medicine, shows that the enzyme DGAT1 is a key factor in HCV infection. With several potential DGAT1 inhibitors already in the drug-development pipeline, a treatment for HCV may be possible in the near future.

"Our results reveal a potential 'Achilles heel' for HCV infection," said Melanie Ott, MD, PhD, senior author on the study. "Several DGAT1 inhibitors are already in early clinical trials to treat obesity-associated diseases. They might also work against HCV."

At first glance, the HCV lifecycle is fairly simple. The virus enters the cell. One large protein is produced and cut into several smaller viral enzymes and proteins that build the virus. The RNA genome is copied, and the new RNAs and structural proteins are used to make new virus particles that are released into the blood stream for to infect more cells. These processes were thought to occur at specialized membranes inside the cell. However, recently it has been shown that fat droplets are critically involved.

Fat droplets, which store fat in cells, have become a hot new topic in biology. DGAT1 is one of the enzymes that help to form fat droplets. The Gladstone team, led by Eva Herker, PhD, discovered that HCV infection and viral particle production are severely impaired in liver cells that lack DGAT1 activity.

"DGAT enzymes produce the fat that is stored in the droplets t
'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstones Shinya Yamanaka wins Kyoto prize
2. Gladstone and Institute for Systems Biology collaborate on Huntingtons disease
3. Gladstones Shinya Yamanaka wins Lasker Award
4. Gladstone scientists identify key factors in heart cell creation
5. Gladstone scientists reveal key enzyme in fat absorption
6. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
7. Scientists watch cell-shape process for first time
8. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
9. Scientists trick bacteria with small molecules
10. DFG awards 4 young scientists 2010 Bernd Rendel Prize
11. Scripps Research scientists develop novel test that identifies river blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... is available in French . ... An international research project, led by the Research Institute ... reports that a new oral medication is showing significant ... amaurosis (LCA). Until now, this inherited retinal disease that ... blindness, has remained untreatable. The study is published today ...
(Date:7/11/2014)... The Mills Canyon fire started near the City of ... of local resources, the fire quickly grew to over ... cause of the fire is under investigation by the ... is working with existing local resources in developing fire ... Forest Service (USFS), Washington State Department of Natural Resources, ...
(Date:7/11/2014)... National Institute of Standards and Technology (NIST) need ... effectively, they often prove that necessity is truly ... recently for M. Lorna De Leoz and Stephen ... of glycomics. Glycomics is the study of the ... attached to proteins and lipids and influence cellular ...
Breaking Biology News(10 mins):MUHC researcher unveils novel treatment for a form of childhood blindness 2
... an adaptive strategy to help natural resource managers in ... to disturbance from major hurricanes. In an article published ... Scott Goodrick, and Ken Outcalt from the Forest Service ... the results of a case study based on the ...
... in the Academic Center for Dentistry Amsterdam have created ... osteoporosis by using ordinary dental x-rays. Professor Paul F. ... automated approach to detecting the disease during a three-year, ... and Malmö. They will present their findings today during ...
... at Johns Hopkins took advantage of a new technique ... all chemical changes nature makes by adding phosphate to ... team then added its list of these so-called phosphorylation ... publicly available database on the Web - PhosphoMotif Finder ...
Cached Biology News:How to manage forests in hurricane impact zones 2How to manage forests in hurricane impact zones 3Using dental X-rays to detect osteoporosis 2Speeding 'fingertip' discovery -- 20 years of protein info in 1 place 2
(Date:7/10/2014)... 10, 2014 Unraveling life’s mysteries can ... The Archer Family purchased a DNA test ... ended up with a lifetime of memories, sharing, and ... family members’ DNA genuinely brought the family closer together. ... deeper into genetic history and prior to taking the ...
(Date:7/10/2014)... 2014 OMICS Group’s 5th International conference ... August, 2014 at Double Tree by Hilton Beijing, China ... in Analytical & Bioanalytical research methods only to facilitate ... this occasion, Dr. Srinubabu Gedela, MD of OMICS Group ... a remarkable one in bringing a unique and international ...
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... ST. PETERSBURG, Russia , July 10, 2014 /PRNewswire/ ... the Russian Federation Dmitry Medvedev , presented ... a biopharmaceutical company BIOCAD . The Company is ... the scope of MabNext project BIOCAD develops a number ... of cancer and autoimmune diseases. The ceremony took place ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... , , ... Introduction , Formation of ... has therefore been the focus of many drug screening and cell signaling research ... of solid tumors, and is implicated in wound healing, retinopathy and macular degeneration. ...
... Varian, Inc. , Introduction ... (BPA) is a primary raw material used for the production of ... a degradation product of alkylphenol ethoxylate detergents used in household and ... additive in plastics that are used for food packaging and used ...
... Paul Gavin*, Mark Prescott*, Ph.D, Daren J. Fyfe#, Ph.D and Jeffrey J. ... * Department of Biochemistry and Molecular Biology, , Monash University, ... Victoria 3800, Australia , # Technical Assistance, , ... , Mulgrave, , Victoria ...
Cached Biology Technology:An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis 2An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis 3An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis 4Analysis of Phenolic Estrogen Mimics in River Water by Negative Ion Electrospray LC/MS/MS 2Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using , the Varian Cary Eclipse Fluorescence Spectrophotometer 2Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using , the Varian Cary Eclipse Fluorescence Spectrophotometer 3Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using , the Varian Cary Eclipse Fluorescence Spectrophotometer 4
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
IHC detection kit for PCNA in cells and tissues...
Incorporating the innovative InGaAs detection system the Cary 6000i is the worlds most advanced UV-Vis-NIR spectrophotometer delivering superior signal to noise performance and outstanding sensitivit...
ABI 432 Resins • Gln(Trt) Peptide Synthesis Column...
Biology Products: