Navigation Links
Gladstone scientists identify genes involved in embryonic heart development
Date:4/18/2011

SAN FRANCISCO April 16, 2011 Scientists at the Gladstone Institutes have identified networks of genes that play an important role in embryonic-heart development, advancing knowledge of how healthy hearts developand offering clues about how to combat a common birth defect known as congenital heart disease.

Congenital heart disease affects nearly 1 out of every 100 babies born worldwide and is the most common cause of death from a birth defect. In the disease, cells in the embryo often fail to get the right instructions while the heart is being formed. Many genes and proteins must be deployed at just the right time and in the right amounts for healthy heart formation to occur. Disruption of the correct dosage of proteins can lead to congenital heart defects.

One way cells control the amount of protein made from genes is through a recently discovered molecule called a microRNA. MicroRNAs are tiny strands of genetic material that do not encode the information to make enzymes and proteins, as most RNAs do. Instead, microRNAs inhibit other RNA molecules from producing protein. In recent years, scientists have discovered that each microRNA inhibits protein production from hundreds of RNAs, regulating almost every process in every cell of the body by fine-tuning the dosage of key proteins.

"MicroRNAs provide an extra layer of regulation that helps ensure that the correct amount of protein is made from a particular gene at the right time," said Isabelle King, a Gladstone scientist and an assistant professor of pediatrics at the University of California, San Francisco. Dr. King is the lead author on the study, the results of which were published in the April 17 issue of Developmental Cell. "In the fetal heart, subtle changes in gene dosage and timing can yield heart defects in children."

While microRNAs are powerful, it has been challenging to identify the hundred or more genes that each microRNA regulates. To overcome t
'/>"/>

Contact: Mara Brazer
mara@brazercommunications.com
415-305-6677
Gladstone Institutes
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gladstone scientists uncover mechanism for the major genetic risk factor of Alzheimers disease
2. Gladstone scientists link hepatitis C virus infection to fat enzyme in liver cells
3. Gladstones Shinya Yamanaka wins Kyoto prize
4. Gladstone and Institute for Systems Biology collaborate on Huntingtons disease
5. Gladstones Shinya Yamanaka wins Lasker Award
6. Gladstone scientists identify key factors in heart cell creation
7. Gladstone scientists reveal key enzyme in fat absorption
8. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
9. Scripps Research scientists identify mechanism of long-term memory
10. Scientists identify a surprising new source of cancer stem cells
11. Scripps Research scientists uncover new DNA role in modifying gene function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is a ... recognition system measures the overall facial feature of ... and the distance between eyes. Facial recognition is ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San Diego ... that provides the connective tissue that enhances care coordination ... to easily share client-level information; earned a second $1 ... to organizations serving seniors aging in community and; will ... on December 11 th 4-6p. CIE ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... JOLLA, CA-- It takes dozens of chemical reactions for a ... in every type of living organism. Cholesterol, for example, an ... isoprenoid chemical. The molecule that gives oranges their citrusy smell ... drug artemisinin. Now, researchers at the Salk Institute ...
... Biophysical Society is pleased to announce the speakers for ... in its fifth year and supported by supported by ... by young investigators at the interface of the physical ... Monday, February 17, 2014, in San Francisco, California as ...
... weaker as they age and then die, but that,s not the ... of aging at all. These are among the findings in ... this week. The study compares the aging patterns of humans ... about aging and what it should be like," said Pedro F. ...
Cached Biology News:Missing molecule in chemical production line discovered 2Missing molecule in chemical production line discovered 3Not all species age the same; humans may be outliers 2
(Date:12/24/2014)... Sigma-Aldrich Corporation (NASDAQ: SIAL ... the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) in ... 2014, thereby completing the U.S. HSR Act antitrust ... the Company by Merck KGaA, Darmstadt, Germany.  ... to closing the transaction, which remains subject to ...
(Date:12/24/2014)... and NEW YORK , ... from its open-label pilot study of mazindol in children ... Development and Therapy in December 2014 . ... mazindol in children with attention deficit/hyperactivity disorder" ( Konofal ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows ...
(Date:12/22/2014)... 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, with ... announced positive topline safety and tolerability results ... SYN-004, the Company,s investigational oral beta-lactamase enzyme ... (C. difficile) infection, antibiotic-associated diarrhea and ...
(Date:12/22/2014)... CHAPEL HILL, N.C. , Dec. 22, 2014 ... ALNE) today announced that it has signed a ... biotechnology company that has developed and patented a ... and medical diagnostics products that enable rapid on-site ... and alcohol use/abuse and health issues in an ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5ALNE Announces Intention To Acquire BioTechPharma 2
... Medical,Innovations, Inc. (Amex: IMA ), a leading provider ... a,dividend of $4.77 per share on its Series B ... paid in shares of Series B,stock in an amount ... divided by,(b) 97% of the average of the volume-weighted ...
... Sept. 15 Assay Designs and the Spinal,Muscular ... a,collaborative agreement for development of reagents and assays ... discovery and development,efforts for spinal muscular atrophy (SMA), ... toddlers. "Assay Designs is excited and proud to,have ...
... Sept. 15 Epeius Biotechnologies,Corporation today announced that ... has been highlighted in a recent NEWS article,published ... (JNCI, Sept. 9,2008). The article, authored by Vickie ... medicine that may succeed where small,molecules and proteins ...
Cached Biology Technology:Inverness Medical Innovations Declares Dividend on its Series B Convertible Perpetual Preferred Stock 2Assay Designs(TM), Inc. and the Spinal Muscular Atrophy Foundation Announce Collaboration To Accelerate the Discovery of New Therapeutics for Spinal Muscular Atrophy (SMA) 2Epeius Biotechnologies' Lead Product, Rexin-G for Metastatic Cancer, Aptly Highlighted by National Cancer Institute Journal 2
... Whether your projects are focused on sequencing, ... or in other areas of genomics and ... help you meet your research and manufacturing ... to take your project from beginning to ...
... Research Scale (gram quantities of IgY) , ... Prepare your Antigen), we segregate the appropriate number ... After 3 such eggs are collected (usually over ... injection series. This involves a total of four ...
... SOS Protein Solubility Service, We deliversoluble ... New SOS technology yields the best soluble ... applied on each clone submitted , Powerful ... ,The new protein Solubility Optimization Service (SOS) ...
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
Biology Products: