Navigation Links
Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
Date:12/6/2012

t Gladstone and is also a professor at the University of California, San Francisco, with which Gladstone is affiliated. "Here, we find that βOHBthe body's major source of energy during exercise or fastingblocks a class of enzymes that would otherwise promote oxidative stress, thus protecting cells from aging."

Oxidative stress occurs as cells use oxygen to produce energy, but this activity also releases other potentially toxic molecules, known as free radicals. As cells age, they become less effective in clearing these free radicalsleading to cell damage, oxidative stress and the effects of aging.

However, Dr. Verdin and his team found that βOHB might actually help delay this process. In a series of laboratory experimentsfirst in human cells in a dish and then in tissues taken from micethe team monitored the biochemical changes that occur when βOHB is administered during a chronic calorie-restricted diet. The researchers found that calorie restriction spurs βOHB production, which blocked the activity of a class of enzymes called histone deacetylases, or HDACs.

Normally HDACs keep a pair of genes, called Foxo3a and Mt2, switched off. But increased levels of βOHB block the HDACs from doing so, which by default activates the two genes. Once activated, these genes kick-start a process that helps cells resist oxidative stress. This discovery not only identifies a novel signaling role for βOHB, but it could also represent a way to slow the detrimental effects of aging in all cells of the body.

"This breakthrough also greatly advances our understanding of the underlying mechanism behind HDACs, which had already been known to be involved in aging and neurological disease," said Gladstone Investigator Katerina Akassoglou, PhD, an expert in neurological diseases and one of the paper's co-authors. "The findings could be relevant for a wide range of neurological conditions, such as Alzheimer's, Parkinson's, aut
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. ALS TDI and Gladstone Institutes collaborate to discover potential ALS treatments
2. Gladstone, Stanford scientists block toxic protein that plays key role in Lou Gehrigs disease
3. Gladstone scientists identify critical process in stem cell development
4. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
5. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
6. New test adds to scientists understanding of Earths history, resources
7. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
8. Salk scientists develop faster, safer method for producing stem cells
9. Kansas State University scientists named American Association for the Advancement of Science fellows
10. Liverpool scientists decipher genetic code of wheat
11. USDA scientists and cooperators sequence the wheat genome in breakthrough for global food security
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
(Date:4/17/2014)... way the immune system may fight cancers and viral ... cells to treat illness. , The research, in mice, ... "neighborhood police" specialized squads of defenders that patrol ... entire city, the body. , Scientists at Washington University ... the liver, skin and uterus each has dedicated immune ...
(Date:4/17/2014)... domestication derive from Charles Darwin, whose ideas in ... during the 19th century, a period when landowners ... is from Darwin that we inherit the ideas ... wild species and total human control over breeding ... this industrial setting has been applied too broadly ...
(Date:4/16/2014)... have identified a new syndrome called "osteosarcopenic obesity" that ... with obesity. , "It used to be the thinking ... would be because the bones were supporting more weight," ... at Florida State. "But, that,s only true to a ...
Breaking Biology News(10 mins):Some immune cells defend only 1 organ 2The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4Researchers: Obesity can amplify bone and muscle loss 2
... GAINESVILLE, Fla. Hit-and-run attacks by sharks can be ... by the unique chomp they put on their victims, ... expert. In a method analogous to analyzing human ... bites to the jaws and teeth of the powerful ...
... Charles Darwin it was an ,abominable mystery, and it is a ... did flowering plants evolve and how did they come to dominate ... reveals the evolutionary trigger which led to early flowering plants ... subsequent boom and abundance. The study, by Dr Tim Brodribb ...
... The first comprehensive review of the state of Antarctica,s ... is published this week (Tuesday 1 December) by the ... - Antarctic Climate Change and the Environment presents ... for future scientific research, and addresses the urgent questions ...
Cached Biology News:New forensic technique gives clues about sharks from bite damage 2New forensic technique gives clues about sharks from bite damage 3How did flowering plants evolve to dominate Earth? 2First comprehensive review of the state of Antarctica's climate 2
(Date:1/15/2014)... January 15, 2014 DTS Language Services, ... Online Web Portal for Life Science organizations who need document ... the subject matter of their documents in advance with a ... reduce time-to-delivery of translations, often a critical factor in clinical ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. – ... Warrington, Pa. , Details: The Hepatitis B Foundation, ... cure for hepatitis B and improving the quality of life ... on Friday, April 11 at Warrington Country Club in Warrington, ...
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... WESTBOROUGH, Mass. , Jan. 14, 2014  RXi ... on discovering, developing and commercializing innovative therapies addressing ... announced that it received the Notice of Allowance ... on its unique self-delivering RNAi compounds (sd-rxRNA®), for ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... be the nation,s next "Strontium Valley"? The University of Pittsburgh ... the National Science Foundation and the Nanoelectronics Research Initiative (NRI) ... kind of computer out of the lab and into the ... Levy, a professor of physics and astronomy in Pitt,s School ...
... 19, 2011 Reportlinker.com announces that a ... its catalogue: Established and ... http://www.reportlinker.com/p0618133/Established-and-Emerging-Biotech-Clusters.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biotechnology There has ... clusters of biotechnology companies and related organizations. ...
... HAYWARD, Calif., Sept. 19, 2011 OptiScan Biomedical ... systems for use in intensive care units (ICU), ... Glucose Monitoring System has received CE Mark certification ... Mark certifies that the OptiScanner has met all ...
Cached Biology Technology:Post-silicon computing 2Post-silicon computing 3Post-silicon computing 4Established and Emerging Biotech Clusters 2Established and Emerging Biotech Clusters 3Established and Emerging Biotech Clusters 4Established and Emerging Biotech Clusters 5Established and Emerging Biotech Clusters 6Established and Emerging Biotech Clusters 7Established and Emerging Biotech Clusters 8OptiScan Biomedical Receives CE Mark for OptiScanner Automatic Bedside Glucose Monitoring System 2OptiScan Biomedical Receives CE Mark for OptiScanner Automatic Bedside Glucose Monitoring System 3OptiScan Biomedical Receives CE Mark for OptiScanner Automatic Bedside Glucose Monitoring System 4
... is formulated for covering tissue sections and cell preparations immunohistochemically ... products. , ... Application: Vision ... AEC that require an aqueous mounting medium, or those that ...
... Target Retrieval Solution, High pH ... heat-induced target retrievel prior to immunohistochemical staining ... paraffin-embedded tissue sections mounted on glass slides. ... pH, 9.9, is especially effective. It should ...
Collected from calves that are 10 days old or less. Sterile, cell culture tested, US Origin...
... High pH, Concentrated x 10 This ... target retrievel prior to immunohistochemical staining procedures. ... tissue sections mounted on glass slides. For ... 9.9, is especially effective. It should be ...
Biology Products: