Navigation Links
Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
Date:12/6/2012

t Gladstone and is also a professor at the University of California, San Francisco, with which Gladstone is affiliated. "Here, we find that βOHBthe body's major source of energy during exercise or fastingblocks a class of enzymes that would otherwise promote oxidative stress, thus protecting cells from aging."

Oxidative stress occurs as cells use oxygen to produce energy, but this activity also releases other potentially toxic molecules, known as free radicals. As cells age, they become less effective in clearing these free radicalsleading to cell damage, oxidative stress and the effects of aging.

However, Dr. Verdin and his team found that βOHB might actually help delay this process. In a series of laboratory experimentsfirst in human cells in a dish and then in tissues taken from micethe team monitored the biochemical changes that occur when βOHB is administered during a chronic calorie-restricted diet. The researchers found that calorie restriction spurs βOHB production, which blocked the activity of a class of enzymes called histone deacetylases, or HDACs.

Normally HDACs keep a pair of genes, called Foxo3a and Mt2, switched off. But increased levels of βOHB block the HDACs from doing so, which by default activates the two genes. Once activated, these genes kick-start a process that helps cells resist oxidative stress. This discovery not only identifies a novel signaling role for βOHB, but it could also represent a way to slow the detrimental effects of aging in all cells of the body.

"This breakthrough also greatly advances our understanding of the underlying mechanism behind HDACs, which had already been known to be involved in aging and neurological disease," said Gladstone Investigator Katerina Akassoglou, PhD, an expert in neurological diseases and one of the paper's co-authors. "The findings could be relevant for a wide range of neurological conditions, such as Alzheimer's, Parkinson's, aut
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. ALS TDI and Gladstone Institutes collaborate to discover potential ALS treatments
2. Gladstone, Stanford scientists block toxic protein that plays key role in Lou Gehrigs disease
3. Gladstone scientists identify critical process in stem cell development
4. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
5. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
6. New test adds to scientists understanding of Earths history, resources
7. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
8. Salk scientists develop faster, safer method for producing stem cells
9. Kansas State University scientists named American Association for the Advancement of Science fellows
10. Liverpool scientists decipher genetic code of wheat
11. USDA scientists and cooperators sequence the wheat genome in breakthrough for global food security
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
(Date:9/12/2014)... origin and condition of extraction of type I collagen ... radii of their circular circular cross sections stay distributed ... for the most part of them. Jean Charvolin and ... the Paris-Sud University propose therefore that, once the growth ... factors, their lateral size be limited by internal physical ...
(Date:9/12/2014)... on the way to dealing with climate change: ... worth of previously unreachable oil and natural gas ... and benefits from "fracking," which requires blasting ... into underground rock formations, are the subject of ... government databases. The survey covers not only greenhouse ...
(Date:9/12/2014)... POINT ROBERTS, Washington , September 12, 2014 ... global news source covering leading sectors including biometrics and mobile ... 9 th launch of Apple Pay, its new payment ... Kephart , founder of the Secure Identity and Biometrics Association ... (NASDAQ: NXTD ) a company that is introducing ...
Breaking Biology News(10 mins):Conjecture on the lateral growth of Type I collagen fibrils 2Stanford-led study assesses the environmental costs and benefits of fracking 2Stanford-led study assesses the environmental costs and benefits of fracking 3Stanford-led study assesses the environmental costs and benefits of fracking 4Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 2Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 3Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 4Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 5
... and colleagues have identified a novel retroviral resistance gene, called ... virus, as well as HIV-1, in cell culture. The researchers ... specific laboratory rat cell line caused a significant block to ... and synthesize the viral DNA, but were excluded from entering ...
... Xcytrin, manufactured by Pharmacyclics, Inc.) works to thwart cancer ... according to a team of researchers led by Joseph ... at the Keck School of Medicine of the University ... increases in the amount of zinc available inside the ...
... conducted in monkeys at the Oregon National Primate Research ... of vitamin C may have potential to counteract some ... may benefit thousands of babies born to mothers who ... research is published in the current edition of the ...
Cached Biology News:USC researchers determine mechanism of action of chemotherapy drug 2OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies 2OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies 3
(Date:9/11/2014)... a one atom thick sheet of carbon, can be ... form of graphene that could have a significant impact ... paint, it could provide an ultra-strong, non-corrosive coating for ... oxide solutions can be used to paint various surfaces ... After a simple chemical treatment, the resulting coatings behave ...
(Date:9/11/2014)... 11, 2014 XBiotech announced today it has ... that the Company says will be used to dramatically ... is designed to fill, stopper and crimp vials, which ... the unit is said to contain an in-line feed ... a high level of quality compared to less sophisticated ...
(Date:9/11/2014)... 2014 The Registration Committee today ... now open for Pittcon 2015, the world’s largest ... event will be held March 8-12, 2015, at ... , The discounted registration fee of $175 ... 2/20/2015). This affordable price includes unlimited week-long access ...
(Date:9/11/2014)... (PRWEB) September 11, 2014 CollabRx, ... and IT systems that support clinical decision-making in ... Service that now supports the interpretation of copy ... a single, user-friendly report that contains clinically relevant ... toward cancer treatment planning and support of clinical ...
Breaking Biology Technology:Graphene paints a corrosion-free future 2Conferee Registration Opens for Pittcon 2015; Housing & Travel Open for Reservations 2CollabRx Launches Expansion of Its Genetic Variation Annotation Service to Support Copy Number Variation (CNV) Data 2CollabRx Launches Expansion of Its Genetic Variation Annotation Service to Support Copy Number Variation (CNV) Data 3
... -- ScinoPharm, an active,pharmaceutical ingredient (API) specialist, announced ... "Novel Crystal Forms of Irinotecan,Hydrochloride." The new patent ... processes for their preparation as well as,pharmaceutical compositions ... carcinoma of the colon or rectum using these ...
... Terumo Heart, Inc. is pleased to,announce the appointment ... (C.E.O.) and President, effective immediately. "With its innovative,mag-lev technology, ... in,the future treatment of heart failure. I am excited ... Pivotal trials in up to 40 clinical sites,and further ...
... 24 Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: IMDS) ... to announce the issuance of its,21st US Patent entitled ... of the Temporal Point Spread,Function of the Detected Light," ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ) , ...
Cached Biology Technology:ScinoPharm Granted US Patent for Novel Crystal Forms 2Terumo Heart Announces Appointment of William Pinon to Chief Executive Officer and President 2Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 2Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 3
... expression of an N-terminal FLAG® fusion and ... marker from bicistronic mRNA. Two genes ... for transcription of a single message from ... for protein-protein interaction studies, multi-subunit proteins, and ...
Mouse monoclonal antibody raised against a partial recombinant PRG4. NCBI Entrez Gene ID = PRG4...
Mouse monoclonal antibody raised against a partial recombinant FAAH. NCBI Entrez Gene ID = FAAH...
Mouse monoclonal antibody raised against a partial recombinant ZNF167. NCBI Entrez Gene ID = ZNF167...
Biology Products: