Navigation Links
Gladstone scientists create Wikipathways to foster research collaboration
Date:7/22/2008

- The rapid accumulation of biological data today is a significant challenge for researchers. That challenge is prompting some scientists to focus on new ways to better manage that data and to make it readily available. The laboratory of Bruce Conklin in the Gladstone Institute of Cardiovascular Disease has created a new collaboration tool, WikiPathways to focus on the use of biological pathways.

"Biological pathways connect genes and proteins in systems that contribute to normal physiology and disease," said Dr. Conklin. "They also organize our thinking about these processes."

Each pathway has to be built from information in multiple publications and databases. New pathway details are being uncovered every day, but the information needs to be organized in a workable system. The pathways also need to be amenable to computation, integration or data exchange. Pathway experts work all around the world, and most have little time to learn about complex databases that need their expertise.

To address these many challenges, the Conklin team chose to develop a new community-based model for pathway curation. In the collaborative spirit, this project was jointly conceived and executed in a partnership with Chris Evelo's lab in Maastricht Netherlands. The project is described in the current issue of PLoS Biology.

WikiPathways (http://www.wikipathways.org) is an open, collaborative platform for curating biological pathways. Building on the MediaWiki core that powers Wikipedia, they added a custom graphical pathway-editing tool and connections to major gene, protein and small molecule databases. This familiar web-based format makes it easy to participate. More importantly, it facilitates broad participation by the scientific community in peer review, editorial curation and maintenance of the pathway content.

"The wiki model as exemplified by Wikipedia, was an obvious place to
'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
2. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
3. Nature publishes new evidence about the deep biosphere written by biogeoscientists
4. ASBMB taps 8 scientists for top awards
5. When fish talk, scientists listen
6. Scientists demonstrate the sharpest measurement of ice crystals in clouds
7. Scientists demonstrate means of reducing Alzheimers-like plaques in fly brain
8. Scientists discover key patterns in the packaging of genes
9. Scripps research scientists reveal key structure from ebola virus
10. Scientists learn how food affects the brain
11. Scientists discover new reefs teeming with marine life in Brazil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Charan Ranganath of the UC Davis Center for ... National Security Science and Engineering Faculty Fellowship from ... million fellowship will support new work on learning ... UC Davis. , The new project aims to ... with activity in the cortex and hippocampus, brain ...
(Date:8/1/2014)... is tricky enough. Knowing what causes them at the ... of Iowa researchers have created the most detailed map ... long associated with blinding diseases, such as age-related macular ... in the choroid, which supplies blood and oxygen to ... differences in the abundance of proteins in different areas ...
(Date:8/1/2014)... 2014 The Journal of Nutrition Education and Behavior ... Educational Material (GEM) awards, which were presented at the ... "Nutrition Education Impact: Local to Global," in Milwaukee, Wisconsin, ... awards recognize the authors of the best article and ... by members of the JNEB Journal Committee and Board ...
Breaking Biology News(10 mins):A map for eye disease 2
... and Avalon Technology partner on new ... aviation-related ... Inc.,(OTC Bulletin Board: CTHH) ( http://www.catcherinc.com ), a leader ... Technology ( http://www.avalontechnology.com ), a leading,integrator of managed mobile ...
... resulting from higher CO2 could boost the amount ... new study looks at a poorly understood process ... Sayer, postdoctoral fellow at the Smithsonian Tropical Research ... University of Minnesotas Department of Ecology, Evolution and ...
... Boulder, CO, USA Two hundred years ago Lewis and ... deal of scientific research with its descriptions of territory acquired ... be disappointed by the absence of living megafauna, the area ... volume published by the Geological Society of America makes clear ...
Cached Biology News:CATCHER to be Deployed at Major U.S. Airline 2CATCHER to be Deployed at Major U.S. Airline 3CATCHER to be Deployed at Major U.S. Airline 4Complex carbon picture clearer 2
(Date:8/1/2014)... Applied DNA Sciences, Inc. (OTCQB: ... and product authentication solutions, will host a conference call ... third quarter results. The Quarterly Report on Form 10Q ... of the day on Monday August 11, 2014. ... conference call beginning at 9:00 A.M. Eastern Daylight Time ...
(Date:8/1/2014)... August 01, 2014 RURO, Inc., ... provider, today officially announces the opening of its ... Science Park, Baoshan District in Shanghai, PRC, RURO ... under the management of Mr. Shen Gang, the ... the past three years, RURO’s has installed FreezerPro-based ...
(Date:8/1/2014)... , Aug. 1, 2014 One of the ... of personalized medicine, which is the practice of using ... to a patient,s individual biology. Personalized diagnostics—laboratory analyses that ... role in the lab,s future. This fall, AACC ... the latest science in this exciting field and the ...
(Date:8/1/2014)... Research and Markets has announced the addition ... and Analysis Market 2014-2018" report to their offering. ... Single Nucleotide Polymorphism (SNP) genotyping is the screening and ... of various species. SNPs are commonly present in all ... analyze thousands of SNPs and has the potential for ...
Breaking Biology Technology:Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 2Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 3RURO Opens Office in Shanghai, China 2First-Ever AACC Virtual Conference to Focus on Personalized Diagnostics 2Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market 2014-2018 2
... COLUMBIA, Md., Dec. 14 A&G Pharmaceutical announced,today ... Initiative,has awarded A&G an $870,000 grant to conduct ... proprietary breast cancer biomarker,GP88, in blood and tissue ... could provide the basis for developing a blood ...
... Embla Systems, a leader in the field of,sleep ... of an,exclusive agreement with the Beth Israel Deaconess ... Pulmonary Coupling (CPC) technology,developed by Drs. Robert Thomas, ... CPC technology represents a breakthrough in how sleep ...
... New Mexico, December 13, 2007In collaboration with the ... international team of researchers has, for the first ... mysterious metallic puddles that facilitate the transition of ... one. , The research may lead to a ...
Cached Biology Technology:A&G Pharmaceutical Receives $870,000 Grant from Avon Foundation to Advance Innovative Blood Diagnostic Test for Early Detection of Breast Cancer 2A&G Pharmaceutical Receives $870,000 Grant from Avon Foundation to Advance Innovative Blood Diagnostic Test for Early Detection of Breast Cancer 3Embla Systems in Collaboration with Beth Israel Deaconess Medical Center to Develop Cardio-Pulmonary Coupling Technology 2Collaboration yields 'the right glasses' for observing mystery behavior in electrons 2Collaboration yields 'the right glasses' for observing mystery behavior in electrons 3
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
Anti-BAR Immunogen: Peptide of aa 3-21 from human Bar Available Date: 38226...
... the HECT protein, E6-AP and ... suggests that this E2 is ... of non-""N-end rule"" protein substrates ... proteins as well as the ...
Anti-Mouse D011.10 TCR, Biotin (Clone KJ1-26) (mouse IgG2a)...
Biology Products: