Navigation Links
Gladstone scientist finds new target for treating symptoms of Parkinson's disease
Date:9/7/2011

SAN FRANCISCO, CASeptember 8, 2011 A scientist at the Gladstone Institutes has identified how the lack of a brain chemical known as dopamine can rewire the interaction between two groups of brain cells and lead to symptoms of Parkinson's disease. This discovery offers new hope for treating those suffering from this devastating neurodegenerative disease.

In a paper being published online today in Neuron, Gladstone Investigator Anatol Kreitzer, PhD, identifies how the loss of dopamine alters the wiring of a small group of brain cells, kicking off a chain of events that eventually leads to difficulties controlling movementa hallmark of Parkinson's disease. More than a half-million people suffer from Parkinson's in the United States, including the boxer Muhammad Ali and the actor Michael J. Fox.

"The development of truly effective and well-tolerated therapies for Parkinson's has proven difficult," said Lennart Mucke, MD, who directs neurological disease research at the Gladstone Institutes, a leading and independent biomedical-research organization. Dr. Mucke is also a professor of neurology and neuroscience at the University of California, San Francisco (UCSF), with which Gladstone is affiliated. "Dr. Kreitzer's discovery sheds new light on the intricate processes that underlie motor problems in this disabling condition and will hopefully lead to the development of more effective medicines."

Normally, two types of brain cells called medium spiny neurons, or MSNs, work together to coordinate body movements, with one type acting like a gas pedal and the other as a brake. It has been thought that a reduction in dopamine, an important chemical in the brain, throws off the balance between the two opposing MSN forces, leading to problems with movement. But Dr. Kreitzer wondered if another factor might also be involved. To better understand the relationship between dopamine and MSNs in people with Parkinson's, Dr. Kreitzer artificially
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
2. Gladstone scientists reveal key enzyme in fat absorption
3. Gladstone scientists identify key factors in heart cell creation
4. Gladstones Shinya Yamanaka wins Lasker Award
5. Gladstone and Institute for Systems Biology collaborate on Huntingtons disease
6. Gladstones Shinya Yamanaka wins Kyoto prize
7. Gladstone scientists link hepatitis C virus infection to fat enzyme in liver cells
8. Gladstone scientists uncover mechanism for the major genetic risk factor of Alzheimers disease
9. Gladstone scientists identify genes involved in embryonic heart development
10. Gladstone to receive $5.6 million in federal funds to seek a cure for AIDS
11. Gladstone scientists offer new insight into the regulation of stem cells and cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... exists that cannabinoid receptor type 1 can ... influx, and reduce neurotransmitter release. However, some ... can increase extracellular Ca2+ influx and increase ... team, Tongji Hospital Affiliated to Tongji Medical ... China used whole cell voltage-clamp and calcium ...
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... it,s known that animals flourish in regions where the ... study set out to discover whether that same relationship ... Jurassic when dinosaurs roamed the Earth. "The assumption ... modern ecosystems," said paleontologist and lead author Timothy S. ...
... adolescents lose their protection from hepatitis B virus (HBV) ... infants. Results in the January 2013 issue of ... of the American Association for the Study of Liver ... HBeAg) and teens whose immune system fails to remember ...
... "Woodstock" song by Joni Mitchell, it turns out, was onto ... Chicago evolutionary biologist, Neil Shubin, PhD, makes that connection between ... "The Universe Within: Discovering the Common History of Rocks, Planets, ... Inner Fish." Where "Your Inner Fish" goes back ...
Cached Biology News:Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants 2Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants 3Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants 4Teens susceptible to hepatitis B infection despite vaccination as infants 2New book connects the human community to its cosmic roots 2New book connects the human community to its cosmic roots 3
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
(Date:7/10/2014)... Capital, a firm specializing in acquiring and managing food ... the Slim-Fast brand from Unilever. Unilever will retain a ... were not disclosed. Slim-Fast is a branded ... shakes, powders, bars and snacks to retail customers throughout ... United Kingdom and Ireland.  The ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... 9 Genstruct Inc., a,biotechnology company translating the complexity ... that Andrea Matthews,(age 25), manager of its Scientific Programs, ... Watch Under 30." "We are proud to have ... team," said Dr. Keith O. Elliston, president and CEO ...
... SciQuest will Save Time and Money, ... 9 The University,HealthSystem Consortium (UHC), an ... partners, and SciQuest, a provider of e-procurement,technology ... announced a partnership to provide organizations participating ...
... NATICK, Mass., Oct. 9 Boston Scientific,Corporation (NYSE: ... of its,CONFIENT(TM) implantable cardioverter defibrillator (ICD). This approval,represents ... treat sudden cardiac death (SCD). The CONFIENT ... is,designed to reduce unnecessary right ventricular pacing. This ...
Cached Biology Technology:Genstruct's Andrea Matthews Selected for Mass High Tech's 'People to Watch Under 30' 2University HealthSystem Consortium Chooses SciQuest to Optimize Medical Research Procurement 2University HealthSystem Consortium Chooses SciQuest to Optimize Medical Research Procurement 3Boston Scientific Announces European Approval of Next-Generation Implantable Defibrillator 2Boston Scientific Announces European Approval of Next-Generation Implantable Defibrillator 3
... receptors constitute the principal excitatory ... classes of glutamate receptors exist: ... Ionotropic glutamate receptors are oligomeric ... NMDA1-3, KAI-2) which comprise ligand-gated ...
... Block Moto Alpha unit with motorized heated lid ... that is useful for microarrays and chips. The ... blocks. The sealing force of the motorized lid ... to give repeatable results. This interchangeable Moto Alpha ...
Caspr2 Antigen: Fusion protein amino acids 96-1265 (extracellular domain) of human Caspr2 Accession Number: NP_054860...
... N,N- bis- (3-D-Gluconamidopropyl)deoxycholamide ... of CHAPS and CHAPSO. Has reduced electrostatic ... exchange chromatography on DEAE-cellulose. Aggregation number: 8-16. ... in H 2 O. Aggregation number 8 ...
Biology Products: