Navigation Links
Gladstone and Institute for Systems Biology collaborate on Huntington's disease
Date:6/15/2010

ology, we can make a tremendous step toward finding strategies for a cure.

The Gladstone team will provide DNA samples of HD patients and family members who are unaffected or at risk for HD, which will be sequenced by ISB in partnership with Complete Genomics of Mountain View, CA.

The Gladstone team is collecting DNA samples with help from collaborators including Dr. Vicki Wheelock and Terry Tempkin at the University of California, Davis, Andrea Zanko and Drs. Gail Kang, Michael Geschwind, and Bruce Miller at the University of California, San Francisco, and members of the Northern California Huntington's Disease Society of America. The sequencing project, which is also funded by ISB's Luxembourg program, is the largest complete human genome disease association study conducted to date.

Taube-Koret Center investigators at Gladstone are currently part of a large consortium funded by the National Institutes of Health that uses iPS cells to develop human neurons with HD characteristics. Fibroblasts are obtained from the skin cells of HD patients and converted first into iPS cells and then into neurons that may provide a more accurate platform for testing new therapies than currently available experimental models.

"One of the challenges of Huntington's and many other neurological diseases is that many potential therapies that show promise in animal models turn out to be ineffective in people," Finkbeiner said. "One of the promises of iPS technology is to be able to develop models from HD patients that can give us more detailed information about the disease and better predict how therapies could work in humans."

He pointed out that genomic information from the new collaboration could expand therapeutic opportunities not only for HD but also for other neurological diseases. "The hope is that the work we do here will lay the foundation for applying these techniques to more common but unfortunately more complex neurodegenerative diseases," Finkbein
'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gladstones Shinya Yamanaka wins Lasker Award
2. Gladstone scientists identify key factors in heart cell creation
3. Gladstone scientists reveal key enzyme in fat absorption
4. Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
5. Gladstone scientists create Wikipathways to foster research collaboration
6. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
7. Gladstones Shinya Yamanaka wins prestigious Shaw Prize
8. National Eye Institute hosts Translational Research and Vision Symposium
9. University of Washington institute to get as much as $100 million to study atmosphere, ocean
10. Norwegian Institute of Public Health receives $100,000 Grand Challenges Explorations grant
11. La Jolla Institute scientist leads team which discovers important new player in diabetes onset
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Law Enforcement Biometrics Market in North America ... About Biometrics Biometrics is a technology that ... their physical or behavioral patterns. It involves the ... as fingerprints, face recognition, DNA, palm print, hand ...
(Date:8/27/2014)... easier when it is related to ability that we ... a new melody more easily than learning how to ... Center for the Neural Basis of Cognition (CNBC)a joint ... Universityhave discovered a fundamental constraint in the brain that ... story in the Aug. 28, 2014, issue of ...
(Date:8/27/2014)... Europe based upon a proxy for impact have been ... data, approach to scientific research. , The researchers from ... the top 100 pathogens affecting humans and the top ... believe, will help governments across the continent plan for ... as a result of climate change, and for biosecurity. ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2
... a new protein that plays a critical role in enabling ... or stress, as well as in the progressive loss of ... Their findings, they said, suggest new approaches to prevent or ... in the U.S. The team reports its findings in the ...
... a number of Weizmann Institute scientists have addressed ... such as proteins, have adapted to function in ... from halophilic (salt-loving) microorganisms from the Dead Sea. ... proteins, researchers were able to explain how these ...
... it has discovered a new class of orally-effective, ... Biota has filed worldwide patents and selected a ... further preclinical development prior to human clinical trials. ... and already a billion-dollar market, with growing visibility ...
Cached Biology News:Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy 2Living with salt 2Biota makes major antiviral discovery 2
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com ... The Graphene Opportunity - A Rational View ... Graphene The New Nanotech? A similar amount ... of applications ranging from microelectronics to water treatment, ... announced the availability of the Graphene Opportunity Report, ...
(Date:8/27/2014)... JUNCTION, N.J. , Aug. 27, 2014 ... innovative drug delivery technologies, today announced that it has ... Jersey Business & Industry Association,s 2014 Awards for ... were selected by an independent panel of judges from ... company volunteers. Award winners will be honored at a ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Remcom announces ... with new features for the biomedical industry. ... enhanced Biological Thermal Sensor, exclusive to the Bio-Pro version ... version of XFdtd, developed to calculate the biological effects ... has been added to all versions to expand engineers’ ...
(Date:8/26/2014)... Bellingham, WA (PRWEB) August 26, 2014 ... visions for next-generation wearable technology, and inspiration for ... highlights at this year’s brighter, busier SPIE ... California, Convention Center. More than 4,400 international scientists, ... conferences, courses, an exhibition, and industry sessions sponsored ...
Breaking Biology Technology:The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... Company,s Cancer ... Therapy Product, PITTSBURGH, ... Kathy Blum as the company,s,new Chief Executive Officer. With extensive experience ... global experience with,start-ups and Fortune 500 organizations, Ms. Blum brings 27 ...
... Estate,Equities, Inc. (NYSE: ARE ) today will ... the world on a tour of Green and ... San Diego life,science cluster market. This unique BIO ... Biotechnology Industry Organization,s International,2008 Convention taking place in ...
... 16 Gen-Probe Incorporated,(Nasdaq: GPRO ) announced today ... Company 28th Annual Growth Stock on Wednesday, June 18, ... scheduled to be,webcast live and may be accessed through ... at http://www.gen-probe.com . The webcast will be,available for ...
Cached Biology Technology:Applied Computational Technologies Appoints a New CEO 2Alexandria Real Estate Equities, Inc. Features Green Buildings and Sustainable Operations Initiatives and Tour at 2008 BIO 2Alexandria Real Estate Equities, Inc. Features Green Buildings and Sustainable Operations Initiatives and Tour at 2008 BIO 3Alexandria Real Estate Equities, Inc. Features Green Buildings and Sustainable Operations Initiatives and Tour at 2008 BIO 4Gen-Probe to Webcast Presentation at the William Blair & Company 28th Annual Growth Stock Conference 2
... Round Well Plate Sterile ... wide range of 384-well ... high-throughput screening and research. ... assays and are suitable ...
... thermostable DNA polymerase purified from the Thermus ... developed by Kaledin (1,2,3) for the isolation ... from thermophilic bacteria. Amplification of DNA fragments ... with this enzyme. The enzyme has both ...
HLA-DRbeta (DA2)...
... 5 / 6 Cytokeratin 5 (58 ... type of cytokeratin expressed in basal, the ... stratified epithelia as well as transitional epithelia, ... mesothelioma. Cytokeratin 6 (56 kD) is also ...
Biology Products: