Navigation Links
'Gifted' natural vitamin E tocotrienol protects brain against stroke in 3 ways
Date:7/5/2011

or research in Ohio State's Department of Surgery and senior author of the study. "Here, a natural nutritional product is simultaneously acting on multiple targets to help prevent stroke-induced brain damage. That is a gifted molecule."

The research appears online and is scheduled for later print publication in the journal Stroke.

Over the past decade, Sen has led numerous studies on how the TCT form of vitamin E protects the brain against stroke damage in animal and cell models, and intends to eventually pursue tests of its potential to both prevent and treat strokes in humans. Approximately 795,000 Americans suffer new or recurrent strokes each year, and stroke is the third-leading cause of death in the United States, according to the American Stroke Association.

These latest research findings in mice follow a recent Food and Drug Administration certification of TCT as "Generally Recognized as Safe." The scientists conclude in the paper that even before clinical trials can take place, "TCT may be considered as a preventive nutritional countermeasure for people at high risk for stroke."

To determine the role of MRP1 in protecting brain cells, the researchers compared the effects of an induced stroke in two groups of mice: normal mice and animals that were genetically modified to be deficient in the MRP1 protein.

Both groups of mice showed comparably decreased blood flow in the area of the stroke, but the mice deficient in MRP1 had a larger volume of tissue death than did normal mice.

The mice with the protein deficiency also had a 1.6-fold higher level of a toxin that is cleared by MRP1. This toxin is called GSSG, or glutathione disulfide, and these researchers have previously shown that a failure to clear this toxin appears to trigger neuron death in the brain after stroke.

"The protein has the effect of dredging out the toxin," said Sen, who is also a deputy director of Ohio State's Davis Heart and
'/>"/>

Contact: Chandan Sen
chandan.sen@osumc.edu
614-247-7786
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Study: Preventive use of one form of natural vitamin E may reduce stroke damage
2. Natural-born consumers
3. Scientists a step closer to understanding natural antifreeze molecules
4. FSU dean wins prestigious E.O. Wilson Naturalist Award
5. News tips from the July issue of the American Naturalist
6. Evidence of a natural origin for banned drug that plumps up livestock
7. An all natural diet? Theres no such thing
8. Virtual natural environments and benefits to health
9. Silver cycle: New evidence for natural synthesis of silver nanoparticles
10. Natural protection against radiation
11. Tipsheet for the May issue of the American Naturalist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... (December 27, 2007) According to the Centers for Disease ... in the United States is obese and another third ... in energy balance, the finely modulated equilibrium between caloric ... determine how much food is consumed" Part of the ...
... release is available in Spanish . , ... include other forms of synaesthesia in which flavours are ... by time units, colours by music, etc. Experts on ... this phenomenon. The results of this research have been ...
... Hispanic women were found to have the highest prevalence of ... Americans having the lowest prevalence (0.5 percent), according to a ... Mutations in the tumor suppressor gene BRCA1 confer high risks ... 70 years has been estimated at 65 percent for breast ...
Cached Biology News:Overeating and obesity triggered by lack of BDNF 2Overeating and obesity triggered by lack of BDNF 31 person out of every 1,000 has synaesthesia, in which an individual can smell a sound 21 person out of every 1,000 has synaesthesia, in which an individual can smell a sound 31 person out of every 1,000 has synaesthesia, in which an individual can smell a sound 4Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer 2Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer 3
(Date:1/22/2015)... 21, 2015 Cambridge Semantics, the leading provider ... announced that 2014 was a record-breaking year across the board ... the Anzo Smart Data Platform and our Smart Data solutions, ... from diverse data which led to record growth for the ...
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
(Date:1/22/2015)... Madison, WI (PRWEB) January 22, 2015 Dr. ... at the 12th annual Scripps Natural Supplements Pre-Conference seminar on ... Supplements Conference is an annual continuing education conference for health ... 15th and included the topic of probiotics in health. Dr. ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 ... technologies such as the Bioruptor® and complete solutions ... system for chromatin immunoprecipitation, alleviating the need for ... and controls needed for ChIP of histones or ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... Milwaukee, Wis. - Metavante Corp. , the ... Ilsley Corp. , has announced the formation of a ... president, Fiserv, Inc. veteran Gary Kasik. , ... clients of Metavante customers to manage investments, certain income ...
... - The United States Senate, by a vote of ... ban on new federal funding for embryonic stem cell research, ... fell short of the 67 votes needed to override a veto, ... ,The bill, known as the Stem Cell Research Enhancement Act ...
... - The legal challenge to stem cell patents held ... the war of words between two states -Wisconsin and California ... most recent exchange came after the Public Patent Foundation ... and Consumer Rights , filed a formal request with the ...
Cached Biology Technology:Senate approves bill to expand stem cell funding 2Request to re-examine WARF stem cell patents escalates war of words 2Request to re-examine WARF stem cell patents escalates war of words 3
Rabbit polyclonal to Lck (phospho Y192) ( Abpromise for all tested applications). entrezGeneID: 3932 SwissProtID: P06239...
Rabbit polyclonal to SUR1 ( Abpromise for all tested applications). Antigen: Synthetic peptide Entrez Gene ID: 6833 Swiss Protein ID: Q09428...
... Vasopressin The antibody blocks with ... found in the paraventricular and supraoptic ... the hypothalmus in rat brain of ... Immunogen: Arginine Vasopression Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 ...
Pronase Reagent...
Biology Products: