Navigation Links
Giant raft of data to help us understand disease
Date:6/28/2012

Scientists at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have used a new method to assemble a massive catalogue of data on proteins. This gives them unprecedented insight into a process called protein phosphorylation. The research was recently published in the scientific journal Nature Communications.

Postdoc Alicia Lundby, from the Novo Nordisk Foundation Center for Protein Research, says: "Phosphorylation changes are really important to our understanding of cancer and other diseases. Although the study of phosphorylation goes back decades, up until now we hadn't been able to measure overall phosphorylation changes in tissue samples. Understanding these phosphorylation changes brings us a step closer to unravelling the mechanisms of disease."

Unravelling the mechanisms of disease

Phosphorylation happens when a phosphate group is added to a protein. Phosphorylation is like a switch that activates proteins, altering their function and changing cell signalling pathways. These signalling pathways are like cellular control panels. Deregulated cell signalling, when the control panel malfunctions, is a common hallmark of disease.

In the treatment of cancer, for example, there is great variation in how well the patients respond to different treatments. Most likely as a result of differences in the signalling pathways. The method developed by the team has the potential to make it possible to screen patient tissue samples to determine the best course of treatment for the individual.

An unprecedented resource

The team of scientists used high-resolution tandem mass spectrometry to generate the catalog of phosphorylated proteins. This research has never been attempted before on this scale 31,480 phosphorylation sites from 7,280 proteins in 14 different tissue types. From a scientific perspective, it offers an unprecedented resource that is available to b
'/>"/>

Contact: Alicia Lundby
alicia.lundby@cpr.ku.dk
(45) 60-75-80-95
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ancient giant turtle fossil revealed
2. Big-mouthed babies drove the evolution of giant island snakes
3. First satellite tag study for manta rays reveals habits and hidden journeys of ocean giants
4. Jurassic pain: Giant flea-like insects plagued dinosaurs 165 million years ago
5. Giant squids giant eyes: The better to see hungry whales with
6. Discovery increases understanding how bacteria spread: U of A study
7. Understanding faults and volcanics, plus life inside a rock
8. Evaluation of microscopy techniques may help scientists to better understand ancient plants
9. New understanding of terrestrial formation has significant and far reaching future implications
10. A trained palate: Understanding complexities of taste, smell could lead to improved diet
11. Zebrafish could hold the key to understanding psychiatric disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... fragments called "jumping genes" that insert themselves into DNA ... phenomenon can result in age-related diseases such as cancer. ... that the "jumping genes" in mice become active as ... them in check in order to take on another ... Nature Communications , Professor of Biology Vera Gorbunova ...
(Date:9/22/2014)... new American Cancer Society study suggests that participants ... known as the food stamp program, had lower ... The authors say the findings emphasize the need ... quality of SNAP participants. , The SNAP program ... the resources to obtain a nutritionally adequate diet. ...
(Date:9/22/2014)... researchers are studying a potential new treatment that reverses ... which scars develop in the lungs and severely hamper ... which is delivered to lung tissue intravenously. In mouse ... fibrosis after several days. , The findings were ... Medicine . , "The mimic, when injected into the ...
Breaking Biology News(10 mins):A multi-function protein is key to stopping genomic parasites from 'jumping' 2Federal food program puts food on the table, but dietary quality could be improved 2Reversing the effects of pulmonary fibrosis 2
... the Upper Paraguay River and its tributaries, is the largest ... of organisms and it is an ark for large populations ... Pantanal fulfills a large range of ecosystem services that are ... seasonal floodplain system, plants, animals, and local human populations show ...
... cover all from the historical aspects of the beaver ... the development of reintroduced or recovering populations, consequences of ... beavers, relationship with animal and plant communities on land ... the high degree to which the beaver is able ...
... (Nicols Prez Hidalgo and M. Pilar Mier Durante) have ... Matsumura ) in Madrid, Spain from a photography displayed ... ) (ngel Umaran). The results have been published recently ... are available for free download. "This discovery is ...
Cached Biology News:
(Date:9/23/2014)... (PRWEB) September 23, 2014 Marktech Optoelectronics ... deep ultra violet emitters in the 280 nm wavelength ... UV emitters which range from 280nm to 405nm. These ... water sanitation as well as curing. Mark Campito, Marktech’s ... of special interest to manufacturers is that we offer ...
(Date:9/23/2014)... September 23, 2014 The Minnesota ... developer of cellular modems , platforms and ... the Startup category for the 2014 Tekne Awards. ... at the Minneapolis Convention Center on Thursday, November ... individuals who have shown superior technology innovation and ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Pearl's Premium ... breakthrough in drought tolerant grass seed this week with ... seed. The announcement coincides with the fact that it ... Spring as many believe. , As of the ... and favorable reviews by industry experts and the media ...
(Date:9/22/2014)... by researchers at the USC Viterbi School of ... 3-D microfluidic system quickly and cheaply by simply ... Microfluidic systems are used in many fields including ... volumes of fluids for use in applications such ... diagnostic testing, and synthetic chemistry. Traditionally, microfluidic devices ...
Breaking Biology Technology:Marktech Introduces its New Line of Deep UV Emitters 2NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 5
... , Chemosaturation Demonstrates Clinically Meaningful Tumor ... Delcath Systems, Inc. (NASDAQ: DCTH ... tumor (mNET) cohort of the Company,s recently completed Phase ... and Interventional Radiological Society of Europe (CIRSE) congress ...
... N.Y. A new system to be installed ... enable exciting new research possibilities across the nation ... modeling and simulation, data science, high-performance computing, and ... million grant from the National Science Foundation (NSF) ...
... All ABC Members and Members of the Herb and ... that I inform you of the passing of our ... Saturday evening, September 10, per the tribute we have ... Director, American Botanical Council, Editor, HerbalGram & HerbClip ...
Cached Biology Technology:Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 2Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 3Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 4Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 5New supercomputer to boost Rensselaer leadership in high-performance computing 2New supercomputer to boost Rensselaer leadership in high-performance computing 3New supercomputer to boost Rensselaer leadership in high-performance computing 4Norman R. Farnsworth, Renowned Medicinal Plant Researcher, Dies at 81 2Norman R. Farnsworth, Renowned Medicinal Plant Researcher, Dies at 81 3Norman R. Farnsworth, Renowned Medicinal Plant Researcher, Dies at 81 4Norman R. Farnsworth, Renowned Medicinal Plant Researcher, Dies at 81 5Norman R. Farnsworth, Renowned Medicinal Plant Researcher, Dies at 81 6Norman R. Farnsworth, Renowned Medicinal Plant Researcher, Dies at 81 7
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
...
... versatile enclosures are designed ... or other process gas ... environment. HEPA filtration, heating/cooling, ... modules also available, along ...
... Staccato Series of systems provide fast and ... , genomics, proteomics and drug development laboratories. ... configurations; Mini Workstation Series, Application Series and ... Station is a remarkably compact system for ...
Biology Products: