Navigation Links
Getting organized: Berkeley Lab study shows how breast cell communities organize into breast tissue
Date:3/11/2011

ruption of these adherens junction proteins or the actomyosin network that supports them either prevented the formation of the bi-layer, or caused a loss of pre-formed bi-layers. This is the first reported evidence that the two principle lineages of adult human mammary gland possess intrinsic and reversible characteristics that guide their organization into a bi-layer."

Throughout a person's life, the various tissues in his or her body will be replenished and repaired by drawing upon a reservoir of adult stem cells. As new cells replace old ones or are used to construct new tissue, the architecture of that specific tissue must be maintained. Otherwise, cancer or other diseases can arise. This process requires that lineage-specific progenitor cells or their differentiated progeny be able to reach their ultimate destination within the tissue. This task is particularly daunting for breast cell lineages because the mammary gland undergoes cyclical changes in its architectural structure, showing as much as a 10-fold expansion in preparation for lactation followed by return to normal size. During these cycles, the precise bi-layered branching organization throughout the gland, in which a layer of secretory luminal epithelial cells (LEPs) is surrounded by a layer of contractile myoepithelial cells (MEPs), must be maintained.

"We hypothesized that mammary epithelial cells possess lineage-specific intrinsic abilities to self-organize into domains of lineage specificity, which would help explain how, for instance, the mammary stem cell-enriched zone in the ducts is maintained separately from the rank-and-file LEPs and MEPs, and how LEPs and MEPs form and maintain bi-layers," LaBarge says. "The phenomenon of self-organization has not been well studied in humans, perhaps because of the challenges of working with primary materials and a paucity of tractable culture systems for maintaining cell types from normal adult tissues."

Initially, LaBarg
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Getting rid of cattle fever ticks
2. Getting a tail up on conservation?
3. Warning system inadequate to prevent swimmers from getting sick at inland lakes
4. Getting a step ahead of pathogens
5. Getting young scientists into the science teacher pipeline
6. Solid oxide fuel cells getting closer to the market
7. Research is getting closer to understanding critical nucleus in haze formation, prof says
8. Preventing cells from getting the kinks out of DNA
9. Forest epidemic is unprecedented phenomenon, still getting worse
10. Getting turned on
11. Most patients gain weight after getting a new knee, UD study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Getting organized: Berkeley Lab study shows how breast cell communities organize into breast tissue
(Date:7/11/2014)... explored two different ways that allow unprecedented experimental ... formation of oxygen molecules in photosynthesis. The two ... Nature Communications . , "The new knowledge ... water oxidation, which are key components for building ... solar energy in fuels like hydrogen, ethanol or ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/10/2014)... Santa Fe, Albuquerque, and other major cities in New ... with treated municipal wastewater rather than precious potable water ... than 40% of all golf courses receive treated effluent. ... , Additionally, golf courses and homeowners alike fertilize ... in fertilizer is nitrate. A New Mexico State University ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... of grapes (Vitis vinifera) chiefly to make wine, is an ... from the Neolithic and Early Bronze Ages. We have a ... grape harvest leading to the concept of terroir (the range ... nature of the grapes themselves has been less well understood ...
... CRUZ, CA-- No human can survive longer than a few ... gulps of air. Our brains need a constant supply of ... seals, animals that dive and hunt under the Antarctic sea ... minutes, and remain active and mentally alert the whole time. ...
... HOUSTON (Dec. 18, 2007)Researchers at The University of ... between genes regulating glucose metabolism and spina bifida. The ... from parents and their children with that birth defect. ... dozen genes that take part in glucose metabolism to ...
Cached Biology News:Plant geneticists find veritas in vino 2Plant geneticists find veritas in vino 3Why diving marine mammals resist brain damage from low oxygen 2Why diving marine mammals resist brain damage from low oxygen 3Why diving marine mammals resist brain damage from low oxygen 4UT-Houston's Northrup and colleagues uncover genetic link to spina bifida 2
(Date:7/10/2014)... WASHINGTON D.C., April 15, 2014 -- According to ... danger to nuclear security comes from terrorists acquiring ... (HEU) to construct a crude nuclear explosive device. ... illicit nuclear trafficking have involved gram-level quantities, which ... methods. , According to a new study appearing ...
(Date:7/10/2014)... has been extremely challenging because there are many genetic ... cause disease. Now investigators reporting in the July 3rd ... Cell describe a strategy that may help reveal ... factors or environmental exposures to affect the development of ... that may predispose individuals to schizophrenia. , The ...
(Date:7/10/2014)... theatergoers have shelled out for crude 3-D glasses, ... viewing experience. These basic devices, used to trick ... may soon be rendered obsolete with the introduction ... University researchers. , TAU doctoral students Yuval Yifat, ... efficient holography based on nanoantennas that could be ...
(Date:1/15/2014)... "The interface is the device," Nobel laureate Herbert ... to be found at the junctures where layers ... of nanotechnology, the interfaces between layers of metal ... such high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3A deeper look at interfaces 2
... 26 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: OXBO) ... sites in Israel for the planned Phase II dose ... Oxycyte is the company,s perfluorocarbon (PFC) therapeutic oxygen carrier. ... planned for Switzerland."Israeli physicians are excited to be able ...
... 26 Cornerstone Therapeutics Inc. (Nasdaq: CRTX ), a specialty ... the respiratory market, today reported financial results for the year ended December ... Full-Year 2008 Net Revenues more than doubled ... , , , ...
... LASIK Surgeons directory service and website at www.TrustedLASIKSurgeons.com ... seeking to improve their vision and find a highly ... attaining 20-20 vision. What sets the Trusted LASIK ... that only those who are among the best in ...
Cached Biology Technology:Oxygen Biotherapeutics, Inc. Adds Oxycyte TBI Clinical Trial Sites in Israel 2Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 2Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 3Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 4Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 5Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 6Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 7Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 8Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 9Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 10Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 11Cornerstone Therapeutics Reports Year Ended December 31, 2008 Financial Results 12Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 2Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 3Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 4Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 5Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 6Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 7Trusted LASIK Surgeons Welcomes LASIK Expert William Mathers, M.D. of the Casey Vision Correction Center in Portland, Oregon, to Its LASIK Directory 8
...
MOUSE ANTI BOVINE WC1:FITC Immunogen: Bovine lymphocytes...
... kit contains the basic components required for ... natural and recombinant Feline IL-10 in cell ... sufficient materials to run ELISAs on approximately ... conditions are met: The assay is ...
Request Info...
Biology Products: