Navigation Links
Getting down to cancer basics
Date:3/29/2009

pproaches. These results indicate that cancer genes are not restricted to 'classical' roles of survival and cell proliferation, but can affect a variety of other cellular mechanisms," explains Professor Victor Velculescu, Associate Professor of Oncology and Director of Cancer Genetics from the Ludwig Center at Johns Hopkins and co-Director of Cancer Biology, at Johns Hopkins Kimmel Cancer Center. "UTX wouldn't have been found without this high-throughput type of study and indicates the type of novel findings we might expect from the International Cancer Genome Consortium."

The International Cancer Genome Consortium (ICGC) seeks to catalogue genetic abnormalities in 50 different tumour types. The possibility of uncovering new regulatory genes - like UTX - along with continued efforts to catalog cancer genes, will boost researchers' attempts to comprehensively describe different cancers which will to lead to expanding opportunities to reduce the global cancer burden.

The team showed that the biology of the mutation fitted their prediction. Cells that lacked a functional UTX gene showed notable slowing of growth when a copy of normal UTX was reintroduced. As well, substantial changes in gene transcription were noted. Genes with the most significant changes in expression were highly enriched in those most susceptible to control by UTX mediated histone modification.

The work identifies a new class of cancer genes that researchers can now pursue. These are genes that occupy the central control position of gene activity and act to keep cells from turning cancerous. When such 'tumor suppressor genes' are inactivated, other genes can run riot.

The consequence of mutation in UTX is to bring about changes in activity of other genes through epigenetic changes - their activity is changed by modification, not of their DNA code, but of their associated proteins and chemical tags.

"This is a genetic change with consequences at the leve
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The sea ice is getting thinner
2. Getting wise to the influenza virus tricks
3. Getting better with a little help from our micro friends
4. Getting to the root of the matter
5. Getting warmer? Prehistoric climate can help forecast future changes
6. Many middle-aged and older Americans not getting adequate nutrition
7. Getting into hot water
8. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. Protein chatter linked to cancer activation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/9/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), a ... it will report financial results for the third quarter ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-438-5524 ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... the shrimp fisherman Uwe Abken has had little interest in ... the East Friesian town of Neuharlingersiel has been taking a ... recording which North Sea exotics and rare migratory fish get ... from the German Alfred Wegener Institute for Polar and Marine ...
... Life deep in the seabed proceeds very slowly. But ... an important role in the global storage of organic carbon ... from Aarhus University (Denmark) and the University of Rhode Island ... deep down in the seabed. Their findings were ...
... have "compelling evidence" that the Deepwater Horizon oil spill ... in the journal Proceedings of the National Academy ... oil spill on a deep-water coral community in the ... vehicles, including the submarine Alvin, to investigate the corals ...
Cached Biology News:EU project: Searching for exotics in the shrimp nets 2EU project: Searching for exotics in the shrimp nets 3Oceanographers develop method for measuring the pace of life in deep sediments 2Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean 2Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean 3Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean 4
(Date:5/21/2015)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... commercializes proprietary technologies and products for advanced microarray diagnostics, ... second fiscal quarter ended March 31, 2015. ... business with our existing customers and to develop new ... of SQI. "The delivery of a fully automated sqidlite™ ...
(Date:5/21/2015)... May 21, 2015 Specialty Pharmacy ... and been admitted to BPA Worldwide as a ... will track audience data for Specialty Pharmacy Times ... , “By becoming a member of BPA Worldwide, ... providing our clients with the most reliable, unequaled ...
(Date:5/21/2015)... , May 21, 2015  Prima Biomed Ltd. (NASDAQ: ... is striving to become a leader in the development ... announced that the final CVac data from the Phase ... clear trend for a clinically meaningful improvement in Overall ... remission patients. In the group of second ...
(Date:5/21/2015)... , May 21, 2015  The EveryLife ... Hatch (R-UT) and Amy Klobuchar ... Now Accelerating Cures & Treatments, or OPEN ACT. ... disease patient advocacy organizations, this bipartisan legislation promises ... affordable medicines to rare disease patients by incentivizing ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Specialty Pharmacy Times Joins BPA Worldwide 2Correction Continues after Big Move - BrokerBank Securities, Inc. 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2
... CRGN ), a clinical-stage biopharmaceutical company focused ... dated January 28,2008, from The NASDAQ Stock Market, ... days, the closing bid price of CuraGen,s,common stock ... share required for,continued listing on the NASDAQ Global ...
... for significant public health hazard of CO, poisoning and advises ... to meet ... of care, IRVINE, Calif., Jan. 29 Masimo (Nasdaq:,MASI), ... pulse oximetry, today announced that the National Association of,Emergency Medical ...
... 2007 distributions as,follows:, Security Description: Common Stock ... CUSIP: 09063H107 ... Total Allocable Record ... Date Per Share 2007 ...
Cached Biology Technology:CuraGen Corporation Receives Notification from NASDAQ 2CuraGen Corporation Receives Notification from NASDAQ 3National Association of Emergency Medical Technicians (NAEMT) Supports Prehospital Screening for Carbon Monoxide in the Blood 2National Association of Emergency Medical Technicians (NAEMT) Supports Prehospital Screening for Carbon Monoxide in the Blood 3National Association of Emergency Medical Technicians (NAEMT) Supports Prehospital Screening for Carbon Monoxide in the Blood 4National Association of Emergency Medical Technicians (NAEMT) Supports Prehospital Screening for Carbon Monoxide in the Blood 5BioMed Realty Trust Announces Tax Treatment of 2007 Distributions 2BioMed Realty Trust Announces Tax Treatment of 2007 Distributions 3
Rabbit polyclonal to Kallikrein 1 ( Abpromise for all tested applications). Antigen: Full length native kallikrein from tissue (Human) Entrez Gene ID: 3816 Swiss Protein ID: P06870...
Purified anti-mouse Tim-1...
EDG-1CT (endothelial cell differentiation gene-1, C terminal)...
Mouse Anti-human CD11b/Mac-1alpha, clone LM2/1, Monoclonal Antibody...
Biology Products: