Navigation Links
Getting down to cancer basics
Date:3/29/2009

Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes. The new example - a gene on the X chromosome called UTX - is found in 10% of cases of multiple myeloma and 8% of esophageal cancers.

UTX plays a role in overall regulation of the activity of many genes and it is possible that other genes with similar roles will also be found to be involved in different tumor types. This is the first example of mutations in a gene of this functional class. The finding arose from a study of mutations in 4000 genes in kidney cancer.

"UTX is an important component of the transcriptional control machinery - it influences some of the most fundamental mechanisms controlling gene activity in our cells," explains Dr Andy Futreal, co-leader of the Cancer Genome Project at the Wellcome Trust Sanger Institute. "Unlike many cancer genes, UTX does not appear to be directly involved in cell division or cell death but in basic gene regulation and shows the depths to which cancers will plumb in order to get themselves ready to go."

The normal UTX protein modifies part of the structure holding DNA together in our cells. The composite DNAprotein structure, called chromatin, is not simply a scaffold, but plays an active role in controlling gene activity. The UTX protein alters a key organising subunit component of chromatin, called a histone. The protein is likely to be involved in both turning genes on and off, making it a key regulator of the yin-yang of gene control.

In the massive DNA sequencing study, the team found rare mutations of the UTX gene in clear cell renal cancer - a type of kidney cancer. When they expanded the search they found mutations in many cancer types - including one in ten multiple myeloma and one in twelve esophageal cancer cases.

"This work shows that mutations in genes with different functions can be found in human cancer through systematic a
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The sea ice is getting thinner
2. Getting wise to the influenza virus tricks
3. Getting better with a little help from our micro friends
4. Getting to the root of the matter
5. Getting warmer? Prehistoric climate can help forecast future changes
6. Many middle-aged and older Americans not getting adequate nutrition
7. Getting into hot water
8. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. Protein chatter linked to cancer activation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet, ... March 30 th . The new ... York markets. Gino Pereira ... new ad campaign following the recent initial shipment of Wocket ...
(Date:3/20/2015)... OXFORD, Conn. , March 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... Wocket® smart wallet is one of the products featured ... today, March 20th at 11:00 PM EST on the ... travels to Las Vegas , site ...
(Date:3/18/2015)... March 18, 2015 As mobile payments ... revolutionary smart wallets and apps continue to be introduced into ... in the mobile payment industry in focus today are:  NXT-ID, ... (NYSE: BABA ), Apple Inc. (NASDAQ: ... Facebook Inc. (NASDAQ: FB ) NXT-ID, ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... As a result of field work by associate professor James ... of the Ryukyus in Okinawa, Japan has found two ... in unexpected locations. The species belong to the genus ... species in the Indian Ocean. Surprisingly, the new species were ...
... articles about the Deepwater Horizon oil spill provides ... science used in the unprecedented response effort by ... behind-the-scenes look at the extensive scientific and engineering ... outside the governmentassembled to respond to the disaster. ...
... Calif., Nov. 29, 2012  Medbox, Inc. (OTC Markets: MDBX) ... their unique and patented biometric medical marijuana dispensing system ... recent days. The Medbox system provides patients with safe, ... products in states that have legal medical marijuana programs. ...
Cached Biology News:An ocean away: 2 new encrusting anemones found in unexpected locations 2Research, response for future oil spills: Lessons learned from Deepwater Horizon 2Research, response for future oil spills: Lessons learned from Deepwater Horizon 3Research, response for future oil spills: Lessons learned from Deepwater Horizon 4Medbox, Inc. Featured in Multiple Media Stories in Massachusetts and California 2Medbox, Inc. Featured in Multiple Media Stories in Massachusetts and California 3
(Date:4/21/2015)... , April 21, 2015 Merrimack Pharmaceuticals, ... from a multi-arm Phase 1 study of MM-141, a ... presented in an oral session by Dr. Mansoor ... Cancer Research Annual Meeting in Philadelphia, PA. ... of MM-141 as a monotherapy and in combination with ...
(Date:4/21/2015)... , April 21, 2015  Tute Genomics, a leading ... of Josh Forsythe as VP of Marketing. Mr. ... witnessed a significant expansion in its commercial operations over the ... " Josh Forsythe is a tremendous addition ... MD MBA, CEO of Tute Genomics. "Josh,s vast experience commercializing ...
(Date:4/21/2015)... New York (PRWEB) April 21, 2015 ... and Fertility Authority, LLC, announced that it has secured ... Byers (KPCB), TPG Biotech, SR One and Merck Serono ... efforts to provide patients the best fertility outcomes by ... is the largest online marketplace for families seeking fertility ...
(Date:4/20/2015)... April 20, 2015 Stent retriever thrombectomy, ... vessels in the brain reduced disability after stroke, ... Jovin, MD, President of the Society of Vascular ... is a giant step forward that will change ... stroke patients," said Jovin, who is associate professor ...
Breaking Biology Technology:First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 2First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 3First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 4First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 5Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4Announcing Progyny: Combining Best-in-Class Clinical Solutions with Consumer Expertise 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 2SVIN President Tudor Jovin, MD, Co-Leads Groundbreaking Stroke Study In The New England Journal Of Medicine 3