Navigation Links
Getting down to cancer basics
Date:3/29/2009

Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes. The new example - a gene on the X chromosome called UTX - is found in 10% of cases of multiple myeloma and 8% of esophageal cancers.

UTX plays a role in overall regulation of the activity of many genes and it is possible that other genes with similar roles will also be found to be involved in different tumor types. This is the first example of mutations in a gene of this functional class. The finding arose from a study of mutations in 4000 genes in kidney cancer.

"UTX is an important component of the transcriptional control machinery - it influences some of the most fundamental mechanisms controlling gene activity in our cells," explains Dr Andy Futreal, co-leader of the Cancer Genome Project at the Wellcome Trust Sanger Institute. "Unlike many cancer genes, UTX does not appear to be directly involved in cell division or cell death but in basic gene regulation and shows the depths to which cancers will plumb in order to get themselves ready to go."

The normal UTX protein modifies part of the structure holding DNA together in our cells. The composite DNAprotein structure, called chromatin, is not simply a scaffold, but plays an active role in controlling gene activity. The UTX protein alters a key organising subunit component of chromatin, called a histone. The protein is likely to be involved in both turning genes on and off, making it a key regulator of the yin-yang of gene control.

In the massive DNA sequencing study, the team found rare mutations of the UTX gene in clear cell renal cancer - a type of kidney cancer. When they expanded the search they found mutations in many cancer types - including one in ten multiple myeloma and one in twelve esophageal cancer cases.

"This work shows that mutations in genes with different functions can be found in human cancer through systematic a
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The sea ice is getting thinner
2. Getting wise to the influenza virus tricks
3. Getting better with a little help from our micro friends
4. Getting to the root of the matter
5. Getting warmer? Prehistoric climate can help forecast future changes
6. Many middle-aged and older Americans not getting adequate nutrition
7. Getting into hot water
8. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
9. A study by the MUHC and McGill University opens a new door to understanding cancer
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. Protein chatter linked to cancer activation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... 2014 C-Labs LLC, a leading provider of ... (IoT), today announced the appointment of John Traynor ... a strategic advisor to the firm, Mr. Traynor will ... is based out of the C-Labs office in ... Chris Muench , Chief Executive Officer. Photo ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... (June 21, 2012) Autism Speaks, the world,s leading ... of new research grants totaling nearly $2.9 million in ... extraordinarily proud of Autism Speaks, not only for funding ... avenues to understanding autism," said Autism Speaks Co-founder Bob ...
... ocean infrastructure development to tap energy sources such as ... pile driving, the practice of pounding long, hollow steel ... energy turbines and other structures. But pile driving creates ... marine animals., Many scientists and regulators have assumed that ...
... world are preparing to address the urgent need to ... biodiversity. The Global Biodiversity Informatics Conference (GBIC) will ... and policy in Copenhagen, Denmark from 2-4 July. ... strategy and roadmap to make best use of the ...
Cached Biology News:Autism Speaks awards nearly $2.9 million to fund autism research 2Autism Speaks awards nearly $2.9 million to fund autism research 3Autism Speaks awards nearly $2.9 million to fund autism research 4Turning down the dial: Ocean energy development with less sound 2Turning down the dial: Ocean energy development with less sound 3Turning down the dial: Ocean energy development with less sound 4A new vision for harnessing data about life on Earth 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... ST. LOUIS, Feb. 3, 2011 Monsanto Company (NYSE: ... conjunction with a presentation by Kerry Preete, senior vice president ...  Preete,s presentation will begin at 2:30 p.m. E.T. Feb. 9. ... and operational path, financial targets and other matters related to ...
... CITY, Calif., Feb. 3, 2011 Genomic Health, ... that its scientists successfully surveyed expression of the ... developed by Illumina, Inc., to test hypotheses for ... tissue samples.  The study identified hundreds of coding ...
... Researchers from the Institute of Biotechnology and Biomedicine and ... developed and patented a method using Saccharomyces cerevisiae ... of oligomers, small toxic aggregations of molecules which can ... diseases. The test allows validating the efficacy of compounds ...
Cached Biology Technology:Genomic Health Announces Results from Biomarker Discovery Program Utilizing Next-Generation Sequencing to Compare Normal and Tumor Breast Tissue 2Genomic Health Announces Results from Biomarker Discovery Program Utilizing Next-Generation Sequencing to Compare Normal and Tumor Breast Tissue 3Genomic Health Announces Results from Biomarker Discovery Program Utilizing Next-Generation Sequencing to Compare Normal and Tumor Breast Tissue 4New test to study proteins involved in neurodegenerative diseases 2
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: