Navigation Links
Getting a step ahead of pathogens
Date:7/27/2010

College Park, MD (July 27, 2010) -- In biology and genetics, the concept of epistasis is what gives rise to the whole being more (or less) than the sum of its parts. The quantitative effect of a given mutation upon the traits of an organism has the potential to depend strongly upon the gene versions present in other parts of the genome, or even other mutations co-occurring in that gene. These genetic interactions, termed epistasis, can impact all aspects of organisms and play a pivotal role in the manifestation of sex, ploidy, modularity, robustness, reproductive isolation and the origin of species, the rate of adaptation, and the emergence of genetic mutations within individuals and populations. A recent article in the journal Chaos, published by the American Institute of Physics, examines the possibility of using epistasis to predict the outcome of the evolutionary processes, especially when the evolving units are pathogens such as viruses.

The article looks at three topics: empirical evidence from the RNA virus world, mathematical tools, and the application of these tools to particular problems. Santiago Elena and colleagues at Instituto de Biologa Molecular y Celular de Plantas have surveyed past work in this field and concluded that even though RNA viruses have small genomes composed of few genes that encode a limited number of proteins, epistasis is abundant and conditions their evolution. The next steps may range from characterizing the statistical distributions of epistasis across hosts, which has tremendous relevance for the emergence of new viruses, to drawing the most likely evolutionary paths a virus may follow in response to treatments with antiviral drugs.

While this research is still in the early stages, Elena sees great potential.

"By increasing our ability to predict the most likely evolutionary paths a virus may follow in response to clinical treatments, we could get a step ahead of them and, perhaps, create new and more durable antiviral therapies," he says.


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Getting warmer? Prehistoric climate can help forecast future changes
2. Many middle-aged and older Americans not getting adequate nutrition
3. Getting into hot water
4. Getting down to cancer basics
5. Getting to the root of science in a nutty way
6. Getting plants to rid themselves of pesticide residues
7. Getting a leg up on whale and dolphin evolution
8. Getting down to details
9. Most patients gain weight after getting a new knee, UD study finds
10. Poor in rural Oregon face double binds when getting food
11. Getting turned on
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... -- According to a new market research report "Consumer IAM ... and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global ... grow from USD 14.30 Billion in 2017 to USD 31.75 Billion by ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding into ... a broad range of contract analysis services for advanced applications. Services will ...
(Date:10/6/2017)... ... 2017 , ... The HealthTech Venture Network (HTVN) is proud ... annual Conference where founders, investors, innovative practitioners and collaborators are invited to a ... early stage digital health and med tech companies. , This day-long event will ...
(Date:10/5/2017)... ... October 05, 2017 , ... Understanding the microbiome, the millions of bacteria ... Gut Love: You Are My Future, the newest exhibit on display at the University ... the human condition through the lens of the gut microbiome. , Gut Love ...
Breaking Biology Technology: