Navigation Links
Gestational diabetes linked to serotonin and dietary protein
Date:6/27/2010

in increase, but also the amount of serotonin in the beta cells increases 1,000-fold during pregnancy."

Beta cells are the specific islet cells that produce and release insulin and make up the majority of the cells found in the part of the pancreas known as the islets of Langerhans.

Why that happened was the next question. German said the amount of serotonin rises in the bloodstream during pregnancy, but only by about 50 percent. The magnitude of this change, in comparison, indicated that it had a local use.

"We looked to see whether beta cells have receptors for serotonin, and in fact they do," he said. "We realized that this must be controlling beta cell proliferation."

Sure enough, German added, anything the lab did to inhibit production of serotonin by islet cells, including restricting tryptophan in the diet, caused the cells to stop proliferating and led to gestational diabetes in the mice.

The researchers discovered that as the hormone prolactin increases at the onset of pregnancy, it activates the gene that produces Tph1 in beta cells. That stimulates serotonin receptors and causes beta cells to proliferate, generating the increase in insulin.

The research indicates that modulators of the serotonin pathway, including drugs, diet and genetic inheritance, may affect the risk of gestational diabetes and, possibly, the long-term risk of developing type 2 diabetes, according to the researchers. The dual roles of serotonin in regulating mood and beta cell mass also could explain the association of depression with both type 2 diabetes and gestational diabetes, as well as the effects of some classes of psychiatric medications on diabetes. The researchers noted that a more complete understanding of the function of this pathway could suggest improved methods for both preventing and treating diabetes.


'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Twice as many women to be diagnosed with gestational diabetes
2. Prepregnancy, obesity and gestational weight gain influence risk of preterm birth
3. Sugary cola drinks linked for first time to higher risk of gestational diabetes
4. Treating even mild gestational diabetes reduces birth complications
5. Severe gestational hypertension may protect against testicular cancer
6. No heart benefit from Omega-3 in women with type 1 diabetes
7. Insulin peptide may point to a solution for type 1 diabetes
8. Lexicon to Present Clinical Data for Diabetes Drug Candidate, LX4211, at Two Major Healthcare Conferences
9. Importance of insulin delivery devices for diabetes management
10. La Jolla Institute scientist leads team which discovers important new player in diabetes onset
11. Cell Transplantation reports consistent and successful islet isolations offer diabetes hope
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... pathogens posing the greatest risk to Europe based upon ... of Liverpool researchers using a ,big data, approach to ... of Infection and Global Health ranked the top 100 ... animals using a system which, they believe, will help ... the spread of infectious diseases, including as a result ...
(Date:8/27/2014)... . , Charcot-Marie-Tooth ... affecting the peripheral nervous system. Researchers from the Department ... Medicine and University Medical Centre Gttingen have discovered that ... with the disease. These cells enwrap the nerve fibres ... the rapid transfer of electrical impulses. If Schwann cells ...
(Date:8/27/2014)... Outstanding basic research, a growing focus on translating ... care have earned the Herbert Irving Comprehensive Cancer ... and NewYork-Presbyterian Hospital an $18 million, five-year Cancer ... (NCI). The grant renews the center,s status as ... in New York City and one of only ...
Breaking Biology News(10 mins):Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for incurable Charcot-Marie-Tooth disease 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... -- Two research groups from the University of Tennessee, ... Science Foundation to create new graduate research and education ... grants, called Integrative Graduate Education and Research Traineeships, or ... students to UT Knoxville for two unique programs that ...
... . , Since Monday of this week, the ... in Neuss, Germany, where it is being tested for safety ... has been in use since 1921, and has been genetically ... than its predecessor. The scientific basis for this was ...
... Philadelphia, PA, September 11, 2008 People who are ... and a "bad" snack might not follow their intentions ... September/October 2008 issue of the Journal of Nutrition ... is a substantial inconsistency between healthful snack choice intentions ...
Cached Biology News:UT Knoxville wins 2 $3M National Science Foundation research and education grants 2Clinical trial for new tuberculosis vaccine 2Making snack food choices 2
(Date:8/27/2014)... , Aug. 27, 2014  A novel biomarker ... help physicians better identify early-stage disease, when treatment ... according to a new study in The Journal ... (NYSE: DGX ) and other institutions ... protein outperformed conventional antibody-serum testing, including rheumatoid factor ...
(Date:8/27/2014)... Westminster, CO (PRWEB) August 27, 2014 ... image analysis services to the pharmaceutical and medical ... and expansion. The fast growing company has consolidated ... in Aurora and Boulder to Westminster, CO, just north ... and Histology Lab, 7575 W. 103rd Ave., Suite 100, ...
(Date:8/27/2014)... JUNCTION, N.J. , Aug. 27, 2014 ... innovative drug delivery technologies, today announced that it has ... Jersey Business & Industry Association,s 2014 Awards for ... were selected by an independent panel of judges from ... company volunteers. Award winners will be honored at a ...
(Date:8/27/2014)... According to the 2013 Raw Material and ... and feel of markets for raw materials and ingredient ... push for more branded, science-backed products.” , Natural products ... growth in the last decade as consumers increasingly demand ... to fit a more ‘wellness’ lifestyle approach. Due ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Flagship Biosciences Announces Relocation and Expansion 2Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3
... Md., Oct. 24 MedImmune, Inc. announced,today that ... recognized the company for its employees, exceptional commitment ... Volunteer Award,for a large business. "As the ... as an outstanding corporate citizen whose employees strive ...
... Oct. 24 Gene Codes Corporation, a,leading ... the next version of Sequencher, its award-winning,Deoxyribonucleic ... Researchers in academic labs and pharmaceutical ... the essential genetic instructions key to,an organism,s ...
... - Atrium Innovations Inc. (TSX:,ATB) will hold its ... Eastern,time on November 8, 2007. The call will ... results issued earlier the previous day.,Participants may access ... or 800-591-7539 or via the Company,s website at, ...
Cached Biology Technology:Gene Codes Corporation Announces Version 4.8 of Sequencher Software for DNA Sequence Assembly & Analysis 2Atrium Innovations to Hold 2007 Third Quarter Financial Results Conference Call and Webcast on November 8 2
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
... Dyad thermal cycler is a flexible ... chassis accommodates a variety of interchangeable ... hold different types and numbers of ... with point-and-click navigation. Peltier heat pumps, ...
... Immunophosphatase Secondary Detection System is intended for ... Primary Antibody reagents, which contain rat and ... antigens by light microscopy in paraffin-embedded tissues. ... may also be used with other rat ...
... FLISP Assay with SR-101 Labeled Substrates ... • Accurately measure serine protease activation ... • B-Bridge's FLISP Kits utilize cell-permeable, ... (FLISPs) to measure chymotrypsin-like activity in ...
Biology Products: