Navigation Links
Gestational diabetes linked to serotonin and dietary protein
Date:6/27/2010

The cause of diabetes during pregnancy is directly controlled by serotonin, a chemical produced by the body and normally known as a neurotransmitter, and is influenced by the amount of protein in the mother's diet early in pregnancy, according to new findings of an international team led by researchers at UCSF.

The surprise discovery could lead to simple dietary solutions and possible therapeutics for the disorder known as gestational diabetes, which if untreated, has serious implications for both mother and child. It also offers new insights into possible ways to reverse non-gestational diabetes in its early stages, the researchers say.

The findings will be reported in an upcoming issue of "Nature Medicine" and are available June 27 via Advance Online Publication at http://dx.doi.org/10.1038/nm.2173.

Scientists have puzzled for decades over the fact that the onset of pregnancy causes a woman to double the number of insulin-producing islet cells in her pancreas, according to UCSF Professor Michael German, MD, who is senior author of the paper. While that increase ultimately enables the mother to control the flow of nutrients to the fetus during its final growth spurt in the third trimester, the islet cell production occurs long before those nutrients are actually needed.

Until now, no one has known what caused that change. Clearly, German said, it is not stimulated by the need for nutrients at the time it occurs, so something else had to be causing it. That has made it of great interest to researchers studying gestational diabetes, in which too little insulin is produced, as well as type I diabetes, in which islet cells are killed off. German's team set out to find out why.

Using a genomic analysis of both pregnant and non-pregnant mice, the researchers conducted a broad scan of all of the genes that were turned either on or off in the islet cells during pregnan
'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Twice as many women to be diagnosed with gestational diabetes
2. Prepregnancy, obesity and gestational weight gain influence risk of preterm birth
3. Sugary cola drinks linked for first time to higher risk of gestational diabetes
4. Treating even mild gestational diabetes reduces birth complications
5. Severe gestational hypertension may protect against testicular cancer
6. No heart benefit from Omega-3 in women with type 1 diabetes
7. Insulin peptide may point to a solution for type 1 diabetes
8. Lexicon to Present Clinical Data for Diabetes Drug Candidate, LX4211, at Two Major Healthcare Conferences
9. Importance of insulin delivery devices for diabetes management
10. La Jolla Institute scientist leads team which discovers important new player in diabetes onset
11. Cell Transplantation reports consistent and successful islet isolations offer diabetes hope
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... shakes or jerks its head uncontrollably for no apparent ... syndromes in people, most notably trigeminal neuralgia, and headshaking ... both diagnosing and treating the condition in horses, the ... is needed. A recent study led ...
... world, the millipede lllacme plenipes , was re-discovered ... his colleagues provide further details of the surprisingly complex anatomy of ... of spots just south of San Francisco. More details about the ... was recently published in the open access journal ZooKeys ...
... new report have suggested that climate change is causing additional ... managers should consider a significant reduction, or in some places ... A growing degradation of grazing lands could be mitigated ... Forest Service lands became free of use by livestock and ...
Cached Biology News:Study investigates headshaking in horses 2The leggiest animal on Earth lives in the outskirts of Silicon Valley 2The leggiest animal on Earth lives in the outskirts of Silicon Valley 3Climate change increases stress, need for restoration on grazed public lands 2Climate change increases stress, need for restoration on grazed public lands 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... National Institutes of Health have turned simple baker,s yeast into ... for drugs to treat Parkinson,s disease. In a study ... researchers showed that they can rescue yeast cells from toxic ... the cells to make very small proteins called cyclic peptides. ...
... , WILMINGTON, Del., July 13 ParagonRx, a ... medications, has launched a new website - www.paragonrx.com ... companies needing information and assistance in complying with new FDA requirements ... and dangerous side effects. , , ...
... , , LEXINGTON, Mass. and HEIDELBERG, ... announced today the launch of the first human cancer biochip for ... Sequencing (NGS). The new catalog cancer biochip features 115 important genes ... by the Wellcome Trust Sanger Institute. , , ...
Cached Biology Technology:Novel drug discovery tool could identify promising new therapies for Parkinson's disease 2Novel drug discovery tool could identify promising new therapies for Parkinson's disease 3Novel drug discovery tool could identify promising new therapies for Parkinson's disease 4ParagonRx Creates New Website Featuring REMS Help Center for Pharma 2First Catalog Cancer Biochip for Sequence Capture Now Available from febit 2
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: