Navigation Links
Gerton Lab determines the composition of centromeric chromatin
Date:9/28/2009

The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell.

The centromeric nucleosome acts as a guide for the position of the kinetochore. The kinetochore attaches the chromosome to a microtubule for chromosome segregation. It is essential that chromosome segregation is carried out with high fidelity, since errors in this process can produce cells which contain an abnormal number of chromosomes. In humans, these types of errors are hallmarks of many types of cancer, and therefore are thought to play a significant role in tumor formation, malignancy, and metastasis.

For many years, researchers assumed that centromeric nucleosomes were structurally like other nucleosomes "octamers" with two copies each of four different histone protein subunits with DNA wrapped around the outside. Recently, two alternative models for the structure of centromeric nucleosomes have been proposed. The first suggests that two of the histone protein pairs normally found in the centromere are replaced by the Scm3 protein, creating a hexameric nucleosome made up of six subunits. The second model suggested that centromeric nucleosomes contain a single molecule of each of the four proteins, forming a tetrameric structure called a hemisome.

The Gerton Lab provides evidence for a model in which Cse4-containing nucleosomes are, in fact, octamers. A variety of unbiased methods was used to test the three different models, including genetic, biochemical, and cell biological approaches. In the end, the octamer model was the only one consistent with all of the current experimental results.

"These data support a new model for the structure of centromeric nucleosomes and
'/>"/>

Contact: Marie Jennings
mfj@stowers.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Response to immune protein determines pathology of multiple sclerosis
2. Improved technique determines structure in membrane proteins
3. Diet prior to pregnancy determines sheeps gender
4. New technique determines the number of fat cells remains constant in all body types
5. Gene determines whether male body odor smells pleasant
6. Study of isolated snakes could help shed light on venom composition
7. Breastfeeding duration and weaning diet may shape childs body composition
8. Tree species composition influences nitrogen loss from forests
9. Climate change causing significant shift in composition of coastal fish communities
10. Lets talk -- new paradigms in the research of the biomolecular composition of water
11. Does the victim affect snake venom composition?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... researchers and their colleagues have built the first ... academic performance and behavioral trends. In other words, ... even if you don,t -- and how that ... students, happiness, stress, depression and loneliness to their ... general population for example, to monitor mental ...
(Date:9/18/2014)... algal forests in the eastern Mediterranean Sea pose a ... distribution continues to expand as the climate warms, a ... of researchers led by Dr Adriana Vergs of UNSW ... for Advanced Studies in Spain, is published in the ... surveyed more than 1000 kilometres of coastline in Turkey ...
(Date:9/18/2014)... camouflage: you don,t just blend in, the background shows ... as you might think. Kathryn Feller, from the University ... life stages of many marine species are transparent. However, ... creatures cannot make transparent. Feller explains that the animals ... unit with an opaque pigment to prevent light leaking ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Tropical fish a threat to Mediterranean Sea ecosystems 2Transparent larvae hide opaque eyes behind reflections 2
... substance found in red grapes and red wine, may have ... to a published laboratory study from Henry Ford Hospital in ... likely to suffer the long-term effects of noise-induced hearing loss ... a long period of time. "Our latest study focuses ...
... to become knotted, thus it may be useful to disentangle ... at random (or better, in one solution) the filaments with ... solutions like, for instance, having the DNA pass through nano-pores ... may exploit to selectively let a type of molecule pass ...
... struggling to collect and analyze millions of gigabytes of ... National Institutes of Health has launched a $700 million ... training future scientists to tap that gold mine of ... current edition of Chemical & Engineering News ...
Cached Biology News:Study: Resveratrol shows promise to protect hearing, cognition 2The nano-channel that disentangles knots 2
(Date:9/18/2014)... , Sept. 18, 2014  Health Enhancement Products, Inc. (OTCQB: ... early-stage algae bioactive compounds and metabolic processes, is pleased to ... board of directors. Ms. Nola E. Masterson , a ... joined the board effective September 17, 2014. ... to join our board," states Andrew Dahl , President ...
(Date:9/18/2014)... Research and Markets has ... Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on ... The report provides a basic overview ... industry chain structure. The N-acetylcysteine market analysis is ...
(Date:9/18/2014)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology ... cancer, announced today that Daniel P. Gold , Ph.D., ... NewsMakers in the Biotech Industry conference on Friday, September ... Broadway Hotel & Conference Center in New York ... accessed at www.meipharma.com . A replay will be available ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 OMICS ... the globe to participate in the ‘Open Access ... articles to OMICS Group Pharma Journals ... one of the fastest emerging Sciences, accelerating with ... healthcare services across the globe. The industry is ...
Breaking Biology Technology:Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Global N-acetylcysteine Industry Report 2014 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... - In order to enhance the worldwide launch of ... has formed a strategic marketing alliance with the globally operating ... food proof® range which has been available in almost ... new products will be launched jointly during the year 2008. ...
... VANCOUVER, April 18 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. ... global specialty pharmaceutical and,medical device company, today ... "BSC" (NYSE: BSX ) has received ... paclitaxel-eluting coronary stent system in Canada.,BSC reported ...
... 18 Cell Therapeutics, Inc.,(CTI) (Nasdaq and MTAX: CTIC) ... letter from The NASDAQ Stock Market indicating that for ... its common stock has closed,below the minimum $1.00 per ... notification has no immediate effect on,the listing of or ...
Cached Biology Technology:BIOTECON Diagnostics and MERCK KGaA start worldwide marketing alliance 2BIOTECON Diagnostics and MERCK KGaA start worldwide marketing alliance 3Angiotech's Corporate Partner, Boston Scientific, Reports Canadian Approval for TAXUS(R) Liberte(R) Stent System 2Angiotech's Corporate Partner, Boston Scientific, Reports Canadian Approval for TAXUS(R) Liberte(R) Stent System 3Angiotech's Corporate Partner, Boston Scientific, Reports Canadian Approval for TAXUS(R) Liberte(R) Stent System 4Cell Therapeutics, Inc. Announces Receipt of Letter From the NASDAQ Stock Market Regarding Non-Compliance With the Minimum Bid Price Requirement 2