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Genomics and social network analysis team up to solve disease outbreaks
Date:5/22/2011

NEW ORLEANS, LA May 22, 2011 -- Combining the cutting-edge technology of whole genome sequencing of bacteria with social networking analysis, public health officials can get a more detailed picture of disease outbreaks that will better help track and stop them, say researchers today at the 111th General Meeting of the American Society for Microbiology.

"Public health agencies are now able to harness the power of genome sequencing, which, when combined with the detailed clinical and epidemiological data we have access to, allows us to reconstruct outbreaks and really understand how a pathogen moves through a population," says Jennifer Gardy of the British Columbia Center for Disease Control, presenting a case study where she and her colleagues used this new technique to track and eventually stop a tuberculosis outbreak in the province.

An outbreak of tuberculosis occurred over a 3-year period in a medium-sized community in British Columbia. In order to stop the event, public health officials turned to traditional epidemiological methods to identify the source and other contributing factors, but the results were hazy.

The researchers combined two new tools to get a clearer picture of the outbreak: social network analysis, which has become increasingly common in tracking infectious diseases in the past decade, and whole-genome sequencing (analysis of the entire microbe's DNA), which has become cheaper and less time-consuming over the past few years.

"The complete genome sequence of a pathogen is the ultimate DNA fingerprint, and now, with the costs and time associated with genome sequencing dropping almost exponentially, it is possible to sequence most or all of the bacterial isolates taken from and outbreak," says Gardy

And while it may sound like something having to do with Facebook, social network analysis takes traditional epidemiology one step further, asking patients about more than just with whom they have bee
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Contact: Jim Sliwa
jsliwa@asmusa.org
American Society for Microbiology
Source:Eurekalert

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