Navigation Links
Genomic 'haircut' makes world's tiniest genome even smaller: UBC research
Date:9/21/2010

The world's tiniest nuclear genome appears to have "snipped off the ends" of its chromosomes and evolved into a lean, mean, genome machine that infects human cells, according to research published today by University of British Columbia scientists.

Until recently, E. cuniculi, a parasitic fungus commonly found in rabbits that can also be fatal to immunocompromised humans, has been widely regarded as having the smallest known nuclear genome. At 2.9 millions base pairs (Mbp) and approximately 2,000 genes, the genome of E. cuniculi is less than one-two thousandth the size of the human genome.

But now, a team of researchers led by UBC Botany Prof. Patrick Keeling sequenced the genome of a closely related parasite that makes the E. cuniculi genome seem positively king-sized. The genome of E. intestinalis, a sister species of E. cuniculi that infects human intestines, is 20 per cent smaller, at only 2.3Mbp.

"On one end of the spectrum, genomes can get larger almost without limit, but there is a limit to how small they can get they can't be less than zero," says Keeling, whose work is published in today's issue of the journal Nature Communications. "And the question that fascinated us was 'in an already tiny genome, what else can be lost'?"

Keeling and a team of researchers from Switzerland, Canada and the U.S. compared the genome of E. cuniculi and E. intestinalis and found little difference between the chromosome "cores" but that the ends were all "trimmed" in E. intestinalis.

"The chromosomes are long threads of DNA, and in E. intestinalis its almost as though it got a haircut, removing hundreds of genes, but all from the ends of the threads," says Keeling.

Keeling, director of the Centre for Microbial Diversity and Evolution and a member of Beaty Biodiversity Research Centre at UBC, says the discovery provides insights into how genomes evolve, especially in extreme conditions.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. NIH expands key pharmacogenomics resource
2. Genomic sequencing of marine sponge published; revealed early genetic complexity and roots of cancer
3. New biotech company grows from MCG diabetes and genomic research
4. New TGen technology reduces storage needs and costs for genomic data
5. Paper offers new insights into the genomics of speciation
6. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
7. Dr. Alecia Willis honored as the 2010 Signature Genomic Laboratories Travel Award winner
8. MIT student inventor honored for transformative work in genomics and linguistics
9. The impact of genomics
10. NSF awards $7.5M grant to University of Oklahoma for plant genomics
11. Beyond genomics, biologists and engineers decode the next frontier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... the addition of the "Global Facial ... offering. --> http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... Markets ( http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the ...
(Date:2/4/2016)... The field of Human Microbiome research ... popular hubs of the biotechnology industry. While the ... of human microbiota, have garnered a lot of ... space has literally exploded in terms of both ... focuses on biomedical aspects of research, development, and ...
(Date:2/3/2016)... --> --> Fourth quarter 2015:   ... compared with fourth quarter of 2014. Gross margin was 46% ... Earnings per share increased to SEK 6.39 (loss: 0.49). ... , --> --> January ... (233.6), up 1,142% compared with 2014. Gross margin was 43% ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... --> --> ... Point-Of-Care (POC) molecular diagnostics company, today announces that it has ... to be launched on the Company,s io® platform. By meeting ... is now cleared for sale within the European Union. ... the io® CT test signals a new era in ultra-rapid ...
(Date:2/6/2016)... McLean, VA (PRWEB) , ... February 06, 2016 , ... ... enrichment session, cost-free, for middle and high school teachers on Wednesday February 10, 2016. ... be held at the Smithsonian-Mason School of Conservation, located at 1500 Remount Road in ...
(Date:2/6/2016)... , ... February 06, 2016 , ... ... , The Center for Excellence in Education Sponsors Teacher Training Program , ... February 4, 2016 – The Center for Excellence in Education (CEE) will sponsor ...
(Date:2/5/2016)... , Feb. 5, 2016 ATCC, the premier ... to assist the medical and life science researchers that ... Virus infection.   CDC website . ... Zika virus is a single-stranded RNA virus of ... West Nile, Dengue and Chikungunya Viruses. Zika virus is ...
Breaking Biology Technology: