Navigation Links
Genomic 'haircut' makes world's tiniest genome even smaller: UBC research
Date:9/21/2010

The world's tiniest nuclear genome appears to have "snipped off the ends" of its chromosomes and evolved into a lean, mean, genome machine that infects human cells, according to research published today by University of British Columbia scientists.

Until recently, E. cuniculi, a parasitic fungus commonly found in rabbits that can also be fatal to immunocompromised humans, has been widely regarded as having the smallest known nuclear genome. At 2.9 millions base pairs (Mbp) and approximately 2,000 genes, the genome of E. cuniculi is less than one-two thousandth the size of the human genome.

But now, a team of researchers led by UBC Botany Prof. Patrick Keeling sequenced the genome of a closely related parasite that makes the E. cuniculi genome seem positively king-sized. The genome of E. intestinalis, a sister species of E. cuniculi that infects human intestines, is 20 per cent smaller, at only 2.3Mbp.

"On one end of the spectrum, genomes can get larger almost without limit, but there is a limit to how small they can get they can't be less than zero," says Keeling, whose work is published in today's issue of the journal Nature Communications. "And the question that fascinated us was 'in an already tiny genome, what else can be lost'?"

Keeling and a team of researchers from Switzerland, Canada and the U.S. compared the genome of E. cuniculi and E. intestinalis and found little difference between the chromosome "cores" but that the ends were all "trimmed" in E. intestinalis.

"The chromosomes are long threads of DNA, and in E. intestinalis its almost as though it got a haircut, removing hundreds of genes, but all from the ends of the threads," says Keeling.

Keeling, director of the Centre for Microbial Diversity and Evolution and a member of Beaty Biodiversity Research Centre at UBC, says the discovery provides insights into how genomes evolve, especially in extreme conditions.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. NIH expands key pharmacogenomics resource
2. Genomic sequencing of marine sponge published; revealed early genetic complexity and roots of cancer
3. New biotech company grows from MCG diabetes and genomic research
4. New TGen technology reduces storage needs and costs for genomic data
5. Paper offers new insights into the genomics of speciation
6. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
7. Dr. Alecia Willis honored as the 2010 Signature Genomic Laboratories Travel Award winner
8. MIT student inventor honored for transformative work in genomics and linguistics
9. The impact of genomics
10. NSF awards $7.5M grant to University of Oklahoma for plant genomics
11. Beyond genomics, biologists and engineers decode the next frontier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:7/24/2017)... , July 24, 2017 Intralytix, Inc. ... funding from Lesaffre, a French family group. This investment ... companies to develop and commercialize bacteriophage-based products, for various ... mutual interest. ... Lesaffre designs manufactures and markets innovative solutions for baking, ...
(Date:7/24/2017)... , ... July 24, 2017 ... ... Kenny Soulstring, today announced that the stock market news outlet had initiated ... assessment diagnostic testing that screens and identifies exposure, progression and risk analysis ...
(Date:7/20/2017)... ... 2017 , ... Resoundant, Inc. is pleased to introduce ... U.S. that offer MR Elastography for liver fibrosis staging. MR Elastography is ... liver fibrosis assessment. , “MRE:connect was created in response to an increasing number ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... of life, today announced its full advisory board. The board comprises leaders spanning ... of James Crooks, PhD, former VP of Engineering, to Chief Technology Officer. Crooks ...
Breaking Biology Technology: