Navigation Links
Genomic 'haircut' makes world's tiniest genome even smaller: UBC research
Date:9/21/2010

The world's tiniest nuclear genome appears to have "snipped off the ends" of its chromosomes and evolved into a lean, mean, genome machine that infects human cells, according to research published today by University of British Columbia scientists.

Until recently, E. cuniculi, a parasitic fungus commonly found in rabbits that can also be fatal to immunocompromised humans, has been widely regarded as having the smallest known nuclear genome. At 2.9 millions base pairs (Mbp) and approximately 2,000 genes, the genome of E. cuniculi is less than one-two thousandth the size of the human genome.

But now, a team of researchers led by UBC Botany Prof. Patrick Keeling sequenced the genome of a closely related parasite that makes the E. cuniculi genome seem positively king-sized. The genome of E. intestinalis, a sister species of E. cuniculi that infects human intestines, is 20 per cent smaller, at only 2.3Mbp.

"On one end of the spectrum, genomes can get larger almost without limit, but there is a limit to how small they can get they can't be less than zero," says Keeling, whose work is published in today's issue of the journal Nature Communications. "And the question that fascinated us was 'in an already tiny genome, what else can be lost'?"

Keeling and a team of researchers from Switzerland, Canada and the U.S. compared the genome of E. cuniculi and E. intestinalis and found little difference between the chromosome "cores" but that the ends were all "trimmed" in E. intestinalis.

"The chromosomes are long threads of DNA, and in E. intestinalis its almost as though it got a haircut, removing hundreds of genes, but all from the ends of the threads," says Keeling.

Keeling, director of the Centre for Microbial Diversity and Evolution and a member of Beaty Biodiversity Research Centre at UBC, says the discovery provides insights into how genomes evolve, especially in extreme conditions.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. NIH expands key pharmacogenomics resource
2. Genomic sequencing of marine sponge published; revealed early genetic complexity and roots of cancer
3. New biotech company grows from MCG diabetes and genomic research
4. New TGen technology reduces storage needs and costs for genomic data
5. Paper offers new insights into the genomics of speciation
6. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
7. Dr. Alecia Willis honored as the 2010 Signature Genomic Laboratories Travel Award winner
8. MIT student inventor honored for transformative work in genomics and linguistics
9. The impact of genomics
10. NSF awards $7.5M grant to University of Oklahoma for plant genomics
11. Beyond genomics, biologists and engineers decode the next frontier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... 2017 Optimove , provider of ... such as 1-800-Flowers and AdoreMe, today announced two ... Replenishment. Using Optimove,s machine learning algorithms, these features ... replenishment recommendations to their customers based not just ... customer intent drawn from a complex web of ...
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in Germany ... ... in one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial ... ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... ... Franz Inc ., the leading supplier of Semantic Graph Database technology, ... by Bloor Research in its recent Graph Database Market Update report. ... Gruff, it was rated as the easiest product to use.” – Bloor Research , ...
(Date:3/28/2017)... WASHINGTON , March 28, 2017 /PRNewswire/ ... launch single-cell sequencing during the American Association for Cancer ... Convention Center in Washington, D.C. , ... differential gene expression of thousands of cells at the ... Experts on-hand at AACR to discuss ...
(Date:3/28/2017)... HOLLISTON, Mass. , March 28, 2017 ... "Company"), a biotechnology company developing bioengineered organ implants to ... bronchus and trachea, today announced that Jim McGorry, ... 3D Printing and BioEngineering panel at the ... 2017 at 2:30 PM ET in Cambrige, Massachussetts. The ...
(Date:3/28/2017)... -RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSXV: RP) (FRA:P6P2) ("RepliCel" ... clinical data from its phase 1/2 tendon repair study investigating ... (RCT-01) as a treatment for Achilles tendinosis. ... The clinical trial ... 6 months and showed no serious adverse events related to ...
Breaking Biology Technology: