Navigation Links
Genomic 'haircut' makes world's tiniest genome even smaller: UBC research
Date:9/21/2010

The world's tiniest nuclear genome appears to have "snipped off the ends" of its chromosomes and evolved into a lean, mean, genome machine that infects human cells, according to research published today by University of British Columbia scientists.

Until recently, E. cuniculi, a parasitic fungus commonly found in rabbits that can also be fatal to immunocompromised humans, has been widely regarded as having the smallest known nuclear genome. At 2.9 millions base pairs (Mbp) and approximately 2,000 genes, the genome of E. cuniculi is less than one-two thousandth the size of the human genome.

But now, a team of researchers led by UBC Botany Prof. Patrick Keeling sequenced the genome of a closely related parasite that makes the E. cuniculi genome seem positively king-sized. The genome of E. intestinalis, a sister species of E. cuniculi that infects human intestines, is 20 per cent smaller, at only 2.3Mbp.

"On one end of the spectrum, genomes can get larger almost without limit, but there is a limit to how small they can get they can't be less than zero," says Keeling, whose work is published in today's issue of the journal Nature Communications. "And the question that fascinated us was 'in an already tiny genome, what else can be lost'?"

Keeling and a team of researchers from Switzerland, Canada and the U.S. compared the genome of E. cuniculi and E. intestinalis and found little difference between the chromosome "cores" but that the ends were all "trimmed" in E. intestinalis.

"The chromosomes are long threads of DNA, and in E. intestinalis its almost as though it got a haircut, removing hundreds of genes, but all from the ends of the threads," says Keeling.

Keeling, director of the Centre for Microbial Diversity and Evolution and a member of Beaty Biodiversity Research Centre at UBC, says the discovery provides insights into how genomes evolve, especially in extreme conditions.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. NIH expands key pharmacogenomics resource
2. Genomic sequencing of marine sponge published; revealed early genetic complexity and roots of cancer
3. New biotech company grows from MCG diabetes and genomic research
4. New TGen technology reduces storage needs and costs for genomic data
5. Paper offers new insights into the genomics of speciation
6. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
7. Dr. Alecia Willis honored as the 2010 Signature Genomic Laboratories Travel Award winner
8. MIT student inventor honored for transformative work in genomics and linguistics
9. The impact of genomics
10. NSF awards $7.5M grant to University of Oklahoma for plant genomics
11. Beyond genomics, biologists and engineers decode the next frontier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... PUNE, India , January 12, 2017 A new report ... 2022," projects that the global biometric technology market is expected to generate revenue of ... Continue Reading ... Allied ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
(Date:1/6/2017)... 2017  Delta ID Inc., a leader in consumer-grade ... automotive at CES® 2017. Delta ID has collaborated with ... the use of iris scanning as a secure, reliable ... in a car, and as a way to elevate ... Delta ID and Gentex will demonstrate (booth #7326 ...
(Date:12/22/2016)... 2016 SuperCom (NASDAQ:   ... the e-Government, Public Safety, HealthCare, and Finance sectors announced today that ... selected to implement and deploy a community-based supportive services program to ... , further expanding its presence in the state. ... This new program, which is ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... (PRWEB) , ... January 12, 2017 , ... Each year, ... Eureka Index – a process that evaluates the patent estate of a company, its ... LLC , a biomedical firm leading the way in technologies that transform energy sources ...
(Date:1/12/2017)... ... 12, 2017 , ... Huffman Engineering, Inc. , a leader in control ... the company’s Lincoln office as a chemical engineer. In his new role, Beck ... in the life science manufacturing and water/wastewater industries. , Prior to joining Huffman Engineering, ...
(Date:1/12/2017)... , January 12, 2017 The ... world,s biggest facility for producing mycorrhizae. The Centre for ... tapping potential of mycorrhizae and developed a technology that ... ... The TERI facility has a ...
(Date:1/12/2017)... 12, 2017 A new report published by Allied Market Research ... Opportunity Analysis and Industry Forecast, 2014-2022," projects that the global in vitro toxicity testing ... a CAGR of 15.07% during the forecast period. Continue ... ... ...
Breaking Biology Technology: