Navigation Links
Genomic 'haircut' makes world's tiniest genome even smaller: UBC research
Date:9/21/2010

The world's tiniest nuclear genome appears to have "snipped off the ends" of its chromosomes and evolved into a lean, mean, genome machine that infects human cells, according to research published today by University of British Columbia scientists.

Until recently, E. cuniculi, a parasitic fungus commonly found in rabbits that can also be fatal to immunocompromised humans, has been widely regarded as having the smallest known nuclear genome. At 2.9 millions base pairs (Mbp) and approximately 2,000 genes, the genome of E. cuniculi is less than one-two thousandth the size of the human genome.

But now, a team of researchers led by UBC Botany Prof. Patrick Keeling sequenced the genome of a closely related parasite that makes the E. cuniculi genome seem positively king-sized. The genome of E. intestinalis, a sister species of E. cuniculi that infects human intestines, is 20 per cent smaller, at only 2.3Mbp.

"On one end of the spectrum, genomes can get larger almost without limit, but there is a limit to how small they can get they can't be less than zero," says Keeling, whose work is published in today's issue of the journal Nature Communications. "And the question that fascinated us was 'in an already tiny genome, what else can be lost'?"

Keeling and a team of researchers from Switzerland, Canada and the U.S. compared the genome of E. cuniculi and E. intestinalis and found little difference between the chromosome "cores" but that the ends were all "trimmed" in E. intestinalis.

"The chromosomes are long threads of DNA, and in E. intestinalis its almost as though it got a haircut, removing hundreds of genes, but all from the ends of the threads," says Keeling.

Keeling, director of the Centre for Microbial Diversity and Evolution and a member of Beaty Biodiversity Research Centre at UBC, says the discovery provides insights into how genomes evolv
'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. NIH expands key pharmacogenomics resource
2. Genomic sequencing of marine sponge published; revealed early genetic complexity and roots of cancer
3. New biotech company grows from MCG diabetes and genomic research
4. New TGen technology reduces storage needs and costs for genomic data
5. Paper offers new insights into the genomics of speciation
6. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
7. Dr. Alecia Willis honored as the 2010 Signature Genomic Laboratories Travel Award winner
8. MIT student inventor honored for transformative work in genomics and linguistics
9. The impact of genomics
10. NSF awards $7.5M grant to University of Oklahoma for plant genomics
11. Beyond genomics, biologists and engineers decode the next frontier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 The Defense Logistics Agency ... to detect and prevent counterfeit microcircuits from entering ... agency started performing an in-house microcircuit anti-counterfeit initiative ... authenticity of purchased microcircuits while increasing their reliability ... measures will be conducted at DLA,s Electronics Product ...
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... LANSING, Mich. Most organisms would die in the ... simple algae call it home, and their secrets to ... Garavito, Michigan State University professor of biochemistry and molecular ... how primitive red algae use horizontal gene transfer, in ...
... (Bronx, NY) Researchers at Albert Einstein College ... $12 million grant from the National Institutes of Health (NIH) ... in women. "As we move into the fourth decade ... impact on women, particularly in sub-Sahara Africa," said principal investigator ...
... the Wildlife Conservation Society Canada (WCS Canada) creates a ... in the Southern Canadian Rockies to the future impacts ... "safe passages and safe havens" were informed in ... westslope cutthroat trout, grizzly bears, wolverines, mountain goats and ...
Cached Biology News:Home toxic home 2Einstein receives $12 million grant to develop device for preventing HIV infection 2Einstein receives $12 million grant to develop device for preventing HIV infection 3'Climate-smart strategies' proposed for spectacular US-Canadian landscape 2
(Date:12/22/2014)... 22, 2014  ( www.competitivehealth.com ) — Competitive Health ... bill review and advocacy service, has signed an agreement ... Savings discount health services marketplace. 63% of ... than they expected to pay. As part of an ... WellCard Savings is pleased to offer medical bill review ...
(Date:12/19/2014)... 2014 Charm Sciences is pleased to ... Detection of Aflatoxin M1 in raw commingled milk is ... party validation. The peer reviewed report of the validation ... for Agricultural and Fisheries Research (ILVO-T&V) has been published ... B1, the most toxic aflatoxin and a known carcinogen, ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources Group ... grow at a 12 percent compound annual growth rate ... the aging population and the increasing adoption of dental ... will also spur demand for dental biomaterials ... implant and periodontal treatments. Other key findings ...
(Date:12/19/2014)... Ed Bilsky, Ph.D., vice president for ... Excellence in the Neurosciences (CEN), and professor of pharmacology ... as a member of the prestigious Dana Alliance for ... Maine to receive this honor. , The Dana ... the Dana Foundation. Its mission is to advance ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3
... 26 Shasta Regional Medical Center,has earned the ... demonstrating,compliance with the Joint Commission,s national standards for ... has been awarded its full,accreditation. , ... an unannounced, initial on-site evaluation,of Shasta Regional Medical ...
... ORANGE COUNTY, Calif., Nov. 25 Beckman Coulter, Inc. (NYSE: ... of products that simplify, automate, and innovate complex biomedical testing, ... Strategy and Business Development, will present at the following conferences: ... http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) , , , ...
... (Nasdaq: SIAL ),announced today it has entered ... This collaboration is expected to support,the development and ... a planned launch of many of these products in ... tools for regenerative medicine,are expected to consist of serum-free ...
Cached Biology Technology:Shasta Regional Medical Center Awarded Full Accreditation from the Joint Commission 2Shasta Regional Medical Center Awarded Full Accreditation from the Joint Commission 3Beckman Coulter to Present at Upcoming Healthcare Conferences 2Sigma-Aldrich Enters Into Research Collaboration Program With D-Finitive Cell Technologies, Inc., to Develop Research Tools for Regenerative Medicine 2Sigma-Aldrich Enters Into Research Collaboration Program With D-Finitive Cell Technologies, Inc., to Develop Research Tools for Regenerative Medicine 3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5...
...
RayBio L Series 507: RayBio Label-based Antibody Array I (1 glass slide with 2 subarrays) Class: Antibody Array Products Product Group: Antibody Array...
Rat CXCL7/Thymus Chemokine-1 DuoSet Economy Pack, 45 Plate...
Biology Products: