Navigation Links
Genomes of identical twins reveal epigenetic changes that may play role in lupus
Date:12/21/2009

despread changes in DNA methylation status at a significant number of genes. Dr. Esteban Ballestar, senior author of the study, noted that this is the largest number of genes exhibiting DNA methylation changes observed in an autoimmune disease to date, and includes genes previously implicated in SLE pathogenesis. Importantly, Ballestar's team found that a significant number of the novel differentially methylated genes are related to multiple immune system functions and are potentially linked to SLE.

"Our study suggests that the effect of the environment or differences in lifestyle may leave a molecular mark in key genes for immune function that contributes to the differential onset of the disease in twins," Ballestar said. Most studies of DNA methylation and human disease have been in the context of cancer research, Ballestar noted, and he hopes that this work will attract more researchers to also investigate DNA methylation alterations in autoimmune disease and other disorders for the development of therapies.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. International team compares 12 fruit fly genomes
2. Scientists decode genomes of diverse TB isolates
3. Latest Integrated Microbial Genomes data management system update release
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
6. New computational technique allows comparison of whole genomes as easily as whole books
7. After dinosaurs, mammals rise but their genomes get smaller
8. Genomes reveal bacterial lifestyles: Research
9. Genomes of 2 popular research strains of E. coli sequenced
10. Singapore scientists join international study of 10,000 vertebrates genomes
11. Identical twins not as identical as believed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... people lived on the land now called California, and ... availability of plants they used for food, fuel, tools, ... maintain desired habitat and natural resources. , Frank Lake, ... Station, will lead a field trip to ... Society of America,s 99th Annual Meeting, in Sacramento, Cal. ...
(Date:7/25/2014)... 2014)The link between autism and disrupted brain development ... the disease, and is largely unknown. However, thanks ... Initiative (SFARI), George Washington University (GW) researcher Anthony-Samuel ... integrative and in-depth answers to these key questions ... LaMantia, professor of pharmacology and physiology at the ...
(Date:7/25/2014)... engineering at the University of Houston, has written ... organ development., "Introduction to Tissue Engineering: Applications and ... the field of artificial organ development. Metin Akay, ... UH, served as a series editor on the ... published books on the subject of growing artificial ...
Breaking Biology News(10 mins):Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3GW researcher receives grant to answer the how and why of autism during development 2University of Houston researcher publishes textbook on tissue engineering 2
... cells called macrophages can destroy tumor cells by producing ... the environment inside the tumor somehow halts this production ... promote tumor growth. The new study ... switch. This protein normally stimulates protective inflammation. But in ...
... ability every aging Hollywood star would envy: they can ... the May 19 issue of the Journal of ... London, UK) and collogues have pinned down a protein ... that might help researchers understand why myelin production falters ...
... Fla. (May 19, 2008) The current issue of ... by researchers seeking new ways to treat Parkinsons disease ... and slowed physical movements related to insufficient levels of ... by using primate models to examine the potential therapy ...
Cached Biology News:Neural cell transplants may help those with Parkinson's disease 2Neural cell transplants may help those with Parkinson's disease 3
(Date:7/24/2014)... 2014  ECC West Africa, LLC (ECC) signed a ... University College Hospital (UCH) Ibadan Board of Management for ... design, construct, and operate and maintain a new, state-of-the-art ... Under the first of the 4-phase project, ECC will ... applications. UCH Ibadan intends to finance and develop the ...
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Cell Culture Market 2014-2018" report to their offering.  ... Cell culture is the in vitro growth of plant ... cell studies, and biopharmaceutical production. Cell culture is a ... culture instruments and cell culture consumables are necessary for ...
(Date:7/24/2014)... Calif. , July 24, 2014 SRI ... contract with the National Institute of Allergy and Infectious ... to conduct preclinical development of potential therapies for HIV ... drugs to treat HIV and AIDS and the complications ... as microbicides for preventing sexual transmission of HIV. ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... RADI Medical Systems today,announced improvements to their ... which will begin shipments immediately., (Photo: ... generation of the PressureWire(R) Certus features a ... key,advantages for physicians. The new large entry ...
... /Xinhua-PRNewswire-FirstCall/ -- China-Biotics,Inc. (OTC Bulletin Board: CHBT) ... in the manufacture, research, development,marketing and distribution ... China-Biotics, Chief Technology Officer, has been invited ... Annual Food Safety Technology Forum,2008 (the "Forum")., ...
... Milestones and Maintain ... Commitment to Strategy, ... Inc.,(TSX: MGI, OTC: MGIFF), a clinical-stage developer of drugs for ... shareholders,for the purpose of acquiring control of MIGENIX,s board of ...
Cached Biology Technology:RADI Medical Systems Launches Next Generation PressureWire(R) Certus 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 3MIGENIX Corporate Update and Requisition of Special Meeting 2MIGENIX Corporate Update and Requisition of Special Meeting 3MIGENIX Corporate Update and Requisition of Special Meeting 4MIGENIX Corporate Update and Requisition of Special Meeting 5MIGENIX Corporate Update and Requisition of Special Meeting 6MIGENIX Corporate Update and Requisition of Special Meeting 7MIGENIX Corporate Update and Requisition of Special Meeting 8
... Todays research and biologic production demands ... guesswork to confirming viable cell populations. Therefore, ... cells must be determined accurately and precisely. ... an automatic and cost effective means to ...
... SureLINK Bioconjugation Kit provides a powerful yet ... and nuceleic acids. The kit provides the ... reagents for quantifying conjugation efficiencies. It enables ... biotin and other tags with a variety ...
... the sensitivity and versatility you expect from ... counting with selected photomultipliers ensure superior sensitivity ... with up to 2 reagent injectors the ... assays as well as other luminescence applications ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Biology Products: