Navigation Links
Genomes of identical twins reveal epigenetic changes that may play role in lupus
Date:12/21/2009

despread changes in DNA methylation status at a significant number of genes. Dr. Esteban Ballestar, senior author of the study, noted that this is the largest number of genes exhibiting DNA methylation changes observed in an autoimmune disease to date, and includes genes previously implicated in SLE pathogenesis. Importantly, Ballestar's team found that a significant number of the novel differentially methylated genes are related to multiple immune system functions and are potentially linked to SLE.

"Our study suggests that the effect of the environment or differences in lifestyle may leave a molecular mark in key genes for immune function that contributes to the differential onset of the disease in twins," Ballestar said. Most studies of DNA methylation and human disease have been in the context of cancer research, Ballestar noted, and he hopes that this work will attract more researchers to also investigate DNA methylation alterations in autoimmune disease and other disorders for the development of therapies.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. International team compares 12 fruit fly genomes
2. Scientists decode genomes of diverse TB isolates
3. Latest Integrated Microbial Genomes data management system update release
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
6. New computational technique allows comparison of whole genomes as easily as whole books
7. After dinosaurs, mammals rise but their genomes get smaller
8. Genomes reveal bacterial lifestyles: Research
9. Genomes of 2 popular research strains of E. coli sequenced
10. Singapore scientists join international study of 10,000 vertebrates genomes
11. Identical twins not as identical as believed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
(Date:1/22/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... on the recent success of the Wocket™ smart wallet at CES 2015 ... wallet was named as one of the "11 Hot Products at CES" ... Launched At CES So Far" by Newseveryday.com and "The top 10 gadgets ...
(Date:1/22/2015)... , Jan. 22, 2015   EyeLock, Inc. , a ... has appointed Steve Gerber to the new role ... be responsible for leading development of mobile platforms and wearable ... of success and innovation in the semiconductor industry to his ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... of human societies in Asia have been linked to ... A new paper published online today in the ... monsoon climate over longer time scales also influenced the ... The climate over much of Asia is dominated ...
... contemporary art, historical artifacts, and large-scale models, Molecules ... altered modern life. In conjunction with this fascinating ... the science in everyday experiences and the promise ... Molecules That Matter lecture series features a range ...
... $500 million biofuels research partnership that created the ... of Distinction" by the Licensing Executives Society, an ... The annual Deal of Distinction awards, announced ... licensing. According to the society, the awards recognize ...
Cached Biology News:Sedimentary records link Himalayan erosion rates and monsoon intensity through time 2Sedimentary records link Himalayan erosion rates and monsoon intensity through time 3Energy Biosciences Institue named "Deal of Distinction" by tech-transfer group 2
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... been honored for its commitment to sustainability with inclusion on ... is the highest ranked healthcare equipment company among the Corporate ... the World Economic Forum at Davos, Switzerland ...
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer Experience ... Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and ... of revenues. , Browse 152 market data tables, ... on “Service Quality Management (SQM) and Telco Customer Experience ...
(Date:12/24/2014)... , Dec. 24, 2014  Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that the Company closed ... Oracle Investment Management, Jack W. Schuler , ... proceeds were $10.5 million, before offering expenses.  The ...
(Date:12/24/2014)... Missouri (PRWEB) December 23, 2014 GMO corn ... company, Syngenta, are in the process of being consolidated in ... is In Re: Syngenta AG MIR 162 Corn Litigation, MDL ... of Kansas. , Management of the Syngenta GMO corn multidistrict ...
Breaking Biology Technology:Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... Wisconsin-Madison faculty and staff interested in launching technology-based businesses ... through the process of taking a good idea to ... at the University of Wisconsin-Madison," is now available as ... UW-Madison Office of Corporate Relations (OCR). , ,The new ...
... big ideas into even bigger businesses is the theme ... be held June 1-2 in Milwaukee, conference organizers announced ... entrepreneurial growth in Wisconsin. , ,We must create an ... our economy forward and create well-paying jobs, said Kelly ...
... not a jobless recovery, after all. Perhaps its just a matter ... figures for March showed the addition of 308,000 jobs to the ... average month to keep pace with growth in the labor force. ... but the first time in many months that it expanded well ...
Cached Biology Technology:New guide offers assistance to UW-Madison entrepreneurs 2Entrepreneurs Conference to focus on strategies, tools and culture 2In our changing economy, just-in-time employment masks job creation numbers 2In our changing economy, just-in-time employment masks job creation numbers 3
Ready-to-use solution....
... Conjugated peptides or recombinant proteins are ... produce antibodies in 2 rabbits. pre-immune and ... test until the titer reaches 1:4,000 Western ... Protein G purification Antibodies are eluted using ...
...
...
Biology Products: