Navigation Links
Genomes of cholera bacteria from Haiti confirm epidemic originated from single source
Date:7/1/2013

October 2010, but because of the nature of PFGE, the significance of those changes was not known. Were the changes meaningful? Were the bacteria gaining or losing genes that could impact the course of disease? Did they gain genes from other bacteria in the environment? Are their genomes rearranged? The answers could make a difference in the severity of future outbreaks.

The authors of the study in mBio set out to study in greater detail how V. cholerae may have evolved since its introduction to the island nation, and whether it has acquired genes that bestow new abilities. They sequenced the genomes of 23 different V. cholerae isolates from Haiti that represent multiple PFGE "fingerprint" patterns and were taken from a variety of locations and at various time points during the epidemic.

When compared with the genome sequences of V. cholerae strains from around the world, the Haiti isolates and three Nepal isolates are tightly related, forming a monophyletic group to which no other genome sequences belong.

This result indicates that "Nepalese isolates are the closest relatives to the Haiti strain identified to date, even when placed into a phylogeny with a larger collection of isolates representing recent cholera epidemics," write the authors. This means that the outbreak originated from a single introduction of bacteria, and PFGE variants arose from gradual evolution of the organisms, not from any secondary introduction.

The Haiti strains also have a limited ability to acquire new genes through the process of transformation, by which genetic material is picked up from other bacteria or from the environment. There is some evidence that transformation is an important mechanism for bacteria to acquire the necessary abilities to adapt to a particular environment, so the fact that the Haiti strains are deficient in this respect raises the question of whether they will be able to adapt to life in Haiti or
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Athletic frogs have faster-changing genomes
2. Researchers announce GenomeSpace environment to connect genomic tools
3. Differences in the genomes of related plant pathogens
4. Thirty teams compete to interpret three families genomes
5. The first goat genome sets a good example for facilitating de novo assembly of large genomes
6. Sequencing hundreds of chloroplast genomes now possible
7. FASEB SRC announces conference registration open for: Mobile DNA in Mammalian Genomes
8. Mitochondrial mutations: When the cells 2 genomes collide
9. BGI Tech develops novel Ultra-Deep de novo assembly solution for heterozygous genomes
10. Genomes for science, genomes for life, and genomes for you and me
11. Haiti cholera mutations could lead to more severe disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... , April 1, 2015   Medisafe ™, the ... users across iOS and Android ... integrating biofeedback into the platform to allow patients to ... For the first time, patients will be able to ... dose impacts important biometrics, such as glucose levels and ...
(Date:3/31/2015)... --  Guidepoint , a leading global research services firm, ... TRACKER, part of the Guidepoint TRACKER suite ... device and therapeutics markets. The Post-Surgical Pain Management TRACKER ... share, and adoption rates across three major modalities used ... The Post-Surgical Pain Management TRACKER will provide length ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... hard to come by, a University of Central Florida and ... National Institutes of Health highly competitive grants for hemophilia research. ... is aimed at determining whether a green technique pioneered at ... The second grant worth $2 million for four years is ...
... The Newark College of Engineering (NCE) at NJIT has been ... one of 20 universities and colleges across the nation in ... programs. This selection is the culmination of a ... Associate Dean Lisa Axe. Currently, some 43 percent ...
... out of the lab for a test drive with ... new way to develop possible future scenarios. James ... Center for Systems Integration and Sustainability (CSIS) and now ... London, has paired the relatively new use of agent-based ...
Cached Biology News:Hemophilia research gets NIH boost to a tune of $5.5 million 2Hemophilia research gets NIH boost to a tune of $5.5 million 3NSF funds NJIT's participation in program to retain engineering students 2Engaging land-use stakeholders is model behavior 2
(Date:4/24/2015)... 2015 PAREXEL International Corporation (NASDAQ: PRXL ... that Partnerships in Clinical Trials named PAREXEL,s Drew ... Innovator of the Year.  The honor recognizes Mr. Garty,s ... Perceptive MyTrials ® Data-Driven Monitoring solution. ... 2015 Partnership Awards in Boston , ...
(Date:4/23/2015)... April 23, 2015 /CNW/ - A new and innovative ... from North America,s largest ... won Silver in the "Sustainability, service" category of ... Brandcheck "Competitor Comparison" is a service that scores ... and Global peers. This benchmarking process shows clients ...
(Date:4/23/2015)... San Jose, California (PRWEB) April 23, 2015 ... – Predictive diagnostics refer to a series of ... such as cystic fibrosis, Lou Gehrig's disease, Huntington's ... beneficial in examining the gene composition and interaction ... of the disease as well as the response ...
(Date:4/23/2015)... Irvine, CA (PRWEB) April 23, 2015 ... research leader in Personalized Medicine, is excited to ... Medication Response profile . This profile assesses 62 ... and provide dosing information for commonly prescribed non-opioid ... gabapentin (brand name Neurontin), alprazolam (brand name Xanax) ...
Breaking Biology Technology:PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3
... Palatin Technologies,Inc. (Amex: PTN ) will announce ... 9, 2007 before the open of the U.S. financial,markets. ... live audio webcast,hosted by Palatin,s executive management team on ... of operations in greater detail and provide,an update on ...
... 5 Exelixis,Inc. (Nasdaq: EXEL ) today ... 30, 2007. Revenues for the quarter ended ... million for the comparable period in 2006. The ... due to revenue recognition,associated with new collaboration agreements ...
... patients in over 30 states on ... options since 1997, DEERFIELD, Ill., Nov. 5 ... Kidney Patient,Educator (KPE) program, an ambitious project that has ... treatment options to,nearly 80,000 kidney disease patients in over ...
Cached Biology Technology:Palatin Technologies to Report Fiscal Year 2008 First Quarter Results; Teleconference and Webcast on November 9, 2007 2Exelixis Announces Third Quarter 2007 Financial Results and Business Update 2Exelixis Announces Third Quarter 2007 Financial Results and Business Update 3Exelixis Announces Third Quarter 2007 Financial Results and Business Update 4Exelixis Announces Third Quarter 2007 Financial Results and Business Update 5Exelixis Announces Third Quarter 2007 Financial Results and Business Update 6Exelixis Announces Third Quarter 2007 Financial Results and Business Update 7Exelixis Announces Third Quarter 2007 Financial Results and Business Update 8Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 2Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 3Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 4
Adjustable tilt angle 0 to 20 Adjustable speed of 3-25 RPM Load capacity: 2.7 kg (6 lbs.) Ambient temperature range 4C to 65C Low voltage power is supplied by wall mount transformer...
Request Info...
... the rapid isolation of DNA from high melt ... the spin filter, centrifuge for 3 minutes, and ... is no need to melt agarose or use ... be used for buffer exchange, primer removal from ...
Request Info...
Biology Products: