Navigation Links
Genomes of cholera bacteria from Haiti confirm epidemic originated from single source
Date:7/1/2013

October 2010, but because of the nature of PFGE, the significance of those changes was not known. Were the changes meaningful? Were the bacteria gaining or losing genes that could impact the course of disease? Did they gain genes from other bacteria in the environment? Are their genomes rearranged? The answers could make a difference in the severity of future outbreaks.

The authors of the study in mBio set out to study in greater detail how V. cholerae may have evolved since its introduction to the island nation, and whether it has acquired genes that bestow new abilities. They sequenced the genomes of 23 different V. cholerae isolates from Haiti that represent multiple PFGE "fingerprint" patterns and were taken from a variety of locations and at various time points during the epidemic.

When compared with the genome sequences of V. cholerae strains from around the world, the Haiti isolates and three Nepal isolates are tightly related, forming a monophyletic group to which no other genome sequences belong.

This result indicates that "Nepalese isolates are the closest relatives to the Haiti strain identified to date, even when placed into a phylogeny with a larger collection of isolates representing recent cholera epidemics," write the authors. This means that the outbreak originated from a single introduction of bacteria, and PFGE variants arose from gradual evolution of the organisms, not from any secondary introduction.

The Haiti strains also have a limited ability to acquire new genes through the process of transformation, by which genetic material is picked up from other bacteria or from the environment. There is some evidence that transformation is an important mechanism for bacteria to acquire the necessary abilities to adapt to a particular environment, so the fact that the Haiti strains are deficient in this respect raises the question of whether they will be able to adapt to life in Haiti or
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Athletic frogs have faster-changing genomes
2. Researchers announce GenomeSpace environment to connect genomic tools
3. Differences in the genomes of related plant pathogens
4. Thirty teams compete to interpret three families genomes
5. The first goat genome sets a good example for facilitating de novo assembly of large genomes
6. Sequencing hundreds of chloroplast genomes now possible
7. FASEB SRC announces conference registration open for: Mobile DNA in Mammalian Genomes
8. Mitochondrial mutations: When the cells 2 genomes collide
9. BGI Tech develops novel Ultra-Deep de novo assembly solution for heterozygous genomes
10. Genomes for science, genomes for life, and genomes for you and me
11. Haiti cholera mutations could lead to more severe disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
(Date:7/23/2015)... (NASDAQ: AWRE ), a leading supplier of biometrics software ... ended June 30, 2015.  Revenue for the ... 33% compared to $6.8 million in the same quarter last ... $0.3 million, or $0.01 per diluted share, which compared to ... period a year ago.  Lower revenue and ...
(Date:7/21/2015)... OXFORD, Connecticut , July 21, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... the Wocket® smart wallet, announces that it has ... Tokenization System and Method. This ... that not only authorizes an account, but also ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4
... yourself with a blanket to stave off the shivers? ... help alleviate shivering in patients who have been cooled ... or dangerously high fevers are often cooled to reduce ... aid healing. Unfortunately, cooling induces a natural and familiar ...
... Tiny flying machines can be used for everything ... simply making smaller versions of planes and helicopters ... Carolina State University are mimicking nature,s small flyers ... maneuverability and performance. Small flyers, or micro-aerial ...
... from the British Antarctic Survey have collected individuals from a ... subjected them to increasing levels of water temperature to learn ... that they are likely to experience in the future. The ... really close to their upper temperature range, and that further ...
Cached Biology News:Robo-bats with metal muscles may be next generation of remote control flyers 2
(Date:7/30/2015)... New York, NY (PRWEB) , ... July 30, 2015 , ... As part of its ... raw material and technical service business units, Whitehouse Laboratories is pleased ... facility will be adjacent to the Container Center of Excellence and will be strictly dedicated ...
(Date:7/29/2015)... , July 30, 2015 ... la santé, publie ses résultats pour le premier ... commente les résultats. Visionner l,interview ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Au sommaire de ... - Moteurs de croissance - ...
(Date:7/29/2015)... Asia-Pacific / Japan (Q2 2015: +14% CER ... 2015 on high-single-digit growth in China , as well as ... . Europe / Middle East ... of sales) showed gains in Germany , Turkey ... 2015: +4% CER / 49% of sales) grew 11%, excluding U.S. HPV sales, ...
(Date:7/29/2015)... , July 29, 2015  AsureQuality and ... molecular testing for applications in food and primary ... battery powered real-time PCR device, the Freedom4. ... right through to the supermarket shelf for producers, ... includes involvement in animal disease control and pest ...
Breaking Biology Technology:Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
... for 15 minutes, couldn't imagine the influence the Internet, blogging, social ... these tools, everyone can have their 15 minutes - but just ... is about all anyone has time for these days, at least ... reminded of this after coming back from a near three-week holiday ...
... the lead cancer drug candidate of Madison's Quintessence Biosciences ... Food and Drug Aministration for being tested on cancer ... meeting of the American Association for Cancer Research , ... scale and applied in safe doses, the company announced. , ...
... Madison, Wis . - Mithridion, Inc ., a biopharmaceutical ... of Alzheimer's disease, has closed an additional $1.2 million of ... , ,The latest round of funding brings the total equity ... above the company's initial funding target. Mithridion will use the ...
Cached Biology Technology:On the Web, attention spans shrink, the need for value rises 2On the Web, attention spans shrink, the need for value rises 3Quintessence Biosciences advances cancer drug 2Alzheimer's drug developer lands $1.2M in venture funding 2Alzheimer's drug developer lands $1.2M in venture funding 3
Peptide-affinity Purified Polyclonal Antibody to Histamine H2 Receptor...
Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
Monoclonal Antibody to GLP Immunogen: Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3)...
...
Biology Products: