Navigation Links
Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
Date:7/31/2011

Researchers at the RIKEN Center for Genomic Medicine (CGM), together with colleagues at Kyoto University, Tsukuba University, Harvard University, and other medical institutions have identified three new loci associated with susceptibility to adult asthma in the Japanese population. The findings appear in Nature Genetics and derive from a genome-wide study of 4836 Japanese individuals.

Around the world, hundreds of millions of people suffer from bronchial asthma, a chronic inflammatory disease characterized by symptoms of wheezing, shortness of breath and coughing. In adults, death caused by asthma is by far most prevalent among the elderly, with 90% of cases afflicting those aged 60 or older. Treatment techniques remain ineffective in severe cases, resulting in chronic suffering and a heavy economic burden for patients and their families.

To clarify the genetic origins of adult asthma, the research group conducted a genome-wide association study on 1532 adult patients and 3,304 controls. Among a total of roughly 460,000 genetic variants (called Single Nucleotide Polymorphisms or SNPs), the group identified five genetic regions associated with susceptibility to adult asthma, three of which had not previously been connected to the disease. The associations were confirmed in a separate replication study on a population of 5,639 patients and 24,608 controls.

The regions identified contain SNPs previously associated with the FEV1/FVC ratio, a calculated ratio crucial to the diagnosis of obstructive and restrictive diseases, as well as numerous genes that play a role in immunity response to infection and inflammation. One of these genes encodes the protein thymic stromal lymphopoietin (TSLP), which plays a critical role in sensing environmental agents and triggering immune response. The SNP in the region containing this gene was reproduced in a separate study on non-Hispanic individuals of European ancestry, suggesting that region may be a common hereditary factor for asthma across ethnic groups.

Together, the findings of this extensive study shed light on the genetic factors contributing to asthma susceptibility, pointing the way to more effective treatment techniques and a better future for millions of asthma sufferers around the world.


'/>"/>

Contact: RIKEN Global Relations Office
koho@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Related biology news :

1. Singapore scientists first to perform genome-wide study of human stem cells
2. Researchers gain genome-wide insights into patterns of the worlds human population structures
3. New tool for genome-wide association studies
4. Ongoing global biodiversity loss unstoppable with protected areas alone: Study
5. New study outlines economic and environmental benefits to reducing nitrogen pollution
6. Toucans wearing GPS backpacks help Smithsonian scientists study seed dispersal
7. Study suggests weight loss from gastric bypass may be partly due to dietary fat aversion
8. Study: Climate change to increase Yellowstone wildfires dramatically
9. UCI-led butterfly study sheds light on convergent evolution
10. As new data wave begins, a gene study in one disease discovers mutations in an unrelated disease
11. First global study of real-world circumcision rollout conducted over 3-year period in South Africa amongst 110,000 adults shows a marked reduction (>60 percent) of HIV acquisition among circumcised adult men
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
(Date:3/18/2016)... --> --> Competitive Landscape ... Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which is ... & security companies in the border security market and ...
(Date:3/14/2016)... -- NXTD ) ("NXT-ID" or the "Company"), a ... airing of a new series of commercials on Time Warner ... st .  The commercials will air on Bloomberg TV, Fox ... Street show. --> NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ...
(Date:3/10/2016)... -- --> --> ... Access Management Market by Component (Provisioning, Directory Services, Password ... Size, by Deployment, by Vertical, and by Region - ... is estimated to grow from USD 7.20 Billion in ... Compound Annual Growth Rate (CAGR) of 12.2% during the ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... , ... May 02, 2016 , ... StarNet Communications Corp, ... announced the addition of three Secure Remote Desktop modules to its flagship X-Win32 PC ... from Linux and Unix servers to the user’s PC over encrypted SSH. , Traditionally, ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... medical devices used in spinal surgical procedures, today announced the completion of a ... value proposition for current and future customers and partners. Kohlberg & Company, ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intelligent Implant Systems announced today that the two-level ... sale in the United States. These components expand the capabilities of the system ... sales beginning in October of 2015, the company has seen significant sales growth in ...
(Date:4/28/2016)... Hill, Conn. (PRWEB) , ... April 28, 2016 ... ... of financing and ongoing support for Connecticut's innovative, growing companies, today announced the ... digital health and financial technology (fintech) companies. , “VentureClash looks to ...
Breaking Biology Technology: