Navigation Links
Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
Date:7/31/2011

Researchers at the RIKEN Center for Genomic Medicine (CGM), together with colleagues at Kyoto University, Tsukuba University, Harvard University, and other medical institutions have identified three new loci associated with susceptibility to adult asthma in the Japanese population. The findings appear in Nature Genetics and derive from a genome-wide study of 4836 Japanese individuals.

Around the world, hundreds of millions of people suffer from bronchial asthma, a chronic inflammatory disease characterized by symptoms of wheezing, shortness of breath and coughing. In adults, death caused by asthma is by far most prevalent among the elderly, with 90% of cases afflicting those aged 60 or older. Treatment techniques remain ineffective in severe cases, resulting in chronic suffering and a heavy economic burden for patients and their families.

To clarify the genetic origins of adult asthma, the research group conducted a genome-wide association study on 1532 adult patients and 3,304 controls. Among a total of roughly 460,000 genetic variants (called Single Nucleotide Polymorphisms or SNPs), the group identified five genetic regions associated with susceptibility to adult asthma, three of which had not previously been connected to the disease. The associations were confirmed in a separate replication study on a population of 5,639 patients and 24,608 controls.

The regions identified contain SNPs previously associated with the FEV1/FVC ratio, a calculated ratio crucial to the diagnosis of obstructive and restrictive diseases, as well as numerous genes that play a role in immunity response to infection and inflammation. One of these genes encodes the protein thymic stromal lymphopoietin (TSLP), which plays a critical role in sensing environmental agents and triggering immune response. The SNP in the region containing this gene was reproduced in a separate study on non-Hispanic individuals of European ancestry, suggesting that regio
'/>"/>

Contact: RIKEN Global Relations Office
koho@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Singapore scientists first to perform genome-wide study of human stem cells
2. Researchers gain genome-wide insights into patterns of the worlds human population structures
3. New tool for genome-wide association studies
4. Ongoing global biodiversity loss unstoppable with protected areas alone: Study
5. New study outlines economic and environmental benefits to reducing nitrogen pollution
6. Toucans wearing GPS backpacks help Smithsonian scientists study seed dispersal
7. Study suggests weight loss from gastric bypass may be partly due to dietary fat aversion
8. Study: Climate change to increase Yellowstone wildfires dramatically
9. UCI-led butterfly study sheds light on convergent evolution
10. As new data wave begins, a gene study in one disease discovers mutations in an unrelated disease
11. First global study of real-world circumcision rollout conducted over 3-year period in South Africa amongst 110,000 adults shows a marked reduction (>60 percent) of HIV acquisition among circumcised adult men
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
(Date:12/22/2014)... 2014 Research and Markets ... of the "The Global Watermarking and ... http://photos.prnewswire.com/prnh/20130307/600769 ... of the global digital media watermarking and ... monitor piracy by securely and invisibly embedding ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ... team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research ... announced the addition of the "Global Chemical ... http://photos.prnewswire.com/prnh/20130307/600769 ... is the increasing demand for medical sensors in ... patient data for quick and correct diagnosis during ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... to expand at a record pace with the addition of ... provides data on nearly half of all described species, with ... the International Union for the Conservation of Nature (IUCN) and ... In the four years since its first release, EOL ...
... Durham, NC The toothiest prehistoric predators also had beefier ... may come to mind, but these extinct cats weren,t the ... also known as nimravids and their catlike cousins, ... of these mammal groups lived millions of years before cats ...
... science have been discovered on the seafloor near Antarctica, ... The discoveries, made by teams led by the ... Survey, include new species of yeti crab, starfish, barnacles, ... first time, researchers have used a Remotely Operated Vehicle ...
Cached Biology News:The Encyclopedia of Life expanding at a record pace 2Prehistoric predators with supersized teeth had beefier arm bones 2Prehistoric predators with supersized teeth had beefier arm bones 3'Lost world' discovered around Antarctic vents 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... , NEW YORK, Nov. ... research report is available in its catalogue. , ... Perspective , http://www.reportlinker.com/p0164375/Biotechnology-Reagents---A-Global-Market-Perspective.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire ... chemical compounds used in a range of biotech ...
... , MONROVIA, Calif. and HANGZHOU, China, Nov. 18 ... "Company") (OTC Bulletin Board: NIUS), a leading U.S.-based biotech company ... announced that the Company,s popular Gummy Bear products will be ... has entered into a one year distribution contract with Hainan ...
... AMSTERDAM, November 18 , ... Heart,Association , Amsterdam Molecular Therapeutics (EuroNext Amsterdam: ... its non-audited business,update in compliance with the EU transparency directive. This ... 2009. , Q3 2009 Highlights, ...
Cached Biology Technology:Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 2Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 3Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 4Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 5Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 6Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 7Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 8Niusule Expands Geographic Footprint in China 2Niusule Expands Geographic Footprint in China 3AMT Provides Business Update for the Third Quarter 2009 2AMT Provides Business Update for the Third Quarter 2009 3AMT Provides Business Update for the Third Quarter 2009 4
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Phosphorylcholine hapten is conjugated to BSA protein by use of p-diazonium phenylphosphorylcholine....
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
Blue Standard is 3-cyano-7-hydroxycoumarin....
Biology Products: