Navigation Links
Genome-wide hunts reveal new regulators of blood pressure
Date:9/11/2011

A study involving more than 200,000 people worldwide has identified 29 DNA sequence variations in locations across the human genome that influence blood pressure. These genes, whose sequence changes are associated with alterations in blood pressure and are linked to heart disease and stroke, were found with the help of decades' worth of population data that were pooled and analyzed by a large international consortium, including Johns Hopkins researchers.

Among the findings was evidence that the same common genetic variants associated with hypertension in European populations also are frequently found in individuals of Asian and African ancestry, according to the report that appears September 11 in Nature.

"A genetic risk score that adds up the effects of all of these variants shows that the more of these variants an individual has, the greater are his or her chances of having hypertension, left ventricular wall thickness, stroke and coronary artery disease," says Aravinda Chakravarti, Ph.D., a professor of medicine, pediatrics and molecular biology and genetics at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, and one of the lead authors.

The individuals whose genomes were analyzed for this study had their blood pressures recorded when they originally entered other long-term cardiovascular research studies, and scientists used these measures to assess the predictive value of the genes and blood pressures in terms of the subjects' current cardiovascular status.

This genome-wide association study focused on systolic and diastolic blood pressures: measures of the maximum and minimum pressures exerted on the arteries. However, in a related genome-wide investigation reported September 11 in Nature Genetics, the same scientists found an additional six locations across the genome where variants affect blood pressure by focusing on two other relevant measures: pulse pressure (the difference
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New tool for genome-wide association studies
2. Researchers gain genome-wide insights into patterns of the worlds human population structures
3. Singapore scientists first to perform genome-wide study of human stem cells
4. Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
5. National Cancer Institute renews Cancer Center designation for Huntsman Cancer Institute
6. Iowa State, Ames Lab researcher hunts for green catalysts
7. £2 million study to reveal workings of dementia genes
8. Study reveals homeowner perceptions in fire-prone areas
9. Study reveals specific gene in adolescent men with delinquent peers
10. 6 environmental research studies reveal critical health risks from plastic
11. Revealing the evolutionary history of threatened sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, ... devices with specialties in single use solutions, headquartered in ... MedConx, Inc. (a California corporation with ... San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility in ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/23/2015)... 2015 Research and ... the "Body-Worn Temperature Sensors Market - Global ... 2014 - 2020" report to their offering. ... the global body-worn temperature sensors market. The global ... the basis of types, care setting, patient demographic, ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
... #1 FOR IMMEDIATE RELEASE Identifying abnormal protein ... Research Researchers in Massachusetts are reporting an ... the biochemical changes that occur inside the eyes of ... of vision loss and blindness in adults. In a ...
... already for its role in schizophrenia has been ... a report in todays advance on-line issue of Nature. ... Center (BIDMC), the study further suggests that a steroid ... and therapeutic supplement for the treatment of this dangerous ...
... straightforward migration to EAC ePassport technology, DALLAS, ... Inc. (Nasdaq: ENTU ) will provide its ... help authenticate sensitive,biometric information stored on machine readable ... which will be available to nearly 23 million,citizens ...
Cached Biology News:American Chemical Society’s Weekly PressPac -- May 7, 2008 2American Chemical Society’s Weekly PressPac -- May 7, 2008 3American Chemical Society’s Weekly PressPac -- May 7, 2008 4American Chemical Society’s Weekly PressPac -- May 7, 2008 5American Chemical Society’s Weekly PressPac -- May 7, 2008 6American Chemical Society’s Weekly PressPac -- May 7, 2008 7American Chemical Society’s Weekly PressPac -- May 7, 2008 8A new gene trigger for pregnancy disorder identified 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 3
(Date:7/1/2015)... ... July 01, 2015 , ... A newly launched business plan contest will ... barriers to innovation in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 ... US$15,000 and a period of expert mentorship from a senior industry figure drawn from ...
(Date:7/1/2015)... , July 1, 2015  UCB, a multinational ... a global leader in designing, transforming, and running ... Award in recognition of their close collaboration in ... UCB,s global business services (GBS) finance organization. ... and clients that work together effectively to embrace ...
(Date:6/30/2015)... Clara CA (PRWEB) , ... June 30, 2015 ... ... microscopy (AFM) is hosting a webinar to provide advanced scientific research into new ... science, bio science and energy. Touted as 'the wonder material of the ...
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome and ... insights on mechanics of fecal microbiota transplantation in C. difficile patients. , SAN ... of patients undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium difficile ...
Breaking Biology Technology:Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3
... MADISON If you asked Wisconsin citizens what they ... the past year or so, the answers would likely ... bills dealing with religion, concealed weapons and same-sex marriage. ... so-called three Gs werent the biggest story of the ...
... , based in Green Bay, has announced a ... reach out to creative agencies and their clients. , ... designers, project managers and clients. It is intended as ... documents and files, the company said. , ,"Typically, Inspire ...
... of PR account executives when one woman asked a question that ... my opinion on the proliferation of mobile devices, she asked if ... question a lot, in one form or another, but on this ... the very earliest days of a new age of computing, I ...
Cached Biology Technology:Despite the three Gs, the Wisconsin Legislature had a productive session 2Despite the three Gs, the Wisconsin Legislature had a productive session 3Wisconsin startup delivers project management relief to creative firms and ad agencies 2The age of human computing? 2The age of human computing? 3
... The super cooling coil, ... for native enzyme, high-intensity, and ... performed with the Trans-Blot cell. ... coil requires connection to an ...
Criterion staining and blotting trays are plastic trays designed for staining one or two Criterion gels or performing western blot detection. The trays have a working capacity of up to 500 ml. Suppli...
... wide range of next-generation features into a ... standard for flexible laboratory solutions. It puts ... pipetting, dilution, dispensing, and integrations into ... and flexible as it is efficient and ...
... Biomek FX provides complete solutions ... With 96-, 384-, and ... in either single or dual ... offers maximum speed and flexibility ...
Biology Products: