Navigation Links
Genome-wide hunts reveal new regulators of blood pressure
Date:9/11/2011

A study involving more than 200,000 people worldwide has identified 29 DNA sequence variations in locations across the human genome that influence blood pressure. These genes, whose sequence changes are associated with alterations in blood pressure and are linked to heart disease and stroke, were found with the help of decades' worth of population data that were pooled and analyzed by a large international consortium, including Johns Hopkins researchers.

Among the findings was evidence that the same common genetic variants associated with hypertension in European populations also are frequently found in individuals of Asian and African ancestry, according to the report that appears September 11 in Nature.

"A genetic risk score that adds up the effects of all of these variants shows that the more of these variants an individual has, the greater are his or her chances of having hypertension, left ventricular wall thickness, stroke and coronary artery disease," says Aravinda Chakravarti, Ph.D., a professor of medicine, pediatrics and molecular biology and genetics at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, and one of the lead authors.

The individuals whose genomes were analyzed for this study had their blood pressures recorded when they originally entered other long-term cardiovascular research studies, and scientists used these measures to assess the predictive value of the genes and blood pressures in terms of the subjects' current cardiovascular status.

This genome-wide association study focused on systolic and diastolic blood pressures: measures of the maximum and minimum pressures exerted on the arteries. However, in a related genome-wide investigation reported September 11 in Nature Genetics, the same scientists found an additional six locations across the genome where variants affect blood pressure by focusing on two other relevant measures: pulse pressure (the difference
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New tool for genome-wide association studies
2. Researchers gain genome-wide insights into patterns of the worlds human population structures
3. Singapore scientists first to perform genome-wide study of human stem cells
4. Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
5. National Cancer Institute renews Cancer Center designation for Huntsman Cancer Institute
6. Iowa State, Ames Lab researcher hunts for green catalysts
7. £2 million study to reveal workings of dementia genes
8. Study reveals homeowner perceptions in fire-prone areas
9. Study reveals specific gene in adolescent men with delinquent peers
10. 6 environmental research studies reveal critical health risks from plastic
11. Revealing the evolutionary history of threatened sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... N.C. – Like discriminating thieves, prostate cancer tumors scavenge ... the body. But such avarice may be a fatal ... a way to kill prostate cancer cells by delivering ... selectively destroys the diseased cells brimming with the mineral, ... uses two drugs already commercially available for other uses, ...
(Date:10/14/2014)... 14, 2014)—It,s been millions of years since T. ... led by Ohio University scientists is breathing life back ... through dinosaur snouts. The research has important implications for ... but to enhance the sense of smell and cool ... said Ohio University doctoral student Jason Bourke, lead author ...
(Date:10/14/2014)... to produce enough food to feed the world in ... of the United Nations predicts that food production must ... a growing global population, and plants are one major ... Plants—grains, cereals, fruits, vegetables, and more—feed humans directly and ... into our knowledge of how plants work to develop ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... multi-disciplinary synthesis just published in Environmental Reviews ... development to address significant environmental, social and economic impacts ... "Effects of climate change on the distribution of invasive ... change prediction in a warming world" is the collaborative ...
... , The global average surface temperature in 2011 was ... The finding continues a trend in which nine of ... have occurred since the year 2000. NASA,s Goddard ... monitors global surface temperatures on an ongoing basis, released ...
... BioEYES, will be the recipient of the 2012 Viktor ... Biology. BioEYES founders Steve Farber and Jamie Shuda ... upcoming annual meeting of the society in Montreal in ... currently featured in a video on the front page ...
Cached Biology News:Climate change invites alien invaders Is Canada ready? 2NASA finds 2011 ninth-warmest year on record 2
(Date:10/18/2014)... The Asia-Pacific Liquid Crystal on Silicon (LCoS) ... in Asia-Pacific with analysis and forecast of revenue. This ... is expected to reach $380.0 million by 2018, at ... Browse through the TOC of the Asia-Pacific LCoS display ... analysis provided. This also provides a glimpse of the ...
(Date:10/18/2014)... According to a new market research report ... Global Trends & Forecasts up till 2017”, hydraulic fracturing ... This value is expected to increase from $40 billion ... CAGR during the same period. North America is expected ... terms of hydraulic horse power supplied by the year ...
(Date:10/17/2014)... received a $451,781 Air Force Office of Scientific Research ... and nano-scale level that will provide clues for predicting ... and Aerospace Engineering, said the new technology and process ... of an aircraft,s wing., "We,ll be able to determine ... at it on this scale," Huang said. "Certain patterns ...
(Date:10/17/2014)... For the seventh consecutive year, ... in today’s print issue of Science magazine. , ... Survey polled employees in the biotechnology, pharmaceutical and ... Rankings were determined based on responses from ... companies on 23 characteristics, including financial strength, leadership ...
Breaking Biology Technology:The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4UT Arlington project to detect possible damages in aircraft parts early in process 2DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... done and now they,ve done it. What,s more, they did ... U.S. Department of Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley ... the first experimental demonstration of GRIN for gradient index ... a wide range of exotic optics, including superfast computers based ...
... 2011 Amgen (Nasdaq: AMGN ) and ... into a definitive acquisition agreement under which Amgen has ... venture-funded,  biotechnology company headquartered in Woburn, Mass. BioVex is ... Phase 3 clinical development, that may represent a new ...
... (Nasdaq: CEPH ) will hold a public memorial service ... and CEO on February 1, 2011, at 6:00 p.m. at The ... Dr. Baldino founded Cephalon in 1987 and led the ... ten biotechnology companies in the world. He was a recognized pioneer ...
Cached Biology Technology:GRIN plasmonics 2GRIN plasmonics 3GRIN plasmonics 4Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 2Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 3Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 4Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 5Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 6Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 7Cephalon to Hold Public Memorial Service to Celebrate the Life of Company Founder, Frank Baldino, Jr., Ph.D. 2
Glycerokinase; from Bacillus stearothermophilus...
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
... Ascent FL is equipped ... luminometric measurement technologies that ... of advanced features of ... Ascent. Fluoroskan Ascent FL ...
... hydrolytic enzyme that catalyzes the conversion,of ... maltose, maltotriose and,dextrins. The level of ... human,body are of clinical importance,1-3 while ... for industry.4, The EnzChek Amylase Assay ...
Biology Products: