Navigation Links
Genome-wide hunts reveal new regulators of blood pressure
Date:9/11/2011

A study involving more than 200,000 people worldwide has identified 29 DNA sequence variations in locations across the human genome that influence blood pressure. These genes, whose sequence changes are associated with alterations in blood pressure and are linked to heart disease and stroke, were found with the help of decades' worth of population data that were pooled and analyzed by a large international consortium, including Johns Hopkins researchers.

Among the findings was evidence that the same common genetic variants associated with hypertension in European populations also are frequently found in individuals of Asian and African ancestry, according to the report that appears September 11 in Nature.

"A genetic risk score that adds up the effects of all of these variants shows that the more of these variants an individual has, the greater are his or her chances of having hypertension, left ventricular wall thickness, stroke and coronary artery disease," says Aravinda Chakravarti, Ph.D., a professor of medicine, pediatrics and molecular biology and genetics at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, and one of the lead authors.

The individuals whose genomes were analyzed for this study had their blood pressures recorded when they originally entered other long-term cardiovascular research studies, and scientists used these measures to assess the predictive value of the genes and blood pressures in terms of the subjects' current cardiovascular status.

This genome-wide association study focused on systolic and diastolic blood pressures: measures of the maximum and minimum pressures exerted on the arteries. However, in a related genome-wide investigation reported September 11 in Nature Genetics, the same scientists found an additional six locations across the genome where variants affect blood pressure by focusing on two other relevant measures: pulse pressure (the difference
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New tool for genome-wide association studies
2. Researchers gain genome-wide insights into patterns of the worlds human population structures
3. Singapore scientists first to perform genome-wide study of human stem cells
4. Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
5. National Cancer Institute renews Cancer Center designation for Huntsman Cancer Institute
6. Iowa State, Ames Lab researcher hunts for green catalysts
7. £2 million study to reveal workings of dementia genes
8. Study reveals homeowner perceptions in fire-prone areas
9. Study reveals specific gene in adolescent men with delinquent peers
10. 6 environmental research studies reveal critical health risks from plastic
11. Revealing the evolutionary history of threatened sea turtles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... German . ... in order to reproduce? And why are there two sexes ... latest issue of the research journal Molecular Human Reproduction ... Ramm from Bielefeld University Bielefeld has compiled this special issue ... a female to copulate with several males in quick succession ...
(Date:10/16/2014)... and Washington land managers have a new synthesis of ... moist mixed-conifer (MMC) forests in the two states. ... in Eastern Oregon and Washington: A Synthesis of the ... a general technical report published by the U.S. Forest ... to a request from managers for a synthesis of ...
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
Breaking Biology News(10 mins):Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... MANHATTAN, Kan. -- What if you could shut down ... How about hacking a pacemaker and reprogramming it to ... scenes from an espionage film, they are also some ... experts are working to prevent. Eugene Vasserman, assistant ...
... cucumbers and other crops susceptible to infection by downy ... production costs thanks to collaborative research by Clemson University,s ... North Carolina State University. Anthony P. Keinath, professor ... Center in Charleston, recently was awarded a $40,000 USDA ...
... elk,s personality type is a big factor in whether or ... GPS collars on more than 100 male and female elk ... population could be divided into two categories: bold runners and ... moved quickly through the study area and preferred to graze ...
Cached Biology News:Internal relations 2Internal relations 3Internal relations 4Clemson plant pathologist working to raise cucurbit yields, lower production costs 2In elk hunting, success depends on the animal's personality 2
(Date:10/20/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... orders to $5.8 million and provides a good start to Q4.  ... North America and one in the Middle ... at record levels," said Peter Bruijns , President & CEO. ... of Q3 than they have been for any complete year since ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report ... with analysis and forecast of revenue. This market is ... $208 million by 2019, at a Compound Annual Growth ... Browse through the TOC of the Asia-Pacific Speech Analytics ... analysis provided. It also provides a glimpse of the ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... 2012   Led by NUMODA CAPITAL INNOVATIONS, LLC., PINNACLE BIOLOGICS announced ... in a combination of Equity, and Debt Conversion. ... for Pinnacle Biologics. After completing the acquisition of ... Aptalis Pharma early last year, Pinnacle continues the ...
... Jan. 9, 2012 Exagen Diagnostics, Inc., ... and markets proprietary tests for rheumatologists and gastroenterologists, announced ... the diagnosis of lupus (Systemic Lupus Erythematosus). ... SLE and Rule-Out other rheumatic diseases to help establish ...
... Jan. 9, 2012 Chembio Diagnostics, Inc. (OTC.PK: ... and licenses point-of-care diagnostic tests, today announced that Lawrence ... at the Biotech Showcase in San Francisco at approximately ... Wednesday, January 11, 2012.   The conference ...
Cached Biology Technology:Pinnacle Biologics, Inc. Announces the Successful Completion of a Financing Round 2Pinnacle Biologics, Inc. Announces the Successful Completion of a Financing Round 3Exagen Diagnostics Launches Cutting-Edge Lupus Diagnostic 2Chembio Presenting at Biotech Conference 2Chembio Presenting at Biotech Conference 3
Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood basophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Biology Products: