Navigation Links
Genome update defines landscape of breast and colon cancers
Date:10/11/2007

One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers.

Their report, published online in the October 11 issue of Science Express, indicates that while little is known about these less-commonly mutated genes, they can be grouped into clusters according to their pathways.

There are gene mountains represented by those that are frequently altered and have been the focus of cancer research for years, in part because they were the only genes known to contribute to cancer, says Bert Vogelstein, M.D., an investigator at the Howard Hughes Medical Institute and co-director of the Ludwig Center at Johns Hopkins. Now, we can see the whole picture, and it is clear that lower peaks or gene hills are the predominant feature.

In a systematic search of 18,191 genes representing more than 90 percent of the protein-coding genes in the human genome -- about 5,000 more than in the first screen -- the Johns Hopkins scientists found that most cancer-causing gene mutations are quite diverse and can vary from person to person. They found that an average 77 genes are mutated in an individual colon cancer and 81 in breast cancer. Of these, about 15 are likely to contribute to a cancers key characteristics, and most of these genes may be different for each patient.

Fifteen years ago, we said the p53 gene was the most commonly mutated gene in cancer. Its amazing that this is still true, says Kenneth W. Kinzler, Ph.D., professor of oncology at Hopkins Kimmel Cancer Center.

With no more higher-frequency mutations on the horizon, the investigators say that personalized medicines may now focus on the more complicated pathways that link these less-commonly mutated genes.

As an example, the Hopkins
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
3. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
4. Whole genome fine map of rice completed
5. Genome-wide mouse study yields link to human leukemia
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
10. Highly adaptable genome in gut bacterium key to intestinal health
11. Multiple Campylobacter Genomes Sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Professor Steven Chown has been awarded the Scientific ... Excellence in Antarctic Research. , SCAR, an inter-disciplinary ... quality international scientific research in the Antarctic region, ... in the Earth system. The organisation also provides ... System, responsible for governing the region. , The ...
(Date:7/30/2014)... roughly 3,000 pieces is still in its infant stage. ... be of major significance. "Amazingly often, we are findingin ... amber that we found in Baltic amber," explained Bonn ... amber comes from the Baltic Sea region, which is ... are, e.g., the coastal regions of Mecklenburg, Poland and ...
(Date:7/29/2014)... The advanced optical methods and applications for imaging and ... in the neurosciences were the inspiration behind Neurophotonics ... international society for optics and photonics. , The first ... in the United States, and a special section features ... examples of the impact that optics and photonics will ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3
... a scientist with the Oklahoma Medical Research Foundation, has found ... The discovery could have important implications for the treatment of ... findings appear in the April 13 issue of the journal ... go backwards before now," said Gorbsky, who holds the W.H. ...
... produce a substance which prevents the AIDS pathogen HIV from ... of research carried out by scientists at the University of ... years now the hopes for a completely new group of ... 'DCQA'. However, the substance is only available in very small ...
... genetic cause in up to 80 percent of cases, ... nearly 12,000 twin pairs. , The study appears in ... a journal of the American Medical Association. , Margaret ... Letters, Arts, and Sciences, led an international team of ...
Cached Biology News:Rewind, please: Nature paper shows that cell division is reversible 2AIDS drug from sunflowers 2AIDS drug from sunflowers 3Alzheimer's found to be mostly genetic 2
(Date:7/30/2014)... While administrative claims and other ... for a relatively long period of time, there ... use of these ‘big data’ for comparisons of ... today’s powerful computer technology with the plethora of ... holds significant promise for identifying optimal interventions for ...
(Date:7/30/2014)... July 30, 2014. Applied DNA Sciences, ... provides DNA-based authentication and security solutions and services, has ... Life Sciences, a newly created position, with a starting ... lead APDN’s drive to build its business in pharmaceuticals ... customers, provide guidance to APDN’s R&D efforts, and apply ...
(Date:7/30/2014)... JUPITER, Fla. , July 30, 2014 /PRNewswire/ ... global biotechnology company whose patented and proprietary technologies ... enzymes and other proteins for the bioenergy, bio-based ... the appointment of Thomas "Tom" Dubinski as Vice ... responsible for leading the financial and information technology ...
(Date:7/30/2014)... NCERC at Southern Illinois University Edwardsville ... on corn stover pretreatment methods at a U.S. ... D.C. , “Arun’s selection for presentation at ... to the success of our postdoctoral fellowship program,” ... foresight and vision of SIUE and the Illinois ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 3Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3
... coverage and megabase capacity for the next generation ... febit today announced the official ... In several biomedical studies of early access customers ... factors and deep sequencing coverage for a broad ...
... debuts PAKSCAN, a new-look Pharma-packaging leak tester machine for medical pouches ... ... Ireland (PRWEB) March 16, 2009 -- A leak tester ... by Northern Irish company, sepha makes its U.S. market ...
... Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, ... approval for PROMETHEUS(R) IBS Diagnostic, the first and only ... novel test incorporates 10 biomarkers, two of which are ... diagnose patients with IBS."One out of five Americans has ...
Cached Biology Technology:Automated Sequence Capture for Next-Generation Sequencing Paves the Way for Personalized Medicine 2Automated Sequence Capture for Next-Generation Sequencing Paves the Way for Personalized Medicine 3U.S. Distributor Debut for PAKSCAN - a Pouch & Sachet Leak Tester Machine from Ireland-based Sepha Ltd. 2U.S. Distributor Debut for PAKSCAN - a Pouch & Sachet Leak Tester Machine from Ireland-based Sepha Ltd. 3Prometheus Receives New York State Approval for PROMETHEUS(R) IBS Diagnostic, First Blood Test for Irritable Bowel Syndrome 2
...
Lyophilized. Purity: ≥90% by electrophoresis. Reconstitute in 0.3% NaCl. Prepared from serum that has been shown by certified tests to be negative for HBsAg and for HIV and HCV antibodies. ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
PP2B-Abeta (C-20)...
Biology Products: