Navigation Links
Genome study suggests new strategies for understanding and treating pulmonary fibrosis
Date:4/19/2013

A new genome-wide association study of more than 6,000 people has identified seven new genetic regions associated with pulmonary fibrosis. In findings published online in Nature Genetics on April 14, 2013, researchers at National Jewish Health, the University of Colorado and several other institutions found a number of genes associated with host defense, cell-cell adhesion and DNA repair, which provide clues to possible mechanisms underlying this currently untreatable disease.

"This research gives us several new targets for investigation of pulmonary fibrosis ," said David Schwartz, MD, senior author on the paper, Professor of Medicine at National Jewish Health and Chair of Medicine the University of Colorado School of Medicine. "We believe that there are several relatively common genetic risk factors, which combine with repeated lung injury to cause this devastating lung disease."

Pulmonary fibrosis is a potentially deadly scarring of lung tissue. Although there are a number of known contributors to its development, most cases have no known cause. Without an approved medical therapy, patients with the most common form, idiopathic pulmonary fibrosis, survive an average of only two to three years after diagnosis.

"Pulmonary fibrosis has resisted our attempts to find a clearly beneficial treatment," said co-author Kevin K. Brown, MD, Vice Chair of Medicine at National Jewish Health. "This study gives us new insights into how the disease develops. By better understanding this, we can better focus future therapies."

Researchers from more than 20 institutions, led by National Jewish Health and the University of Colorado, confirmed three previously reported genetic risk factors and identified seven new ones, which together account for about one-third of the disease risk.

The team's findings confirmed the risk associated with specific changes in MUC5B, a gene that produces a protein in mucus. Researchers believe
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coelacanth genome surfaces
2. Genome sequencing of the living coelacanth sheds light on the evolution of land vertebrate
3. Einstein joins the New York Genome Center as 12th institutional founding member
4. Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
5. Getting under the shell of the turtle genome
6. Peach genome offers insights into breeding strategies for biofuels crops
7. DOE Joint Genome Institute 8th Annual Meeting on March 26-28, 2013
8. ACMG releases report on incidental findings in clinical exome and genome sequencing
9. After the Genome tackles tough questions about medicine, miracles and morality
10. U of T scientists map genome that causes Dutch Elm Disease
11. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has ... Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of ... feature with the iPhone 5S. It is currently the ...
(Date:12/19/2014)...  23andMe, Inc., the leading personal genetics company, today announced the ... ancestry of individuals from across the United States ... four hundred years ago, the United States ... different continents. This study illuminates how American history and the ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally ... for the first time a fingerprint sensor in its ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... percent of the cells that shuttle sound to the brain are ... scientists know about how hearing works. Whether a rare, whisper-small second ... the brain and have a real role in processing sound has ... in the October 22 issue of Nature , a Johns ...
... Council,s Board on Life Sciences will hold a public ... discussions will explore the contributions the life sciences can ... the intersection of energy research and the life sciences, ... life sciences research can make to the food supply. ...
... have been discovered in the primate brain by a ... of physics at Penn State University and two neuroscientists ... the Massachusetts Institute of Technology (MIT). "This research ... been identified in recordings of neuron activity," Jin said. ...
Cached Biology News:Now hear this 2Time-keeping brain neurons discovered 2
(Date:1/22/2015)... RI (PRWEB) January 22, 2015 Protocol ... , The growing team of brand-neutral, independent consultants, Protocol ... Philip Rogers explained that over the years, his company ... , Moroso, Town of Plainfield, as well as others. ...
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... to Chief Financial Officer -, EXTON, Pa., ... today announced that it has appointed its new ... resources,clinical development and medical affairs. Charles Rowland has ... officer; Thomas Macnamara has,been promoted to the position ...
... Ltd, a cancer therapeutics,company, today announced the completion ... Bio*One Capital and new investor Aravis Venture.,Additional new ... by,Adamant Biomedical Investments AG and Zurcher Kantonalbank (ZKB). ... development efforts of its,two lead compounds, SB939, a ...
... via iMedica EHR provides patients with prescription ... DALLAS, Oct. 19 iMedica Corporation, a ... practices,announced today that it has partnered with ... ScriptGuide(R) to physician practices using,the iMedica Patient ...
Cached Biology Technology:ViroPharma Enhances Leadership to Support Global Growth and Expanding Business 2ViroPharma Enhances Leadership to Support Global Growth and Expanding Business 3ViroPharma Enhances Leadership to Support Global Growth and Expanding Business 4ViroPharma Enhances Leadership to Support Global Growth and Expanding Business 5S*BIO Completes US$26 Million Equity Financing 2S*BIO Completes US$26 Million Equity Financing 3S*BIO Completes US$26 Million Equity Financing 4iMedica Partners With LDM GROUP to Offer ScriptGuide to Physician Practice Customers 2iMedica Partners With LDM GROUP to Offer ScriptGuide to Physician Practice Customers 3
Request Info...
Recombinant Mouse sTNF RII/TNFRSF1B...
One-step, microplate or cuvet, colorimetric, linear detection range 0.2 mg/dL to 20 mg/dL. Procedure: 20 min....
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
Biology Products: