Navigation Links
Genome study shines light on genetic link to height
Date:9/2/2007

ying health condition. By defining the genes that normally affect stature, we might someday be able to better reassure parents that their childs height is within the range predicted by DNA, rather than a consequence of disease, said Hirschhorn.

Nearly 90% of the variation in height among most human populations can be attributed to DNA. The remainder is due to environmental and lifestyle factors, such as nutrition. Although a few genes have been uncovered through studies of rare, single-gene stature disorders, most do not seem to be associated with height in the general population. Recent advances, including the completion of the HapMap project and the availability of large-scale research tools, enabled the scientists to take a systematic approach to understand how common genetic differences can impact a persons height.

The results of the research team, which also includes co-senior authors Timothy Frayling of the Peninsula Medical School, Exeter and Mark McCarthy of the University of Oxford, spring from data made available in two recent genome-wide association studies of type 2 diabetes. The studies, one led by the Diabetes Genetics Initiative and the other by the Wellcome Trust Case Control Consortium, involved nearly 5,000 patients who generously volunteered DNA samples as well as pertinent clinical information, such as height and weight.

After scrutinizing the initial data, the scientists identified a single letter change known as a single nucleotide polymorphism or SNP in the HMGA2 gene as the most promising result. They collaborated with additional researchers to study this SNP through a second phase of analysis that encompassed nearly 30,000 individuals: adults and children from the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Exeter Family Study of Childhood Health (EFSOCH), European adults taking part in a study of type 2 diabetes risk (UKT2D GCC), Finnish individuals participating in the FINRISK1997 health s
'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
617-258-0952
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
3. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
4. Whole genome fine map of rice completed
5. Genome-wide mouse study yields link to human leukemia
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
10. Highly adaptable genome in gut bacterium key to intestinal health
11. Multiple Campylobacter Genomes Sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... PRINCETON, N.J. , Aug. 18, 2015 ... be a key contributor to the Submission ... hosted by IRISS, a non-profit forum. Dedicated to ... IRISS provides a neutral platform for industry, ... to share information and work towards a ...
(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions , ... entire spectrum of clinical research, is proud to announce ... company,s comprehensive SaaS-based eClinical technology platform, has led the ... first two quarters of 2015.   Q2 2015 and ... quarters measured by contract value sold in the company,s ...
(Date:8/12/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that four of its fingerprint ID products, ... been named FIDO Certified™ by the Fast IDentity ... Synaptics, Natural ID™ fingerprint solutions are fully compliant ... standard and are interoperable among other products and ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3MedNet Solutions Experiences Explosive Corporate Growth 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... food in northern Ghana difficult enough. It doesn,t help that ... to power tractors for planting crops or to power grain ... seeds from some native trees may be able to help. ... to create biodiesel from the seeds of trees that are ...
... the Exxon Valdez oil spill devastated a vast stretch of ... be unable to effectively manage a large oil spill, according ... 20th anniversary of the Exxon Valdez spill approaches on March ... offshore oil development in the Arctic until technologies improve to ...
... of Illinois plant geneticist Stephen Moose has developed a corn ... that would make good silage, Moose said, due to a ... make it a good energy crop. The gene known ... giving corn seedlings a waxy coating that acts like a ...
Cached Biology News:K-State researchers work with university in Ghana to create biofuels from native tree seeds 2Arctic governments and industry still unprepared for oil spills 20 years after Exxon Valdez 2Arctic governments and industry still unprepared for oil spills 20 years after Exxon Valdez 3Doubling a gene in corn results in giant biomass 2
(Date:9/2/2015)... NESS ZIONA, Israel , September ... BVXV, TASE: BVXV) today announced the intent of the National ... U.S. National Institutes of Health (NIH) within the Department of ... 2 trial to be held in the United ... examine the use of BiondVax,s universal flu vaccine candidate, Multimeric-001 ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... will improve efficiency of their entire waste to energy process and continue to ... Gets a Major Upgrade , Temarry’s Waste to Energy process has been operating ...
(Date:9/1/2015)... South Carolina (PRWEB) , ... September 02, 2015 , ... ... has released new features to its eCommerce site Spirax Sarco Anytime. This platform, ... , Why wait to place your next order? Log on to Spirax Sarco ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... the new ImageXpress® Micro Confocal High-Content Imaging System. This transformative system fits ... use 3D cellular models such as spheroids, tissues, and organisms. , ...
Breaking Biology Technology:BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2Spirax Sarco Announces New Features to Anytime Platform 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 3
... Plastics are everywhere in our modern world, largely due ... but lightweight and easily workable. One of their most ... than break when put under stress - is also ... "plastic flow", allows many plastics to change shape to ...
... U.S. Pharmacopeial (USP) Convention is pleased to announce that Matthew Heyman ... integration on December 1, 2008. , ... Rockville, Md. ... is pleased to announce that Matthew Heyman joined the organization ...
... new way of thinking in integrated imaging , ... the European Society of Nuclear Medicine meeting in October ... demand in a time when the current economical situation demands maximum ... reaches the United States as a pioneer, not only in hybrid ...
Cached Biology Technology:Fast molecular rearrangements hold key to plastic's toughness 2Fast molecular rearrangements hold key to plastic's toughness 3USP Names Matthew Heyman Vice President of External Affairs and Strategic Integration 2USP Names Matthew Heyman Vice President of External Affairs and Strategic Integration 3Imaging in Living Color with Siemens Molecular CT 2Imaging in Living Color with Siemens Molecular CT 3Imaging in Living Color with Siemens Molecular CT 4
... Immunogen: Partially purified ... MA1-710 detects vitamin D receptor (VDR) ... amphibian, and fish tissues. This ... or glucocorticoid receptors. MA1-710 detects ...
Unique enzyme blend containing Taq and Pwo DNA Polymerase and another thermostable enzyme. The Expand 20 kbPLUS PCR System also includes an optimized reaction buffer, MgCl2 solution, and a human cont...
... AccuPrime™ Pfx DNA Polymerase is ... fragments for downstream applications such as ... is provided by a proprietary enzyme ... Pyrococcus sp. with proofreading (3'Cut Site5' ...
... The EC105 power supply is a highly ... supply. A single adjustment knob and one hi-lo ... in 10 volt increments from 20 to 250 ... display from indicating output voltage to output current. ...
Biology Products: