Navigation Links
Genome study charts genetic landscape of lung cancer
Date:11/4/2007

the researchers uncovered a total of 57 genomic changes that occur frequently in lung cancer patients. Of these, only about 15 are linked to genes previously known to be involved in lung adenocarcinoma. The rest, though, remain to be discovered.

Strikingly, the most common abnormality identified in the Nature study involves a region on chromosome 14 that encompasses two known genes, neither of which had been previously associated with cancer. Through additional studies in cancer cells, co-first author Sue-Ann Woo and other researchers at Dana-Farber Cancer Institute revealed that one of the genes, NKX2.1, influences cancer cell growth. The NKX2.1 gene normally acts as a sort of master regulator controlling the activity of other key genes in a special group of cells lining the lungs tiny air sacs, called alveoli. This discovery, that a gene functioning in a select group of cells rather than all cells can promote cancer growth, may have broad implications for the design of novel, molecularly targeted cancer drugs.

The second phase of the TSP, now underway, will examine the same lung tumor samples analyzed in the first phase, but at an even greater level of genetic detail. Using high-throughput DNA sequencing methods, the scientists will characterize small changes in the genetic code of several hundred human genes, which are already implicated in other cancers or more generally in cell growth.


'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
3. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
4. Whole genome fine map of rice completed
5. Genome-wide mouse study yields link to human leukemia
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
10. Highly adaptable genome in gut bacterium key to intestinal health
11. Multiple Campylobacter Genomes Sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), ... crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz ... production capacity to meet customer demand. ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by ...
(Date:1/22/2015)... MADISON, Wis. , Jan. 15, 2015  BellBrook ... for drug discovery, announced the launch of a ... of the company,s Transcreener UDP Assay, a high ... enzymes. The new assay will allow for sensitive ...
(Date:1/22/2015)... OXFORD, Conn. , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: ... growing mobile commerce market, reports on the recent success of the Wocket™ ... Wocket smart wallet was named as one of the ... of the "5 Best Products Launched At CES So Far" by Newseveryday.com ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... in German . A joint ... Spain) and the Max Planck Institutes of Biochemistry ... and nanoscale resolved infrared mapping of strain fields ... near-field microscopy, opens new avenues for analyzing mechanical ...
... drought stress are the "dominant contributors" to a rapid increase ... during the past 50 years, a new report concludes, with ... The findings, to be published Friday in the journal ... mortality rate would ultimately cause a 50 percent reduction in ...
... 22, 2009 -- The Damon Runyon Cancer Research Foundation announced ... cancer have won the 2009 Damon Runyon-Rachleff Innovation Awards. ... year to three projects by early-career scientists that have the ... and treatment of cancer. The 2009 ...
Cached Biology News:Tension in the nanoworld 2Warmer climate causing huge increase in tree mortality across the West 2Warmer climate causing huge increase in tree mortality across the West 32009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research 22009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research 32009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research 4
(Date:1/22/2015)... January 22, 2015 Crystal Diagnostics (CDx) Xpress ... it has received AOAC-PTM Certifications for the six non-O157 Shiga ... O145; collectively referred to as STEC or the “Big-6”) as ... forming unit (cfu) per 325 g of raw ground beef ...
(Date:1/22/2015)... zFlo Motion , a US leader in biomechanics software ... a new partner. STT-Systems has developed an impressive ... with offerings in the optical-motion capture, 3D scanning, and industrial ... unit), iSen, is opening eyes around the world. With no ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project managed ... legal requirements around using controlled substances in pharmaceutical research, ... their international operations expand and become increasingly complex, large ... a result of the first phase of the CSCS ...
(Date:1/22/2015)... Denville, NJ (PRWEB) January 22, 2015 ... shearing technologies such as the Bioruptor® and complete ... semi-automation system for chromatin immunoprecipitation, alleviating the need ... reagents and controls needed for ChIP of histones ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... Starting Wednesday, Starbucks customers in Wisconsin can ... than 3,100 company-owned Starbucks stores nationwide and now ... HotSpot service for patrons with Wi-Fi-enabled notebook computers. ... activating a T-Mobile HotSpot account. Various pricing plans are ...
... if done extremely well, is a powerful key to ... if done poorly, is an enormous marketing obstacle? The ... a direct impact on how effectively you are able ... share some delegation tips on how to maximize your ...
... WATERLOO, Wis. - Coming out of the Tour de France ... are once again in the lead. That must make the designers ... team is riding. , ,Founded in 1976 in Waterloo, Wisconsin, the ... and it is now hoping its latest designs will help lead ...
Cached Biology Technology:Fire up your marketing by delegating 2Armstrongs new Trek modeled on AMD 64-bit processors 2
... new HydroFlex platform provides excellent performance, ... of 96-well format applications, including washing ... arrays, and vacuum filtration-to-waste, such as ... on-line control features set new standards ...
... Obtain Clean and Accurate Results Laser ... increase the sensitivity and accuracy of molecular ... cell types and multi-cellular structures isolated from ... approach to microdissection-developed in 1996 at the ...
... raised against a partial recombinant ... ZFHX4 (NP_078997, 2 a.a. ... protein with GST tag. ... NM_024721 Protein ...
... binding specificity and signaling of the members ... be modified by alternative splicing--which has important ... you can perform a classical expression profiling ... different alternatively spliced forms of the gene ...
Biology Products: