Navigation Links
Genome study charts genetic landscape of lung cancer
Date:11/4/2007

the researchers uncovered a total of 57 genomic changes that occur frequently in lung cancer patients. Of these, only about 15 are linked to genes previously known to be involved in lung adenocarcinoma. The rest, though, remain to be discovered.

Strikingly, the most common abnormality identified in the Nature study involves a region on chromosome 14 that encompasses two known genes, neither of which had been previously associated with cancer. Through additional studies in cancer cells, co-first author Sue-Ann Woo and other researchers at Dana-Farber Cancer Institute revealed that one of the genes, NKX2.1, influences cancer cell growth. The NKX2.1 gene normally acts as a sort of master regulator controlling the activity of other key genes in a special group of cells lining the lungs tiny air sacs, called alveoli. This discovery, that a gene functioning in a select group of cells rather than all cells can promote cancer growth, may have broad implications for the design of novel, molecularly targeted cancer drugs.

The second phase of the TSP, now underway, will examine the same lung tumor samples analyzed in the first phase, but at an even greater level of genetic detail. Using high-throughput DNA sequencing methods, the scientists will characterize small changes in the genetic code of several hundred human genes, which are already implicated in other cancers or more generally in cell growth.


'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
3. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
4. Whole genome fine map of rice completed
5. Genome-wide mouse study yields link to human leukemia
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
10. Highly adaptable genome in gut bacterium key to intestinal health
11. Multiple Campylobacter Genomes Sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... have hit on a novel method to help ... and most effective treatment possible., Kidney stones represent ... developing world. If left untreated, apart from being ... and other complications. In many patients treated successfully, ... more effective pathological approach to diagnosis and treatment ...
(Date:4/17/2014)... meeting painted a stark warning on the possible effects ... greenhouse effect 32 times that of carbon dioxide. Now ... substances act as fully regenerable electron acceptors which helps ... wetlands instead of being released to the atmosphere. However, ... it may enter into a vicious cycle to release ...
(Date:4/17/2014)... University researchers have detected new early-warning signs of the ... could have far-reaching implications for the diagnosis and treatment ... 25 million Americans. , "We had not expected to ... early stages," said Ann Elsner, professor and associate dean ... of the study. "We set out to study the ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... Gary Hoyle, PhD, professor, University of Louisville School of ... research to develop an effective medical treatment to counteract ... of terrorism. The National Institute of Environmental Health Sciences ... have awarded Hoyle $2.6 million over five-years to further ...
... in the southeastern United States, and for scientists trying to ... ) is not cooperating. So far botanists have ... plant to boiling water, dry heat up to 284 degrees ... coax them into germination. Nothing has worked. "Complete ...
... and conservation successes in the face of rapid environmental ... plants adapt to local climate. To improve scientists, ... 7, 2011 issue of Science helps define ... The National Science Foundation partly funded the study, ...
Cached Biology News:UofL researcher awarded $2.6 million NIH grant renewal 2Super-tough seed coat keeps Michaux's sumac on critically endangered list 2
(Date:1/15/2014)... January 15, 2014 Freeslate, Inc ... today announced that Lupin Limited, one of India’s top ... CM Protégé PharmD System for high throughput solid ... is focused on a wide range of quality, affordable ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... on the products of cells grown under simulated embryonic ... international license agreement with Suneva Medical, Inc. for physician-dispensed ... (CCM). , This agreement is an amendment ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. ... together with two institutes from the National Institutes of ... for bringing safer, more effective treatments to patients on ... Center for Advancing Translational Sciences (NCATS) and the National ...
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, provider of ... and sales and operations planning ( S&OP ) service, is ... Summit , which will be held at the Hilton San ... join Kinaxis customer Elisabeth Kaszas , Director of Supply ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... April 12, 2011 Drs. Rodney Landreneau and ... non small cell lung cancer study at the 2011 Society ... Landreneau is Director of the Lung Center at UPMC Shady ... at UPMC Passavant Medical Center and Director of the Division ...
... 12, 2011 Biotech Medical, Inc. is set to ... SpectraSan™ "Hungry Enzymes". The products will be available for ... a Pet Stain & Odor Eraser, Spa & Whirlpool ... All-Purpose Cleaner & Degreaser, Glass & Stainless Steel Cleaner ...
... Dr. Fresh®, Inc., maker of the popular FireFly® children,s ... to raise awareness and funds for Smile Train, the ... company will donate $1 for every new "Like" on ... Smile Train.  The organization provides life-changing surgery for poor ...
Cached Biology Technology:Precision Therapeutics' ChemoFx® Demonstrates Significant Role in Selection of Chemotherapy Doublets in Non Small Cell Lung Cancer 2Biotech Medical, Inc. Introduces a Full Line of Enzyme Cleaners 2FireFly® Toothbrush Facebook Campaign Raises Funds for Smile Train 2