Navigation Links
Genome study charts genetic landscape of lung cancer
Date:11/4/2007

cer is the leading cause of cancer deaths worldwide each year more than 1 million people die of the disease, including more than 150,000 in the United States. New approaches to treatment rely on a deeper understanding of what goes wrong in cells to spur cancer growth. Through decades of research, it has become clear that lung cancer like most human cancers stems mainly from DNA changes that accrue in cells throughout a persons life. But the nature of these changes and their biological consequences remain largely unknown.

To assemble a genome-wide catalog of genetic differences in lung cancer cells, a large-scale project was recently launched in lung adenocarcinoma. The effort, known as the Tumor Sequencing Project (TSP), unites scientists and clinicians throughout the cancer research community.

The TSP researchers studied more than 500 tumor specimens from lung cancer patients. Access to this large collection of high-quality samples made it possible to determine the genetic changes shared among different patients such recurring changes can highlight important genes involved in cancer growth. This project was made possible through the foresight of a dedicated group of oncologists, pathologists, and surgeons, who carefully and diligently preserved tissues from lung cancer patients over many years, said Meyerson.

To analyze DNA from each lung tumor, the scientists relied on recent genomic technologies to scan the human genome for hundreds of thousands of genetic markers, called single nucleotide polymorphisms or SNPs. This high-resolution view helped pinpoint which parts of the tumor genome were present in excess copies or missing altogether. The regions of genomic aberration were then identified with new analytical tools, including a computational method called GISTIC and methods for visualizing SNP data developed by co-first authors Gaddy Getz and Barbara Weir and co-authors Rameen Beroukhim and Jim Robinson.

From this work,
'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
3. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
4. Whole genome fine map of rice completed
5. Genome-wide mouse study yields link to human leukemia
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
10. Highly adaptable genome in gut bacterium key to intestinal health
11. Multiple Campylobacter Genomes Sequenced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... , March 31, 2015  Elephant Talk Communications ... a global provider of Software Defined Network Architecture (ET ... announced total revenue of approximately $20.4 million for the ... restated $19.5 million for the year ended December 31, ... 2014, the Company had completed its multi-year transition away ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... with critical security-authentication needs, today announced the beginning of ... (FFD) solution. The company, based in ... at the three-day Connect:ID Expo, which began here today ... NexID said version 2.0 of its SDK boosts the ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... An international consortium of scientists, including Universitat Autnoma ... genome of three species of parasitoid wasps of the ... information on the genetic mechanisms of evolution. It is ... pests and of insect-borne diseases, since parasitoid wasps bite ...
... American Recovery and Reinvestment Act (ARRA) the economic ... 100 examples of how a relatively small element of ... for the nation. Of the $787 billion contained ... and science infrastructure. ScienceWorksForUS, a coalition of three ...
... , PISCATAWAY, N.J. , Feb. 17 ... launch of a substantial upgrade to the IEEE Xplore ... interface and customizable search tools make exploring IEEE,s more than ... productive. Users can now spend less time researching and more ...
Cached Biology News:Genome sequencing of 3 parasitoid wasp species 2Universities highlight benefits of stimulus research funding 2Universities highlight benefits of stimulus research funding 3IEEE Launches Major Upgrade of IEEE Xplore(R) Digital Library 2IEEE Launches Major Upgrade of IEEE Xplore(R) Digital Library 3IEEE Launches Major Upgrade of IEEE Xplore(R) Digital Library 4
(Date:4/17/2015)... 17, 2015 Reed Technology and ... regulatory data management, preparation, and submission to the U.S. ... of a new Lot Distribution Report (LDR) service for ... remain compliant with the FDA’s new rule on electronic ... to monitor the volume and timing of particular biologics ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Global ... the GTCbio Stem Cell Summit 2015 April 27 - ... the latest developments in all areas of stem cell ... of stem cells and regenerative medicine. , The ... trials, as well as translational research in stem cell ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
(Date:4/16/2015)... April 16, 2015 Regis Technologies looks ... Association for Cancer Research (AACR) annual meeting. Regis will ... Center, starting Saturday, April 18, in Philadelphia and running ... to title of the oldest and largest organization focused ... and grants, and partners with survivors to promote awareness ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
... of Pittsburgh School of Dental Medicine are piecing together ... to novel nanoscale approaches to developing biomaterials. The findings ... of the National Academy of Sciences . Dental ... and combines high hardness with resilience, said Elia Beniash, ...
... NeoStem, Inc. (NYSE Amex: NBS ) ("NeoStem" ... focus on cell based therapeutics development, today announced that ... Program (PRMRP) of the Office of the Congressionally Directed ... be applied towards funding the Company,s VSEL™ Technology. This ...
... testing within the pharmaceutical and cosmetic industries and companies ... their products are safe to use. Research published in ... demonstrates that the response of laboratory grown human cells ... or non-sensitizing, and can even predict the strength of ...
Cached Biology Technology:NeoStem Announces the Receipt of Over $1,700,000 in DOD Funding for its VSEL™ Technology Being Developed to Treat Osteoporosis 2NeoStem Announces the Receipt of Over $1,700,000 in DOD Funding for its VSEL™ Technology Being Developed to Treat Osteoporosis 3NeoStem Announces the Receipt of Over $1,700,000 in DOD Funding for its VSEL™ Technology Being Developed to Treat Osteoporosis 4Cell-based alternative to animal testing 2
The Light Diagnostics Calicivirus Genotype 1&2 Typing OligoDetect assay is applicable for the qualitative detection of calicivirus RNA generated by an in-house validated in vitro nucleic acid amplifi...
Recombinant Rat CINC-2 alpha, CF...
sodium channel, nonvoltage-gated 1 alpha,...
MOUSE ANTI HUMAN B-CELLS (FMC7):FITC Immunogen: HRIK cells - Human B-Lymphoblastoid line...
Biology Products: