Navigation Links
Genome-scale network of rice genes to speed the development of biofuel crops

The first genome-scale model for predicting the functions of genes and gene networks in a grass species has been developed by an international team of researches that includes scientists with the U.S. Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI), a multi-institutional partnership led by Lawrence Berkeley National Laboratory (Berkeley Lab). Called RiceNet, this systems-level model of rice gene interactions should help speed the development of new crops for the production of advanced biofuels, as well as help boost the production and improve the quality of one of the world's most important food staples.

"With RiceNet, instead of working on one gene at a time based on data from a single experimental set, we can predict the function of entire networks of genes, as well as entire genetic pathways that regulate a particular biological process," says Pamela Ronald, a plant geneticist who holds joint appointments with JBEI, where she directs the grass genetics program, and with the University of California (UC) Davis, where she is a professor in the Department of Plant Pathology and at The Genome Center. "RiceNet represents a systems biology approach that draws from diverse and large datasets for rice and other organisms."

Rice is staple food for half the world's population and a model for monocotyledonous species one of the two major groups of flowering plants. Rice is especially useful as a model for the perennial grasses, such as Miscanthus and switchgrass, that have emerged as prime feedstock candidates for the production of clean, green and renewable cellulosic biofuels.

Given the worldwide importance of rice, a network modeling platform that can predict the function of rice genes has been sorely needed. However, until now the high number of rice genes in excess of 41,000 compared to about 27,000 for Arabidopsis, a model for the other major group of flowering plants along with several other important factors, has proven to be too great a challenge.

Ronald is the corresponding author of a paper in the Proceedings of the National Academy of Sciences (PNAS) that describes how JBEI researchers, working with researchers at the University of Texas in Austin, and Yonsei University in Seoul, Korea, overcame the challenge and developed a network that encompasses nearly half of all rice genes. The paper is titled "Genetic dissection of the biotic stress response using a genome-scale gene network for rice."

"RiceNet builds upon 24 publicly available data sets from five species as well as an earlier mid-sized network of 100 rice stress response proteins that my group constructed through protein interaction mapping," Ronald says. "We have conducted experiments that validated RiceNet's predictive power for genes involved in the rice innate immune response."

Ronald and her team also showed that RiceNet can accurately predict gene functions in another important monocotyledonous crop species, maize.

A RiceNet Website is now available that allows researchers from all over the world to use it. At JBEI, RiceNet will be used to identify genes that have not previously been known to be involved in cell wall synthesis and modification. JBEI researchers are looking for ways to increase the accessibility of fermentable sugars in the cell walls of feedstock plants.

"The ability to identify key genes that control simple or complex traits in rice has important biological, agricultural, and economic consequences," Ronald says. "RiceNet offers an attractive and potentially rapid route for focusing crop engineering efforts on the small sets of genes that are deemed most likely to affect the traits of interest."


Contact: Lynn Yarris
DOE/Lawrence Berkeley National Laboratory

Related biology news :

1. Vast hidden network regulates gene expression in cancer
2. Over the hump: Ecologists use power of network science to challenge long-held theory
3. University of Tennessee chosen to join national network to study climate change
4. Watching viruses friend a network
5. Disordered networks synchronise faster than small world networks
6. Wireless network in hospital monitors vital signs
7. NSF awards construction funding to National Ecological Observatory Network
8. 1st large-scale map of a plants protein network addresses evolution, disease process
9. Caltech researchers create the first artificial neural network out of DNA
10. Notre Dame research reveals brain network connections
11. Data revealing migrations of larval reef fish vital for designing networks of marine protected areas
Post Your Comments:
Related Image:
Genome-scale network of rice genes to speed the development of biofuel crops
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced expansion of its TDDI ... touch controller and display driver integration (TDDI) ... smartphones. These new TDDI products add to the ... resolution), TD4302 (WQHD resolution), and TD4322 (FHD resolution) ...
(Date:11/10/2015)... 2015  In this report, the biomarkers ... product, type, application, disease indication, and geography. ... are consumables, services, software. The type segments ... efficacy biomarkers, and validation biomarkers. The applications ... development, drug discovery and development, personalized medicine, ...
(Date:11/2/2015)... MENLO PARK, Calif. , Nov. 2, 2015 /PRNewswire/ ... to $9 million to provide preclinical development services to ... Under the contract, SRI will provide scientific expertise, modern ... a wide variety of preclinical pharmacology and toxicology studies ... --> --> The PREVENT Cancer Drug ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 Studies reveal the differences ... and pave the way for more effective treatment for one ...   --> --> ... problems in cats, yet relatively little was understood about the ... have been conducted by researchers from the WALTHAM Centre for ...
(Date:11/25/2015)... DIEGO , Nov. 25, 2015  Neurocrine Biosciences, ... Kevin Gorman , President and CEO of Neurocrine Biosciences, ... Healthcare Conference in New York . ... to visit the website approximately 5 minutes prior to ... A replay of the presentation will be available on ...
(Date:11/25/2015)... IN (PRWEB) , ... November 25, 2015 , ... ... (AMA) and the Organization of Black Aerospace Professionals (OPBAP) has been formalized with ... and other AMA team leaders met with OPBAP leaders Capt. Karl Minter and ...
(Date:11/25/2015)... 2015 The Global Genomics ... professional and in-depth study on the current state ... ) , The report ... definitions, classifications, applications and industry chain structure. The ... markets including development trends, competitive landscape analysis, and ...
Breaking Biology Technology: