Navigation Links
Genome 10K Project announces first 101 species for genome sequencing
Date:11/30/2010

SANTA CRUZ, CA--The Genome 10K Community of Scientists and BGI (formerly the Beijing Genomics Institute) of Shenzhen, China, have announced a plan to sequence the genomes of 101 vertebrate species within the next two years, the first of an eventual 10,000 species to be sequenced by the Genome 10K Project.

The Genome 10K Project (G10K) is an international effort to gather specimens of thousands of animals from zoos, museums, and university collections throughout the world, and then sequence the genome of each species to reveal its complete genetic heritage. The project aims to assemble a genomic zoo--a collection of DNA sequences for 10,000 vertebrate species (approximately one for every vertebrate genus) by 2015.

Genome 10K cofounder David Haussler, a professor of biomolecular engineering in the Baskin School of Engineering at UC Santa Cruz, said the first 101 species to be sequenced were selected from the Genome 10K database, which catalogs specimens suitable for sequencing from more than 16,000 vertebrate species, both living and recently extinct. (A list of the selected species is available for download.)

"These genomes will provide a new and exciting window into vertebrate biology," Haussler said. "The experiments of evolution represented in them carry critical information about how animals are built and how they function at the molecular level."

The planned sequencing will take place within the next 24 months at the BGI facilities in China. BGI has recently amassed the largest number of advanced DNA sequencing machines under one roof of any institute in the world and is committed to large-scale application of genome sequencing in science and medicine.

"With this joint pledge to accomplish whole-genome sequence assembly and annotation of 101 new vertebrate species--the first 1 percent of the Genome 10K target--we move much closer to providing students of biology the unabridged DNA code book for the wonder of living vertebrate forms," said project cofounder Stephen J. O'Brien, chief of the Laboratory of Genomic Diversity at the National Cancer Institute.

The sequencing project builds on a BGI project launched in January 2010, called the 1,000 Plant and Animal Reference Genome Project. According to BGI executive director Jun Wang, their project harnesses the leading sequencing platform, advanced technologies, and powerful bioinformatics analytical capability.

"The collaboration with G10K will not only significantly facilitate the progression of BGI's genomics research, but also benefit the development of global genomics researches and their relevant industrial application," Wang said.

The 101 vertebrate species chosen for this phase of the project were selected by a consortium of BGI scientists, their collaborators, sponsors, and the chairs of the Genome 10K taxonomy groups for mammals, birds, amphibians, reptiles, and fish. The species were chosen to capture phylogenetic diversity across the vertebrate radiations while avoiding overlap with public-sponsored whole-genome sequencing projects. Other considerations included the biological features that make a species interesting to humankind, the science community around each species, and the availability of vouchered specimens.

According to Genome 10K cofounder Oliver Ryder, director of genetics at the San Diego Zoo Institute for Conservation Research, the collection and banking of samples in international centers, such as San Diego's Frozen Zoo, sets the stage for rapid progress toward the sequencing goals in collaboration with major sequencing centers, such as BGI. "The data produced provide a major contribution to understanding aspects of the biology of many endangered species, thereby assisting in conservation efforts on their behalf," Ryder said.

In addition to the 101 species chosen for G10K, there are 120 vertebrate species already being sequenced in public-sector genome projects (download list here). The completion of 221 whole-genome sequences within a few years is a first step toward the G10K goal of obtaining high-quality whole-genome sequences, assembled and annotated, for 10,000 vertebrate species. To meet the quality goals of the G10K project, every species must have a reference genome sequence with chromosome-scale contiguity suitable for display on a genome browser and accurate enough for genome-based research.

Selection of future species for sequencing in the Genome 10K project will involve open-science-based input and collaboration, Haussler said. Haussler's team at UCSC's Center for Biomolecular Science and Engineering maintains the Genome 10K database and the UCSC Genome Browser.

The Genome 10K Project will hold a workshop in Santa Cruz, California, from March 14 to 18, 2011. This workshop will accomplish two goals: First, it will continue the mission to gather biological specimens of vertebrate species and describe them thoroughly on a public database. Second, it will gather genome assembly experts to develop a robust solution to the challenge of creating useful assembly with short reads and combined-scaffold assembly approaches.


'/>"/>

Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz
Source:Eurekalert

Related biology news :

1. MU plant genome research receives $3 million boost from National Science Foundation
2. ASPB members lead new plant genome research program awards
3. Is the shape of a genome as important as its content?
4. NSF awards new projects for plant genome research
5. NSF awards $3.75 million grant to New York Plant Genome Consortium for the creation of BigPlant v1.0
6. NIH-funded scientists sequence genomes of lyme disease bacteria
7. Singapore scientists first to perform genome-wide study of human stem cells
8. UBC gains $5.4 million for microbiome research from CIHR, Genome BC
9. UF to help sequence genome of flowering plants ancient living relative
10. Genome inversion gives plant a new lifestyle
11. Genomic haircut makes worlds tiniest genome even smaller: UBC research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: