Navigation Links
Geniposide protects hippocampal neurons via the non-classical estrogen signaling pathway
Date:5/7/2014

Amyloid-β (Aβ) plaques and neurofibrillary tangles are the main pathological hallmarks of Alzheimer's disease, as well as the loss of neurons and synapses. recent reports have shown that estrogen exerts neuroprotective effects. However, large clinical trials in postmenopausal women indicated adverse side-effects of estrogens, such as increased incidence of breast cancer and metrocarcinoma, thereby preventing clinical use of estrogen. Tongluojiunao (TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. Prof. Qian Hua and team from Beijing University of Chinese Medicine in China pointed out that primary cultured hippocampal neurons treated with Aβ1-β significantly increased the release of lactate dehydrogenase, which was markedly reduced by TLJN, specifically by the component geniposide, but not ginsenoside Rg1. They also found that the estrogen receptor inhibitor did not block TLJN- or geniposide-mediated decrease of lactate dehydrogenase under Aβ1-β-exposed conditions. However, the non-classical estrogen pathway inhibitor blocked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. Therefore, these results, published in the Neural Regeneration Research (Vol. 9, No. 5, 2014), suggest that the non-classical estrogen pathway (i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, specifically its component, geniposide, against Aβ1-β-mediated cell death in primary cultured hippocampal neurons.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. It slices, it dices, and it protects the body from harm (Science)
2. New molecule protects brain from detrimental effects linked to diabetes and high blood sugar
3. Researchers identify innate channel that protects against pain
4. Cancer drug protects against diabetes
5. Slippery bark protects trees from pine beetle attack, according to CU-Boulder study
6. Regular exercise in middle age protects against muscle weakness later in life
7. Education protects women from the obesity associated with urban living
8. Doubling the daily allowance of protein intake with diet and exercise protects muscle loss
9. HB-EGF protects intestines from a variety of injuries, pair of studies suggests
10. Neuroblastoma: Autophagy protects from chemotherapy
11. Parkinsons disease: Parkin protects from neuronal cell death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Geniposide protects hippocampal neurons via the non-classical estrogen signaling pathway
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... The first ... took 20 years until the first data on cross-contamination of human cell lines with ... been an increasing issue in cell culture labs and is associated with dramatic consequences ...
(Date:6/20/2017)... ... 20, 2017 , ... HorizonScan is providing food and ingredient ... likely threat to their products at the annual IFT conference in Las Vegas, ... expo attracts over 20,000 attendees representing food science professionals from over 90 countries ...
(Date:6/19/2017)... ... June 19, 2017 , ... ... activities supporting EDETEK’s products including training, implementation, support, and client process and SOP ... role. He has previously held leadership roles for service providers and top-tier pharmaceuticals, ...
(Date:6/16/2017)... ... June 16, 2017 , ... Cambridge ... announced that its Anzo Smart Data Lake® (Anzo SDL) solution was named ... the 2017 Software & Information Industry Association (SIIA) CODiE Awards. , Finalists ...
Breaking Biology Technology: