Navigation Links
Genetics underlie formation of body's back-up bypass vessels

CHAPEL HILL Researchers at the University of North Carolina at Chapel Hill School of Medicine have uncovered the genetic architecture controlling the growth of the collateral circulation the "back-up" blood vessels that can provide oxygen to starved tissues in the event of a heart attack or stroke.

The new knowledge could help inform the current development of what are called collaterogenic therapies drugs or procedures that can cause new collaterals to form and enlarge before or after a person suffers tissue damage from a blocked artery in the heart, brain, or peripheral tissues.

"This has really been the holy grail in our field, how to get new collaterals to form in a tissue with few in the first place" said senior study author James E. Faber, PhD, professor of cell and molecular physiology at UNC. "Our thesis has been that if we can figure out how these endogenous bypasses are formed in the first place in healthy tissues, what mechanisms and genetic pathways drive this, and collaterals abundance varies so widely in healthy individuals, then we may have our answer."

The results of the research, published in the August 20, 2010, issue of the journal Circulation Research, is the first to pinpoint a portion of the genome associated with variation in the density and diameter of collateral vessels.

"This may well be the seminal paper in one of the most important mysteries in vascular biology: the mechanisms controlling collateral formation in the arterial tree," wrote Stephen Schwartz, a professor of physiology at the University of Washington, in a review of the study for Faculty 1000.

The UNC research, conducted in animal models, combined classical genetic mouse crosses with a new genomic technology called association mapping to identify the section of DNA involved, starting with the whole genome, narrowing it down to several hundreds of genes and finally landing on nine candidates on mouse chromosome 7.

The researchers are now looking at these genes to see if any one of them is responsible for variation in collateral formation. Faber says they also cannot discount the possibility that it is not genes that are the deciding factor, but rather regulatory DNA or RNA elements that also reside in that same section of the genome. Either way, Faber hopes they can discover a sequence that could one day be used to predict who is most likely to develop a severe heart attack, stroke, or peripheral limb disease so those individuals can either modify their lifestyle or receive collaterogenic drugs to acquire new and potentially life-saving collateral vessels.


Contact: Les Lang
University of North Carolina School of Medicine

Related biology news :

1. Economic status, genetics together influence psychopathic traits
2. Study finds diet and alcohol alter epigenetics of breast cancer
3. HPC for phylogenetics tutorial aims to reduce analysis time
4. Genetics in bloom
5. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
6. Genetics Society of America to host Model Organisms to Human Biology Meeting, June 12-15, 2010
7. Genetics Society of America announces award recipients at 51st Annual Drosophila Conference
8. National Academy of Sciences recognizes Southampton genetics scientist
9. Ayman El-Hattab, MD is awarded the 2010 Genzyme/ACMG Foundation Genetics Fellowship
10. Leader in genetics, Dr. David L. Rimoin, receives ACMG Foundation Lifetime Achievement Award
11. Dian Donnai receives lifetime award in genetics from March of Dimes
Post Your Comments:
Related Image:
Genetics underlie formation of body's back-up bypass vessels
(Date:10/9/2015)... ) ... "Samsung Galaxy S6 Fingerprint Sensor - Reverse ... --> ) has announced ... S6 Fingerprint Sensor - Reverse Costing Analysis" ... Research and Markets ( ) ...
(Date:10/8/2015)... 8, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... smart wallet announces that revenues for the three ... compared with $113,00 for the three months ended ... ended September 30, 2015 were approximately $520,000. ...
(Date:10/6/2015)... CITY , Oct. 6, 2015 Track ... announced today that it has signed a contract with ... services across the full range of sentences under the ... President of the Americas. "This contract with the Virginia ... of the US and advances our position as a ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... ... October 13, 2015 , ... Clinovo recently appointed Jeff Parr and Ed Donaldson ... clinical data solutions business. , Jeff Parr has spent the past decade providing quality ... Dennison, Thermo Fisher, and Ab Sciex to name a few. He is based ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... educational opportunities for school age children in the areas of Science, Technology, Engineering ... sectors of the national economy, and the program aims to increase the number ...
(Date:10/12/2015)... ... October 12, 2015 , ... Spirax Sarco, the leader in products and services ... 600 compact clean steam generator . This unit is a skid mounted system ... HTM2010, and EN285 standards. The CMS-C 600 generator can produce up to a ...
(Date:10/12/2015)... , Oct. 12, 2015  Rebiotix Inc. today ... has designated its lead Microbiota Restoration Therapy (MRT) ... of recurrent Clostridium difficile (C diff) ... that causes 29,000 deaths in the U.S. annually. ... company that was founded to revolutionize the treatment ...
Breaking Biology Technology: