Navigation Links
Genetics underlie formation of body's back-up bypass vessels
Date:8/19/2010

CHAPEL HILL Researchers at the University of North Carolina at Chapel Hill School of Medicine have uncovered the genetic architecture controlling the growth of the collateral circulation the "back-up" blood vessels that can provide oxygen to starved tissues in the event of a heart attack or stroke.

The new knowledge could help inform the current development of what are called collaterogenic therapies drugs or procedures that can cause new collaterals to form and enlarge before or after a person suffers tissue damage from a blocked artery in the heart, brain, or peripheral tissues.

"This has really been the holy grail in our field, how to get new collaterals to form in a tissue with few in the first place" said senior study author James E. Faber, PhD, professor of cell and molecular physiology at UNC. "Our thesis has been that if we can figure out how these endogenous bypasses are formed in the first place in healthy tissues, what mechanisms and genetic pathways drive this, and collaterals abundance varies so widely in healthy individuals, then we may have our answer."

The results of the research, published in the August 20, 2010, issue of the journal Circulation Research, is the first to pinpoint a portion of the genome associated with variation in the density and diameter of collateral vessels.

"This may well be the seminal paper in one of the most important mysteries in vascular biology: the mechanisms controlling collateral formation in the arterial tree," wrote Stephen Schwartz, a professor of physiology at the University of Washington, in a review of the study for Faculty 1000.

The UNC research, conducted in animal models, combined classical genetic mouse crosses with a new genomic technology called association mapping to identify the section of DNA involved, starting with the whole genome, narrowing it down to several hundreds of genes and finally landing on nine candidates on mouse chromosome 7.'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Economic status, genetics together influence psychopathic traits
2. Study finds diet and alcohol alter epigenetics of breast cancer
3. HPC for phylogenetics tutorial aims to reduce analysis time
4. Genetics in bloom
5. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
6. Genetics Society of America to host Model Organisms to Human Biology Meeting, June 12-15, 2010
7. Genetics Society of America announces award recipients at 51st Annual Drosophila Conference
8. National Academy of Sciences recognizes Southampton genetics scientist
9. Ayman El-Hattab, MD is awarded the 2010 Genzyme/ACMG Foundation Genetics Fellowship
10. Leader in genetics, Dr. David L. Rimoin, receives ACMG Foundation Lifetime Achievement Award
11. Dian Donnai receives lifetime award in genetics from March of Dimes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics underlie formation of body's back-up bypass vessels
(Date:7/11/2014)... from Ume University, Sweden, have explored two different ... reaction sequence leading to the formation of oxygen ... published in the scientific journal Nature Communications ... present day synthetic catalysts for water oxidation, which ... for the direct storage of solar energy in ...
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/10/2014)... In Santa Fe, Albuquerque, and other major cities in ... watered with treated municipal wastewater rather than precious potable ... more than 40% of all golf courses receive treated ... courses. , Additionally, golf courses and homeowners alike ... nutrient in fertilizer is nitrate. A New Mexico State ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... normal immune cells to become specialized tumor fighters, demonstrating for ... the body and shrink large tumors in humans. , ... the experimental treatment saw their tumors shrink and were declared ... after the therapy began, Steven A. Rosenberg of the National ...
... bacterial perpetrator of the often severe disease caused ... keep looking: Scientists at the National Institute of ... National Institutes of Health, have exonerated a toxin ... Panton-Valentine leukocidin (PVL) is one of many toxins ...
... dot on his computer screen. The dot ?which represents ... into a mass with finger-like projections that looks like ... biology envisions a future when computer simulations like this ... and formulate individualized treatment plans. For the last two ...
Cached Biology News:Science researchers genetically transform immune cells into tumor fighters 2Science researchers genetically transform immune cells into tumor fighters 3MRSA toxin acquitted: Study clears suspected key to severe bacterial illness 2MRSA toxin acquitted: Study clears suspected key to severe bacterial illness 3Math model predicts cancer behavior 2Math model predicts cancer behavior 3Math model predicts cancer behavior 4
(Date:7/10/2014)... Capital, a firm specializing in acquiring and managing food ... the Slim-Fast brand from Unilever. Unilever will retain a ... were not disclosed. Slim-Fast is a branded ... shakes, powders, bars and snacks to retail customers throughout ... United Kingdom and Ireland.  The ...
(Date:7/10/2014)... in the fight against terrorism with the creation of ... with the use of light and special glass fibres. ... B: Chemical , the researchers describe a novel optical ... low as 6.3 ppm (parts per million). It requires ... "Traditionally explosives detection has involved looking for metals that ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:1/15/2014)... approach akin to assembling a club sandwich at ... (NIST) researchers have succeeded in crafting a uniform, ... of foam commonly used in upholstered furniture and ... nanotube-coated polyurethane foam was reduced 35 percent compared ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... April 15 Hovione is pleased to announce,that ... that it intends,to use Hovione,s TwinCaps(R) dry powder ... an inhaled long-acting neuraminidase inhibitor active,against the influenza ... III clinical trials in Japan and other Asian ...
... MADISON, N.J., April 15 Quest Diagnostics,Incorporated (NYSE: ... resolution of the,previously disclosed federal government investigation related ... kit manufacturing subsidiary closed,voluntarily in 2006. Quest Diagnostics ... 2004. , Quest Diagnostics ...
... Development for Neurological ConditionsBROOMFIELD, Colo., April 15 ... in central nervous system (CNS) diseases, announced today ... development company. The new company will focus ... molecule drugs for acute and chronic neurological conditions ...
Cached Biology Technology:Hovione's TwinCaps(R) Inhaler in Phase III Clinical Trials for Influenza 2Hovione's TwinCaps(R) Inhaler in Phase III Clinical Trials for Influenza 3Quest Diagnostics Finalizes Previously Announced Settlement With Government Related to Test Kit Subsidiary Closed in 2006 2Accera, Inc. Launches Neuera Pharmaceuticals, Inc. 2Accera, Inc. Launches Neuera Pharmaceuticals, Inc. 3
lid holder -see Blotters (Semi-Dry) for more info...
... QPlate is the consumable ... 16 contains 16 individually controlled ... contains a sophisticated liquid flow ... fast and precise solution and ...
This kit is designed to select cells labeled with phycoerythrin- (PE-) conjugated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
... bring you ease of use and rapid solutions to meet your laboratory's requirements for data management ... ... ... CLARA® is the standard software for Staccato Systems and ...
Biology Products: