Navigation Links
Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines
Date:1/29/2012

Genetics has provided surprising insights into why vaccines used in both the UK and US to combat serious childhood infections can eventually fail. The study, published today in Nature Genetics, which investigates how bacteria change their disguise to evade the vaccines, has implications for how future vaccines can be made more effective.

Pneumococcus (Streptococcus pneumoniae) causes potentially life-threatening diseases including pneumonia and meningitis. Pneumococcal infections are thought to kill around a million young children worldwide each year, though the success of vaccination programmes has led to a dramatic fall in the number of cases in countries such as the UK and US. These vaccines recognise the bacteria by its polysaccharide, the material found on the outside of the bacterial cell. There are over ninety different kinds or 'serotypes' of the bacteria, each with a different polysaccharide coating.

In 2000, the US introduced a pneumococcal vaccine which targeted seven of the ninety serotypes. This '7-valent' vaccine was extremely effective and had a dramatic effect on reducing disease amongst the age groups targeted. Remarkably, the vaccine has also prevented transmission from young children to adults, resulting in tens of thousands fewer cases of pneumococcal disease each year. The same vaccine was introduced in the UK in 2006 and was similarly successful.

In spite of the success of the vaccine programmes, some pneumococcal strains managed to continue to cause disease by camouflaging themselves from the vaccine. In research funded by the Wellcome Trust, scientists at the University of Oxford and at the Centers for Disease Control and Prevention in Atlanta studied what happened after the introduction of this vaccine in the US. They used the latest genomic techniques combined with epidemiology to understand how different serotypes of the pneumococcus bacteria evolve to replace those targeted by the initial v
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ambry Genetics Reports Results from Clinical Diagnostic Exome™ Testing of Three Patients
2. The power of flowers: Research sprouts a closer look at sunflower genetics
3. New international Ph.D. program on Dynamics of Gene Regulation, Epigenetics and DNA Damage Response
4. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
5. Genetics professor Jonathan Arnold named AAAS Fellow
6. YeastBook, the Eukaryotic Cell Encyclopedia is launched by Genetics
7. Fish flu: Genetics approach may lead to treatment
8. Modern genetics answers age-old question on Garrods fourth inborn error of metabolism
9. Einstein College of Medicine given $6.7 million to study congenital heart defect genetics
10. New discoveries in genetics of lung health
11. Genetics meets metabolomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... Apple introduced the fingerprint reading feature with the iPhone ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... make it easier to detect and prevent counterfeit microcircuits ... the agency started performing an in-house microcircuit anti-counterfeit initiative ... of purchased microcircuits while increasing their reliability throughout the ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is a technology ... measures the overall facial feature of a person such ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... Technology Company Limited, a,global provider of biometric software ... a high performance fingerprint access and,attendance control device ... device) and FS20 (low cost device), Futronic is ... control device.,FS22 uses a powerful Digital Signal Processor ...
... on the social and ecological sustainability of biofuels and ... Central and South America will take place on Friday, ... conference, Biofuels and Neotropical Forests: Trends, Implications and Emerging ... Initiative (ELTI) and the Program in Native Species Reforestation, ...
... exposed to hairspray in the workplace during pregnancy have more ... genital birth defect hypospadias, according to a new study published ... The study is the first to show a significant ... birth defects of the male genitalia, where the urinary opening ...
Cached Biology News:Futronic Launches FS22 Fingerprint Access Control Device 2Conference to explore sustainability of biofuels 2Hairspray is linked to common genital birth defect, says study 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
(Date:1/22/2015)... 2015  Varian Medical Systems (NYSE: VAR ), world ... its commitment to sustainability with inclusion on a prestigious list ... ranked healthcare equipment company among the Corporate Knights Global 100 ... Forum at Davos, Switzerland . ...
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer Experience ... Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and ... of revenues. , Browse 152 market data tables, ... on “Service Quality Management (SQM) and Telco Customer Experience ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... WILMINGTON, Delaware, November 3 ... Advanced Technologies Market, (2009 - 2014),published by MarketsandMarkets ... global stem cell market. It identifies and analyzes,the ... various,products, services, technologies, and applications submarkets in different,geographic ...
... has won a $4.4 million grant from the ... (ARPA-E) to lead a multidisciplinary, multi-institutional research project ... magnets. Stronger magnets are essential for increasing ... and communications systems in the 21st-century, and for ...
... The World Egg Bank (TWEB), an international ... announced a first-of-its-kind partnership with a European fertility clinic to ... of donated frozen eggs at or less than the cost ... is between TWEB and IVI in Alicante, Spain, the world,s ...
Cached Biology Technology:MarketsandMarkets: Global Stem Cell and Advanced Technologies Market Worth US$ 88.3 Billion By 2014 2MarketsandMarkets: Global Stem Cell and Advanced Technologies Market Worth US$ 88.3 Billion By 2014 3UD wins $4.4 million to develop next-generation magnets 2World Egg Bank Launches Medical Tourism Program With World's Largest Egg-Donation Fertility Clinic 2
Monkey IL-2 ELISPOT Kit with white/opague microtiter plates...
B2-Microgloulin...
...
... offers versatile liquid handling platforms and flexible ... variety of life science applications.The Freedom EVO ... (75, 100, 150 and 200 cm), giving ... that will advance with their application needs. ...
Biology Products: