Navigation Links
Genetics of melanoma chemoresistance
Date:6/5/2011

Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In this paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") that can ultimately promote metastasis and contribute to melanoma relapse.

While cellular senescence has been thought of as a natural mechanism to combat uncontrolled cell growth, or cancer, recent studies have shown that some cell types express a secretome during senescence that alters the tumor microenvironment and affects the cell's response to chemotherapeutic drugs. Ohanna et al. confirm that senescent melanoma cells do, in fact, express an inflammatory secretome, and have delineated the genetic pathways involved: Depletion of the MITF transcription factor, or exposure to anti-melanoma drugs, activates the DNA damage response and triggers senescence. Senescent melanoma cells express a PARP-1 and NF-kBassociated secretome, which contains high levels of the chemokine CCL2. CCL2, in turn, leads to a loss of E-cadherin expression and an invasive phenotype.

In fact, Ohanna et al. show that culturing melanoma cells with exogenous CCL2 enhances their survival and invasiveness. This finding suggests that blocking CCL2, or its upstream effectors, may represent a novel therapeutic pathway. As Dr. Bertolotto explains, "Our data disclose a part of the mechanisms contributory to failure of anti-melanoma chemotherapies and we gain valuable insight for the identification of new candidates, namely PARP-1, NF-kB or CCL2, for therapeutic intervention in view to overcome drug resistance."


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Population genetics reveals shared ancestries
2. MARC travel awards announced for GSA Mouse Genetics Conference
3. Michael S. Watson, Ph.D., receives Am College of Medical Genetics-ACMG Foundation Presidents Award
4. Anna-Kaisa Niemi awarded 2011 Genzyme/ American College of Medical Genetics Foundation Fellowship
5. Zimmerman receives Richard King Trainee Award for best publication in genetics in medicine
6. MARC Travel Awards announced for GSA 26th Fungal Genetics Meeting
7. New data published in Nature Genetics demonstrate that tiny LNA-based compounds developed by Santaris Pharma A/S inhibit entire disease-associated microRNA families
8. SoftGenetics to Supply Forensic Analysis Software for IntegenXs Automated DNA Identity Profiling System
9. Media alert: ACMG 2011 Clinical Genetics Meeting -- press registration is now open
10. Lifestyle affects life expectancy more than genetics
11. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... , ... April 20, 2017 , ... ... the scientific and clinical research community’s growing body of knowledge during its ... the Gracie Theatre and the adjacent Darling Atrium. During the event, undergraduates, graduate ...
(Date:4/20/2017)... MN and Bethesda, MD (PRWEB) , ... April ... ... Advancing Innovation announce the formation of a unique intellectual property (IP) sharing and ... potential of their most promising inventions. A main component of this effort is ...
(Date:4/19/2017)... ... ... A number of new instruments have recently emerged to accommodate different applications ... and Cell Analysis Education Webinar Series , will focus on advances in the Invitrogen™ ... applications. , Many flow cytometers have unique capabilities and the Attune NxT Flow ...
(Date:4/19/2017)... ... April 19, 2017 , ... WHO: Peggy Lillis Foundation, the ... and advocacy. Founded in 2010 in memory of a single-parent mom and kindergarten ... become the most-consulted source for patient-focused information on C. diff infections in the ...
Breaking Biology Technology: