Navigation Links
Genetics of melanoma chemoresistance
Date:6/5/2011

Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In this paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") that can ultimately promote metastasis and contribute to melanoma relapse.

While cellular senescence has been thought of as a natural mechanism to combat uncontrolled cell growth, or cancer, recent studies have shown that some cell types express a secretome during senescence that alters the tumor microenvironment and affects the cell's response to chemotherapeutic drugs. Ohanna et al. confirm that senescent melanoma cells do, in fact, express an inflammatory secretome, and have delineated the genetic pathways involved: Depletion of the MITF transcription factor, or exposure to anti-melanoma drugs, activates the DNA damage response and triggers senescence. Senescent melanoma cells express a PARP-1 and NF-kBassociated secretome, which contains high levels of the chemokine CCL2. CCL2, in turn, leads to a loss of E-cadherin expression and an invasive phenotype.

In fact, Ohanna et al. show that culturing melanoma cells with exogenous CCL2 enhances their survival and invasiveness. This finding suggests that blocking CCL2, or its upstream effectors, may represent a novel therapeutic pathway. As Dr. Bertolotto explains, "Our data disclose a part of the mechanisms contributory to failure of anti-melanoma chemotherapies and we gain valuable insight for the identification of new candidates, namely PARP-1, NF-kB or CCL2, for therapeutic intervention in view to overcome drug resistance."


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Population genetics reveals shared ancestries
2. MARC travel awards announced for GSA Mouse Genetics Conference
3. Michael S. Watson, Ph.D., receives Am College of Medical Genetics-ACMG Foundation Presidents Award
4. Anna-Kaisa Niemi awarded 2011 Genzyme/ American College of Medical Genetics Foundation Fellowship
5. Zimmerman receives Richard King Trainee Award for best publication in genetics in medicine
6. MARC Travel Awards announced for GSA 26th Fungal Genetics Meeting
7. New data published in Nature Genetics demonstrate that tiny LNA-based compounds developed by Santaris Pharma A/S inhibit entire disease-associated microRNA families
8. SoftGenetics to Supply Forensic Analysis Software for IntegenXs Automated DNA Identity Profiling System
9. Media alert: ACMG 2011 Clinical Genetics Meeting -- press registration is now open
10. Lifestyle affects life expectancy more than genetics
11. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... a rare, but deadly disease that exists as five ... the most lethal strains is the Sudan ebolavirus (SUDV). ... has caused widespread illness, even as recently as 2012. ... ACS Chemical Biology , researchers now report a possible ... SUDV. , John Dye, Sachdev Sidhu, Jonathan Lai and ...
(Date:8/27/2014)... Thousands of fishing traps are lost or abandoned each ... as derelict traps, which continue to catch fish, crabs, ... in losses to habitat, fisheries, and the watermen who ... to a newly published NOAA study. , The report, ... the first of its kind to examine the derelict ...
(Date:8/27/2014)... can be weaned later with no negative effects on ... at the University,s Roseworthy campus, published in the journal ... for pig producers. It allows improvements in piglet health ... usually start their oestrous cycles again during lactation, only ... says Ms Alice Weaver, PhD candidate with the School ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2Piglet weaning age no bar to litter frequency 2
... This release is available in French . ... memories is essential to our daily existence and identity; enabling ... researchers at the Montreal Neurological Institute and Hospital (The Neuro), ... an image for the first time of a mechanism, specifically ...
... The mystery of giant sperm present in some living ... In one group of micro-crustaceans new evidence shows the ... Renate Matzke-Karasz, from Ludwig-Maximilians-Universitt Munich (Germany), has ... the London Natural History Museum,s collections. Their research has ...
... Scavia and his colleagues say this year,s Gulf of Mexico ... continuing a decades-long trend that threatens the health of a ... for a Gulf dead zone of between 7,450 and 8,456 ... Most likely, this summer,s Gulf dead zone will blanket about ...
Cached Biology News:Scientists capture the first image of memories being made 2Size did matter 2U-M researcher and colleagues predict large 2009 Gulf of Mexico 'dead zone' 2U-M researcher and colleagues predict large 2009 Gulf of Mexico 'dead zone' 3
(Date:8/28/2014)... executives from clinical trial marketing firm BBK Worldwide will lead ... Clinical Trials 2014 , to be held at the Hyatt ... Patient recruitment experts Bonnie A. Brescia , Matthew ... on the benefits of employing an effective patient engagement strategy, ... mobile apps – can be used to drive study participation ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 PrimeSource ... construction materials, selected SoundConnect to support ... cloud based audio and web conferencing platform GlobalMeet ... support PrimeSource’s employees’ needs. SoundConnect delivers award ... , PrimeSource Building Products will be utilizing ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has raised ... secured Otter Capital as a significant new partner. Otter ... GGI’s Agriplier™ technology, building on recent compelling field trial ... first meeting, we have been impressed with Otter Capital’s ... Alan Sobba, President and CEO of GGI. “We look ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... PARIS, September 11 Novexel, a specialty pharmaceutical,company ... antibiotics,designed to overcome the significant global problem of ... subject of 16 posters and one slide,presentation at ... on,Antimicrobial Agents and Chemotherapy (ICAAC). The ICAAC meeting, ...
... , SUNRISE, Fla., Sept. 10 Bioheart, Inc., ... devices and biologics that help monitor, diagnose and treat heart ... Vice President of R&D and Corporate development has been invited ... Baltimore, Maryland, this month. , , Ms. ...
... , HOUSTON, Sept. 10 ... with Beech Street Corporation, one of the nation,s largest preferred ... assist SpectraCell with the ever-increasing administrative needs that accompany healthcare ... , Beech Street addresses the various coverage obstacles ...
Cached Biology Technology:Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 2Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 3Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 4Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 5Bioheart Inc. to Participate in the 2009 World Stem Cell Summit on September 23rd 2Bioheart Inc. to Participate in the 2009 World Stem Cell Summit on September 23rd 3SpectraCell Contracts With Beech Street Corporation 2