Navigation Links
Genetics meets metabolomics
Date:9/1/2011

Scientists at Helmholtz Zentrum Munich and LMU Munich, in cooperation with Wellcome Trust Sanger Institute and King's College London (KCL), have identified several associations between genetic variants and specific metabolic changes. The study, published today in Nature, provides new functional insights regarding associations between risk factors and the development of complex common diseases.

In the study appearing today in the journal Nature, the researchers identified 37 previously unknown genetic risk loci, elucidated their effect on human metabolism and found clear associations to complex common diseases such as type 2 diabetes mellitus. Professor Karsten Suhre and Dr. Christian Gieger of Helmholtz Zentrum Mnchen, together with colleagues from the Wellcome Trust Sanger Institute in the UK and King's College London under the leadership of Nicole Soranzo, conducted this research to gain in-depth insight into the etiology of disease. In the study, the scientists present the most comprehensive evaluation of genetic variance in human metabolism so far, combining genome-wide association studies * (GWAS) with metabolomics*. Over 250 metabolites were analyzed from 60 disease-relevant metabolic pathways.

"The advantage of our study design," Suhre and Gieger said, "is that we studied genetic variance in its biological context and thus identified previously unknown risk loci." By combining genetics and metabolomics, a method which already yielded promising results in two previous studies, the scientists were able to evaluate the biological effect of the identified genetic risk loci. In stand-alone GWAS this is not possible.

Every individual is unique a closer look at the individual's metabolites could enable a better evaluation of the risks for developing complex common diseases in the future. "We have made considerable advances in understanding complex diseases such as type 2 diabetes mellitus," the two scientists said. "The fin
'/>"/>

Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Modern genetics vs. ancient frog-killing fungus
4. New research helps explain genetics of Parkinsons disease
5. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
6. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
7. Study examining role of genetics and environment in type 1 diabetes
8. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
9. Roberta A. Pagon receives lifetime award in genetics from March of Dimes
10. Margarita Saenz, M.D. is recipient of Genzyme/ACMGF Fellowship in Biochemical Genetics
11. Bad mix of bacterial remnants and genetics leads to arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ... expand its team and bring LaunchKey to market in ...
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... Technology and Society Forum presentation on March 23, 2011 ... University Professor Sheena Iyengar, will address the psychological and ... her discipline-spanning research. Her talk, "The ... choice and freedom, and why one doesn,t always complement ...
... WASHINGTON, D.C. (March 8, 2011) -- Researchers at the ... of Texas at Dallas are reporting today at the ... how they are using a novel 3D cell imaging ... transport, providing a solution to this fundamental problem in ...
... blood cell production and function will today be awarded ... Council,s (NHMRC) program grants scheme. The nine ... securing $107 million in program grant funding will be ... the Federal Minister for Mental Health and Ageing, the ...
Cached Biology News:Columbia professor to discuss good, bad aspects of choice at NJIT March 23 talk 2$38.4M NHMRC program grants extend cancer and blood cell research 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this ... James L. Sherley, director of the Adult Stem Cell ... an often overlooked and under appreciated unique property of ... by Distributed Stem Cells: Misunderstood in the Past, Important ... to congress participants. He gave the address at ...
(Date:12/24/2014)... 23, 2014 According to Ross Selinger, President ... of ITRA Global, the national office market continues to be ... This is evidenced by the third quarter’s surprising 3.9% GDP, ... Low energy costs have held inflation down and the Fed ... the housing market remaining soft. , This solid economic news ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... , MORRISVILLE, N.C. , April 23 Asymchem Laboratories ... as Director of Formulation Development, Dr. Pingzhong Huang as Director of Chemical ... Development. , , , ... (George) Xu joined Asymchem on February 1, 2010 .  He ...
... ... Awards Program recognizes these organizations for their outstanding innovations and excellence in the use ... research, and clinical trials. , ... Needham, Mass. (PRWEB) April 23, 2010 -- Bio-IT World magazine announced ...
... ... ISSSEEM conference will be of interest only to those who are going to ... live a life of happiness and value.” The International Society for ... annual conference, Evidence-based Spirituality for the 21st Century, June 25-29, 2010 at the ...
Cached Biology Technology:Asymchem Laboratories Hires Three New Employees: Guojie Xu, Pingzhong Huang, and Xiaojun Huang 2BIO-IT World Announces the Winners of its 2010 Best Practices Awards Program 2BIO-IT World Announces the Winners of its 2010 Best Practices Awards Program 3BIO-IT World Announces the Winners of its 2010 Best Practices Awards Program 4BIO-IT World Announces the Winners of its 2010 Best Practices Awards Program 5BIO-IT World Announces the Winners of its 2010 Best Practices Awards Program 620th Annual ISSSEEM Conference – Evidence-based Spirituality for the 21st Century 220th Annual ISSSEEM Conference – Evidence-based Spirituality for the 21st Century 3
...
Experion spin filters are used to filter the gel matrix and gel stain solution prior to use with the Experion automated electrophoresis system. Supplied as 10 spin filters....
... use in the Microsart e.motion are sterile-sealed, without ... a specially designed individual package on a band. ... of membrane filter units ensures that they are ... sealed band guarantees uniform dispensing of the individual ...
... The model 55S Rocking Shaker provides ... and blotted membranes. The very slow ... degree of tilt provide a gentle ... over gels and blotted membranes to ...
Biology Products: