Navigation Links
Genetics meets metabolomics
Date:9/1/2011

Scientists at Helmholtz Zentrum Munich and LMU Munich, in cooperation with Wellcome Trust Sanger Institute and King's College London (KCL), have identified several associations between genetic variants and specific metabolic changes. The study, published today in Nature, provides new functional insights regarding associations between risk factors and the development of complex common diseases.

In the study appearing today in the journal Nature, the researchers identified 37 previously unknown genetic risk loci, elucidated their effect on human metabolism and found clear associations to complex common diseases such as type 2 diabetes mellitus. Professor Karsten Suhre and Dr. Christian Gieger of Helmholtz Zentrum Mnchen, together with colleagues from the Wellcome Trust Sanger Institute in the UK and King's College London under the leadership of Nicole Soranzo, conducted this research to gain in-depth insight into the etiology of disease. In the study, the scientists present the most comprehensive evaluation of genetic variance in human metabolism so far, combining genome-wide association studies * (GWAS) with metabolomics*. Over 250 metabolites were analyzed from 60 disease-relevant metabolic pathways.

"The advantage of our study design," Suhre and Gieger said, "is that we studied genetic variance in its biological context and thus identified previously unknown risk loci." By combining genetics and metabolomics, a method which already yielded promising results in two previous studies, the scientists were able to evaluate the biological effect of the identified genetic risk loci. In stand-alone GWAS this is not possible.

Every individual is unique a closer look at the individual's metabolites could enable a better evaluation of the risks for developing complex common diseases in the future. "We have made considerable advances in understanding complex diseases such as type 2 diabetes mellitus," the two scientists said. "The findings of the study will lead to new approaches for pharmaceutical research."


'/>"/>

Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Modern genetics vs. ancient frog-killing fungus
4. New research helps explain genetics of Parkinsons disease
5. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
6. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
7. Study examining role of genetics and environment in type 1 diabetes
8. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
9. Roberta A. Pagon receives lifetime award in genetics from March of Dimes
10. Margarita Saenz, M.D. is recipient of Genzyme/ACMGF Fellowship in Biochemical Genetics
11. Bad mix of bacterial remnants and genetics leads to arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... report to their offering. ... The global voice recognition biometrics market to grow ... The report covers the present scenario and the growth prospects ... the market size, the report considers the revenue generated from the ...
(Date:1/19/2017)... 2017 Sensory Inc ., a ... for consumer electronics, and i nnerCore ... cybersecurity solutions, today announced a global partnership that ... worldwide to bolster security of data sensitive mobile ... authentication platforms they offer, innerCore now offers its ...
(Date:1/18/2017)... MINNETONKA, Minn. , Jan. 18, 2017 /PRNewswire/ ... eClinical technology company that supports the entire spectrum ... 2016 has been another record-breaking year for the ... and market interest in MedNet,s eClinical products and ... to the tremendous marketplace success of ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 23, 2017 , ... The Foundation ... unique partnerships, seeks outstanding early career nominees for the 2017 New Innovator in ... the needs of a world in which one in nine people suffers from ...
(Date:1/24/2017)... Fla. , Jan. 23, 2017  Recognizing ... focused on scientific discovery and solutions, the University ... the Frost Institutes for Science and Engineering to ... and mathematics (STEM) to help solve some of ... of Miami President Julio Frenk unveiled ...
(Date:1/24/2017)... 23, 2017  Today, the Fisher Center for Alzheimer,s ... an important study that could lead to the development ... Alzheimer,s disease. This groundbreaking research was conducted by the ... Nobel Laureate Dr. Paul Greengard , in the ... Fisher Center scientists have linked a mutation that ...
(Date:1/23/2017)... 23, 2017  Spherix Incorporated (Nasdaq: SPEX ... fostering of technology and monetization of intellectual property, today ... Anthony Hayes , Chief Executive Officer ... continue to communicate with shareholders about the status of ... diligence on other patent assets that fit with our ...
Breaking Biology Technology: