Navigation Links
Genetics meets metabolomics
Date:9/1/2011

Scientists at Helmholtz Zentrum Munich and LMU Munich, in cooperation with Wellcome Trust Sanger Institute and King's College London (KCL), have identified several associations between genetic variants and specific metabolic changes. The study, published today in Nature, provides new functional insights regarding associations between risk factors and the development of complex common diseases.

In the study appearing today in the journal Nature, the researchers identified 37 previously unknown genetic risk loci, elucidated their effect on human metabolism and found clear associations to complex common diseases such as type 2 diabetes mellitus. Professor Karsten Suhre and Dr. Christian Gieger of Helmholtz Zentrum Mnchen, together with colleagues from the Wellcome Trust Sanger Institute in the UK and King's College London under the leadership of Nicole Soranzo, conducted this research to gain in-depth insight into the etiology of disease. In the study, the scientists present the most comprehensive evaluation of genetic variance in human metabolism so far, combining genome-wide association studies * (GWAS) with metabolomics*. Over 250 metabolites were analyzed from 60 disease-relevant metabolic pathways.

"The advantage of our study design," Suhre and Gieger said, "is that we studied genetic variance in its biological context and thus identified previously unknown risk loci." By combining genetics and metabolomics, a method which already yielded promising results in two previous studies, the scientists were able to evaluate the biological effect of the identified genetic risk loci. In stand-alone GWAS this is not possible.

Every individual is unique a closer look at the individual's metabolites could enable a better evaluation of the risks for developing complex common diseases in the future. "We have made considerable advances in understanding complex diseases such as type 2 diabetes mellitus," the two scientists said. "The fin
'/>"/>

Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Modern genetics vs. ancient frog-killing fungus
4. New research helps explain genetics of Parkinsons disease
5. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
6. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
7. Study examining role of genetics and environment in type 1 diabetes
8. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
9. Roberta A. Pagon receives lifetime award in genetics from March of Dimes
10. Margarita Saenz, M.D. is recipient of Genzyme/ACMGF Fellowship in Biochemical Genetics
11. Bad mix of bacterial remnants and genetics leads to arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... that let nerve cells send out electrical signals, Johns ... tactic that may offer a new way to protect ... responsible way. , Their findingthat naturally occurring insect ... for a closely related onesuggests that insecticides can be ... like bees. A summary of the research, led by ...
(Date:7/10/2014)... COLORADO SPRINGS, Colo. , June 27, 2014 ... announces that the National Institute of Standards and ... appointed 10 of its academic research and forensic ... Board (FSSB).  The Board is an element of ... These AAFS members are among the first appointments ...
(Date:7/10/2014)... SPRINGS, Florida , July 1, 2014 ... wallets pave way for convenience and improved security: NXT-ID, Inc. ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) ... is pleased to announce that the second series of 30 ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... you like to experience the effects of running three miles ... in your lifestyle? With nutrition supplements developed by a professor ... NuSirt Sciences Inc., founded by Professor Emeritus of nutrition Michael ... a product for healthy blood sugar called NuControl. ...
... Naples have shown that minimal modification of a synthetic peptide ... than two orders of magnitude higher binding affinity to the ... be a step toward the design of new, more effective ... Different strains of HIV-1 use either the chemokine ...
... 9, 2012 -- Through novel experiments involving small nematode ... may be potential targets for drug development in the ... these genes could reverse certain key traits associated with ... 2012 issue of the Genetics Society of America,s journal ...
Cached Biology News:University of Tennessee professor releases weight management product 2Potential drug molecule shows enhanced anti-HIV activity 2Scientists use worms to unearth cancer drug targets 2
(Date:7/10/2014)... July 10, 2014 OMICS Group’s 5th ... during 18-20 August, 2014 at Double Tree by Hilton ... recent developments in Analytical & Bioanalytical research methods only ... Speaking on this occasion, Dr. Srinubabu Gedela, MD of ... conference is a remarkable one in bringing a unique ...
(Date:7/10/2014)... Ind. , July 10, 2014 /PRNewswire/ ... its use of capnography for respiratory monitoring ... group of healthcare leaders in embracing state-of-the-art ... how effectively patients are breathing and can ... occurs. By measuring the amount of carbon ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... According to the International Atomic Energy Agency (IAEA) ... terrorists acquiring sufficient quantities of plutonium or highly ... explosive device. The IAEA also notes that most ... quantities, which can be challenging to detect with ... study appearing this week in the Journal ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2
... ... ... var shortURL ... we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
... Dyadic International, Inc. (Pink Sheets: DYAI ), ... release financial results for the third quarter ended September ... open to be followed by a conference call at ... (Logo: http://www.newscom.com/cgi-bin/prnh/20091214/DYADICLOGO) The conference call may ...
... Verenium Corporation (Nasdaq: VRNM ), a ... enzyme solutions, today announced that Janet Roemer, President and ... 10th Global Clean Technology Conference.  The presentation is scheduled ... 16, 2010 and will take place in London. ...
Cached Biology Technology:Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 2Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 3Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 4Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 5Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 6Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 7Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 8Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 9Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 10Aeterna Zentaris Reports Third Quarter 2010 Financial and Operating Results 11Verenium to Present at Jefferies 10th Global Clean Technology Conference 2Verenium to Present at Jefferies 10th Global Clean Technology Conference 3
Applications: Epitope mapping, Mapping protein-protein contacts, Identification of enzyme substrates/inhibitors, Identification of receptor agonists/antagonists...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
QML offers standard and customized paraffin embedded tissue blocks....
Biology Products: