Navigation Links
Genetics determine optimal drug dose of common anticoagulant
Date:8/21/2007

(WASHINGTON, August 21, 2007) Genetic testing can be used to help personalize the therapeutic dosage of warfarin, a commonly-used anticoagulant, according to research published in the September 1, 2007, issue of Blood, the journal of the American Society of Hematology. This result represents one of the first applications of using an individuals genetic information to guide personal medical care.

Because individuals metabolize drugs differently, varying doses of warfarin are needed for the drug to be effective in each patient. Too much warfarin can cause severe bleeding, and too little can cause dangerous blood clots. Currently, there is little guidance for predicting how much of the drug a person will need. Physicians have had to roughly estimate an initial dose of warfarin and then continually monitor a patients International Normalized Ratio (INR) value (a measure of how fast the blood clots), during treatment to tweak the dosage by trial and error.

For the first time, a group of St. Louis researchers combined the standard INR method with genetic testing to predict the therapeutic warfarin dose. Since warfarin is often prescribed after major orthopedic surgery to prevent blood clots in the legs, the study followed 92 adults undergoing either total hip or knee replacement at the Washington University Medical Center, who had never previously taken the anticoagulant.

Prior to warfarin treatment, the researchers collected blood samples and each patients medical history. The blood tests were used to examine variations in two genes, CYP2C9 and VKORC1, that may affect warfarin dosing. Variants in CYP2C9 impair the bodys breakdown of warfarin; variants in VKORC1 cause increased warfarin sensitivity. The patients were assigned initial doses of warfarin based on clinical factors and their genotype. The researchers followed the patients until successful treatment outcomes were achieved several weeks later.

By combining varia
'/>"/>

Contact: Laura Stark
lstark@hematology.org
202-552-4914
American Society of Hematology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
2. Genetics links whale to two different ocean basins
3. New technique could alter field of mouse genetics
4. Scientists unpick genetics of first 15 minutes of life
5. New research examines genetics of successful aging
6. Alcoholism, smoking and genetics among Plains American Indians
7. New research examines genetics of successful aging
8. Newly-discovered class of genes determines ?and restricts ?stem cell fate
9. Biologists determine genetic blueprint of social amoeba
10. International Team Determines Geographic Origin of Leprosy
11. USC researchers determine mechanism of action of chemotherapy drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... China , 31 de julio de 2015 ... www.icg-10.org ) se celebrará por medio de BGI del 22 al ... . Este año, la conferencia celebra ... ICG se ha convertido en una de las reuniones anuales ... ser una de las reuniones más dinámicas, entusiastas y mejores ...
(Date:7/31/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... 62/198989 for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT METHOD AND ... advance crypto-currencies such as Bitcoin into the consumer market ... to manage all payments.  The technology ...
(Date:7/30/2015)... , July 30, 2015 Cellecta, ... for gene function analysis and biomarker discovery, announced ... (sgRNA) Knockout Library targeting all human protein coding ... permanently "knock out" a gene,s function. Cellecta,s new ... high throughput screening tool so that researchers can ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... In April 2010, the US government adopted a new nuclear ... defense systems will reliably protect the continental United States in ... Bulletin of Atomic Scientists , published by SAGE, shows ... and would not be effective in real combat conditions. ...
... the human immune system,s assassin a protein called perforin ... funded by the Biotechnology and Biological Sciences Research Council (BBSRC) ... where they used powerful electron microscopes to study the mechanism ... research is published today (1800hrs, 31 October) in Nature ...
... have discovered a new member of a gene family that ... weight. The gene is the third member of the agouti ... One helps determine skin and hair color, and the other ... new gene, called agrp2, has been found exclusively in bony ...
Cached Biology News:US nuclear safety claim is a 'dangerous fantasy' 2US nuclear safety claim is a 'dangerous fantasy' 3Immune system assassin's tricks visualised for the first time 2Newly discovered gene enables fish to 'disappear' 2
(Date:8/3/2015)... At the 11th hour, London,s ... of Jude Liversage,s campaign so the seven-year-old ...      (Photo: http://photos.prnewswire.com/prnh/20150803/254228 ) ... The Selective Dorsal Rhizotomy (SDR) procedure reduced the spasticity ... wish to kick a ball around like his schoolmates. ...
(Date:8/3/2015)... ... ... Nine field days to promote practices that improve soil health will take place ... , the field days will demonstrate how changing certain practices, such as adding cover ... Brent Bible has practiced no-till farming and planted cover crops on his farm in ...
(Date:8/3/2015)... According to a new market ... Asia to Witness Highest Growth ... cell culture market was valued at US$ 586.1 Mn in ... of 29.1% to account for US$ 2,717.6 Mn by ... 3D cell culture refers to a ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... analysis and premium industry insights on the global resorcinol industry. The report highlights ... study of vivid market scenarios and analysis of primary and secondary inputs from ...
Breaking Biology Technology:Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4
... 2011) After Fukushima, it is now imperative to redefine ... to grave. If nuclear waste management is not thought out ... nuclear power as an energy choice, according to research that ... , published by SAGE. According to Allison Macfarlane, associate ...
... just fifteen minutes to analyze a sample suspected of ... The technology amplifies any anthrax DNA present in the ... microscopic cells of the deadly bacteria Bacillus anthracis. ... lethal microbe that might be used intentionally to infect ...
... significant threat to humans, as emphasized by the recent effects ... on July 21st by the Cell Press journal Developmental ... similar and divergent strategies that different toxins use to invade ... protein derived from the castor bean plant that has raised ...
Cached Biology Technology:Nuclear waste requires cradle-to-grave strategy 2Nuclear waste requires cradle-to-grave strategy 3Nano detector for deadly anthrax 2Targeting toxin trafficking 2
Rat polyclonal to acetyl Salicylic Acid ( Abpromise for all tested applications)....
Mouse monoclonal [DJR3] to DcR1 (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 8794 SwissProtID: O14798...
GBL Antibody...
Human acetylcholine receptor (AChR)-alpha. Exhibits homogenous, high affinity,binding to the receptor. Binds weakly to a64-78. Inhibits binding of many,myasthenia gravis sera to human AChR....
Biology Products: