Navigation Links
Genetics Society of America's Genetics journal highlights for March 2013
Date:3/5/2013

Genetics:
A novel interaction between aging and ER overload in a protein conformational dementia, pp. 865-876
Angela Schipanski, Sascha Lange, Alexandra Segref, Aljona Gutschmidt, David A. Lomas, Elena Miranda, Michaela Schweizer, Thorsten Hoppe, and Markus Glatzel

This article describes a novel interaction between aging and ER overload. The authors studied a dementia disease in Caenorhabdidis elegans and mice to learn how disturbed protein homeostasis contributes to disease development. They show that induction of the unfolded protein response is critical for age-related disease progression. Their results suggest that the unfolded protein response may offer a therapeutic target for dementias.

Genome Integrity and Transmission:
Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast, pp. 751-770
Lindsey N. Williams, Alan J. Herr, and Bradley D. Preston

Mutators accelerate microbial adaptation (and mammalian oncogenesis), but the fitness cost of increased mutation imposes pressure to reduce mutation rates. In this investigation of pathways of mutator suppression, the authors show that yeast cells defective in mismatch repair and in proofreading by the primary leading-strand DNA polymerase are inviable, but escape this error-induced extinction by acquiring antimutator alleles. These findings illustrate the inherent instability of mutators and reveal multiple mechanisms of their suppression.


'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Geneticist Svante Pääbo receives the $500,000 Gruber Genetics Prize
2. Life experiences put their stamp on the next generation: New insights from epigenetics
3. Epigenetics shapes fate of brain vs. brawn castes in carpenter ants
4. How plants sense gravity -- a new look at the roles of genetics and the cytoskeleton
5. Aztec conquest altered genetics among early Mexico inhabitants, new DNA study shows
6. Genetics plays major role in victimization in elementary school
7. ACMG 2013 Clinical Genetics Meeting -- Complimentary press registration is now open
8. Genetics Society of America announces Spring 2013 DeLill Nasser Travel Award recipients
9. GW professor discovers new information in the understanding of autism and genetics
10. Prickly holly reveals ability to adapt genetics to environmental change
11. Study finds epigenetics, not genetics, underlies homosexuality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... 18, 2013 The herbal extract of a yellow-flowered ... to increase the lifespan of fruit fly populations by ... researchers. , But it,s how Rhodiola ... that grabbed the attention of study leaders Mahtab Jafari ... works in a manner completely unrelated to dietary restriction ...
(Date:6/18/2013)... chemical modification of DNA and this modification can ... sequence. Until now, scientists believed that this epigenetic ... Today, a team of researchers from the University ... Louis-Jeantet Professor at the Faculty of Medicine, reveals ... that DNA methylation may play both a passive ...
(Date:6/18/2013)... that weight gain and increased head size in the first month ... early school age. , The study was led by University of ... children who were born full-term. , The results, published in the ... on 40% of their birthweight in the first four weeks had ... years of age, compared with babies who only put on 15% ...
Breaking Biology News(10 mins):Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2The secret of DNA methylation 2IQ link to baby's weight gain in first month 2
... at the University of California, San Francisco, have identified a ... parrots and exotic birds for more than 30 years. ... and Don Ganem, MD, also has developed a diagnostic test ... which will enable veterinarians worldwide to control the spread of ...
... treatments may sharpen mental performance in women with ... suggest that recharging a naturally occurring estrogen receptor ... The discovery suggests that drugs can be ... estrogen levels, as well as to protect against ...
... dioxide from the atmosphere, and from the human use of ... for the Earth,s life support system. The chemical balance of ... know that the pH of the sea,s surface water has ... beginning of industrialisation just over a century ago. Jon Havenhand ...
Cached Biology News:UCSF researchers identify virus behind mysterious parrot disease 2Improved estrogen reception may sharpen fuzzy memory 2Improved estrogen reception may sharpen fuzzy memory 3Acidification of the sea hampers reproduction of marine species 2
(Date:6/18/2013)... 2013 As a leading provider ... announces the release of their infographic - " ... , MeMD's goal was to leverage an information ... 2.0, Health 3.0 and mHealth.The infographic features a ... care and the fitness industry in unimaginable ways; ...
(Date:6/18/2013)... Minneapolis, MN (PRWEB) June 18, 2013 ... the Saniclave 200 prevent the dangers of ... confusing features, like knobs, analog pressure gauges, hot surfaces ... older autoclave, or a new, modern autoclave, Revolutionary Science ... use fresh water. Older autoclave designs will recycle ...
(Date:6/18/2013)... DC (PRWEB) June 18, 2013 On ... Services (CMS) released a final decision memorandum concluding ... to guide subsequent management of anti-tumor strategy, and ... collection. The National Oncological PET Registry (NOPR) was developed ... the first projects under the Coverage with Evidence Development ...
(Date:6/17/2013)... , June 17, 2013  KaloBios Pharmaceuticals, Inc. (Nasdaq: ... Donald R. Joseph as Chief Legal Officer.  ... biopharmaceutical industry experience and has worked in both public ... non-profit organizations. (Logo: http://photos.prnewswire.com/prnh/20130225/MM66380LOGO ) ... record as a general counsel and senior executive and ...
Breaking Biology Technology:MeMD, Inc Releases Infographic Featuring the Top Eight Technologies that are Revolutionizing Health and Fitness Today 2How to Autoclave: Why the User Friendliness of the Saniclave 200 is So Important Today 2WMIS Welcomes CMS Decision: Expanding Coverage for FDG-PET and Ending NOPR Data 2WMIS Welcomes CMS Decision: Expanding Coverage for FDG-PET and Ending NOPR Data 3KaloBios Appoints Donald R. Joseph as Chief Legal Officer 2KaloBios Appoints Donald R. Joseph as Chief Legal Officer 3KaloBios Appoints Donald R. Joseph as Chief Legal Officer 4
... 2012 All Global , the ... of patient access offers, building off developments in technology ... traditional research methods in providing greater access to patient ... these new offers comes in the area of diabetes, ...
... March 22, 2012 , Prophecy,s pre-hire ... Elsevier Performance Manager   ... more than 1,300 healthcare organizations, today announced its collaboration ... nurse assessment and competency evaluation.  Elsevier will distribute Prophecy,s ...
... BELGRADE, Mont., March 22, 2012 Bacterin International Holdings, Inc. ... development of revolutionary bone graft material and antimicrobial coatings for ... quarter and full year ended December 31, 2011: ... 72% to $9.1 million, compared to the $5.3 million for ...
Cached Biology Technology:All Global Partners With HealthEngage to Provide Unique Web 2.0 Patient Insights 2Elsevier Collaborates With Prophecy Healthcare to Enhance Its Staff Development Offerings for Healthcare Organizations 2Elsevier Collaborates With Prophecy Healthcare to Enhance Its Staff Development Offerings for Healthcare Organizations 3Elsevier Collaborates With Prophecy Healthcare to Enhance Its Staff Development Offerings for Healthcare Organizations 4Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 2Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 3Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 4Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 5Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 6Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 7Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 8Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 9Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 10
Human peripheral blood CD56+ NK cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
...
...
Biology Products: